Developing a tool for disability accommodation complexity: A sequential mixed study.

BACKGROUND: For disability accommodation (DA) decision-making/planning processes to unfold successfully, an understanding of the factors influencing DA complexity and a reliable tool for measuring such complexity are needed. The current literature does not provide sufficient knowledge on either topic. OBJECTIVE: We attempted to explore the factors influencing DA complexity and develop a DA complexity scale in three phases through the sequential mixed approach. METHOD: The study used an exploratory sequential mixed method in three phases. In phase 1, a qualitative survey of 335 supervisors with recent DA management experience was conducted, and the data were analyzed using a thematic approach to identify and evaluate DA complexity factors. In phase 2, qualitative results were transformed into items to construct a DA complexity scale. Later, the scale was tested using data from a separate quantitative cross-sectional survey of 303 supervisors with recent DA management experience. In phase 3, another quantitative cross-sectional study of 307 supervisors with recent DA management experience to evaluate the validity of the scale and its dimensions. RESULTS: In Phase 1, we identified 12 factors influencing DA complexity. In Phase 2, the DA complexity scale loaded 29 items in nine dimensions, which represented the factors influencing DA complexity. In Phase 3, DA complexity positively influenced supervisors' job demand and stress, and negatively influenced their work motivation, organizational commitment, and supervisors' perceptions about their relationships with employees with disabilities. CONCLUSION: This study enriches the DA literature by offering an in-depth understanding of DA complexity and a scale to measure it.

Assessment of the antioxidant, thrombolytic, analgesic, anti-inflammatory, antidepressant and anxiolytic activities of leaf extracts and fractions of Tetracera sarmentosa (L.) Vahl.

BACKGROUND: The plant under investigation (Tetracera sarmentosa) is a dicotyledonous flowering plant and belongs to the family Dilleniaceae. The goal of our investigation was to determine whether the leaf extracts of this plant held any significant medicinal properties. METHODS: Leaves of T. sarmentosa were extracted with pure ethanol (EETS) and methanol (METS), and then methanol extract fractioned with n-hexane (NHFMETS) and chloroform (CHFMETS). The extracts and fractions were tested for antioxidant activity, which was measured by using qualitative and quantitative procedures. Thrombolytic activity was evaluated by the clot lysis test. Analgesic activity was evaluated employing the acidic acid-induced writhing test, the formalin-induced paw licking test and tail immersion on Swiss albino mice. The anti-inflammatory activity test was studied using the paw edema test. Forced swimming, tail suspension, elevated plus maze and hole board model tests were used to evaluate neuropharmacological activity. RESULTS: All the extracts and fractions possessed antioxidant effects. All the extracts, fractions and streptokinase exhibited significant (p<0.0001) clot lysis. The extracts and fractions produced significant analgesic effects as evaluated by the acetic acid writhing test, the formalin-induced paw licking test and the tail immersion method. Similarly, carrageenan-induced inflammation was significantly antagonized by the treatments. The extracts and fractions also significantly showed neuropharmacological (antidepressant and anxiolytic) effects. CONCLUSIONS: The overall results suggested that this plant deserves further investigation to isolate the active compounds which are responsible for these activities and to establish the mechanism of action.