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1.
J Endocrinol Invest ; 30(3): 247-52, 2007 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-17505160

RESUMO

We report a case of pulmonary multinodular mucormycosis in a Type 1 diabetic patient with diabetic ketoacidosis. He had a history of 20-pack-year tobacco use. The initial chest roentgenogram and thorax tomography (after the treatment of diabetic ketoacidosis) revealed multiple nodular lesions with cavitation in the upper lobes of pulmonary parenchyma. Resection of three nodular lesion demonstrated cheesy necrotic mass in the cavitating lesions. The diagnosis of pulmonary multinodular mucormycosis was made depending on the histopathologic examination yielding nonseptated right angle branching-shaped hyphae typical of mucormycosis. The patient was started on liposomal amphotericin B and discharged at the sixth week of therapy with a scheduled therapy of amphotericin B. When he came back after 33 months, he was metabolically unregulated under the insulin therapy. He confessed that he had been smoking heroin besides tobacco for the last 5 years. A new thorax computerized tomography showed that pulmonary nodules were slightly regressed but not resolved.


Assuntos
Diabetes Mellitus Tipo 1/diagnóstico por imagem , Cetoacidose Diabética/diagnóstico por imagem , Mucormicose/diagnóstico por imagem , Infecções Respiratórias/diagnóstico por imagem , Adulto , Antifúngicos/uso terapêutico , Diabetes Mellitus Tipo 1/complicações , Diabetes Mellitus Tipo 1/tratamento farmacológico , Cetoacidose Diabética/complicações , Cetoacidose Diabética/tratamento farmacológico , Dependência de Heroína/complicações , Dependência de Heroína/diagnóstico por imagem , Humanos , Masculino , Mucormicose/complicações , Mucormicose/tratamento farmacológico , Radiografia , Infecções Respiratórias/complicações , Infecções Respiratórias/tratamento farmacológico
2.
Eur Respir J ; 26(5): 875-80, 2005 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-16264049

RESUMO

The aim of the present study was to investigate the frequencies of asbestos-related benign pleural diseases in villagers environmentally exposed to asbestos and the factors affecting these frequencies. A field-based, cross-sectional study was designed. In total, 991 villagers from 10 villages, randomly chosen from 67 villages with known use of asbestos-containing white soil in central Anatolia (Turkey), were investigated. The type of asbestos in the white soil was determined for each village, as well as air-borne fibre concentrations. The villagers were investigated with small-size chest roentgenograms and epidemiological features were recorded. The air-borne fibre levels were generally low. Despite this, pleural plaques were found in 14.4% of the villagers, 10.4% had diffuse pleural fibrosis and 0.4% asbestosis. The significant variables for plaques were age, sex, type of asbestos fibre, e.g. actinolite and tremolite, and exposure duration, while there was a negative relationship with cumulative exposure. The variables affecting diffuse pleural fibrosis were age, exposure duration and cumulative exposure. In conclusion, villagers exposed to environmental asbestos have high frequencies of pleural plaques and diffuse pleural fibrosis, similar to occupationally exposed asbestos cohorts. Different types of asbestos appear to result in different frequencies of pleural lesions.


Assuntos
Poluentes Atmosféricos/análise , Amianto/análise , Exposição Ambiental/análise , Doenças Pleurais/epidemiologia , Medição de Risco/métodos , População Rural/estatística & dados numéricos , Poluentes do Solo/análise , Adulto , Distribuição por Idade , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Prognóstico , Fatores de Risco , Distribuição por Sexo , Turquia/epidemiologia
3.
Respir Med ; 95(10): 829-35, 2001 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-11601750

RESUMO

The aim of this study was to investigate the effects of various pretreatment clinical and laboratory characteristics on the survival of patients with diffuse malignant pleural mesothelioma (DMPM). One hundred histopathologically confirmed DMPM patients were evaluated. Fifty-nine were treated with chemoimmunotherapy while 41 who had refused chemoimmunotherapy received supportive therapy alone. The following pretreatment characteristics were evaluated in both univariate and multivariate Cox regression analyses: age, gender, Karnofsky performance score (KPS), histology asbestos exposure, presence of chest pain, dyspnoea, weight loss, symptom duration, smoking history, disease location, platelet count, haemoglobin, white blood cell (WBC) count, serum lactate dehydrogenase (LDH) and extent of disease (stage). Univariate analysis showed that patients with age > or = 75 years, male gender, smoking history advanced stages above stage I disease, KPS < 70, WBC count > or = 8450 and LDH level > or = 500 IU l(-1) have a worse prognosis. With multivariate Cox regression analyses, age > or = 75 years, advanced stages above stage I disease, KPS < 70 and LDH level > or = 500 IU l(-1) were found to be indicators of a poorer prognosis. In conclusion, in our study each of low performance status, older age, advanced stage disease, high LDH level and prognosis were found to be related.


Assuntos
Neoplasias Pulmonares/mortalidade , Mesotelioma/mortalidade , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Análise de Variância , Amianto , Dor no Peito/etiologia , Dispneia/etiologia , Exposição Ambiental , Feminino , Humanos , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/patologia , Masculino , Mesotelioma/complicações , Mesotelioma/patologia , Pessoa de Meia-Idade , Prognóstico , Modelos de Riscos Proporcionais , Análise de Regressão , Fatores Sexuais , Fumar/efeitos adversos , Taxa de Sobrevida , Fatores de Tempo , Redução de Peso
4.
Lung Cancer ; 31(1): 9-16, 2001 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11162861

RESUMO

The aim of this study was to evaluate the individual and combined diagnostic utility of six tumor markers in patients with pleural effusion. Pleural and serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 15-3 (CA 15-3), carbohydrate antigen 19-9 (CA 19-9), cytokeratin fragment 19 (CYFRA 21-1), neuron-specific enolase (NSE) and total sialic acid (TSA) were assayed in 74 patients with pleural effusions (44 malignant and 30 benign). All tumor markers except TSA and NSE were increased in both serum and pleural fluid of patients with malignant diseases. Using the cut-off values 3 ng/ml, 14 U/ml, 5 U/ml, 8 ng/ml and 70 mg/dl for pleural fluid CEA, CA 15-3, CA 19-9, CYFRA 21-1 and TSA, respectively, the sensitivity (%) and specificity (%) of these tumor markers were as follows: CEA; 52/77, CA 15-3; 80/93, CA 19-9; 36/83, CYFRA 21-1; 91/90, TSA; 80/67, for differentiating malignant effusions from benign. When CA 15-3 and CYFRA 21-1 combined, the sensitivity and specificity were increased (100 and 83%, respectively). Classifying the malignant effusions as bronchial carcinoma and malignant pleural mesothelioma, CEA was shown to have the highest sensitivity and specificity (88 and 90%, respectively) while the combination of CEA with other tumor markers increased sensitivity but decreased specificity. According to our results, tumor markers are not suitable for the differential diagnosis of malignancy.


Assuntos
Biomarcadores Tumorais/análise , Neoplasias da Mama/diagnóstico , Carcinoma/diagnóstico , Neoplasias Pulmonares/diagnóstico , Mesotelioma/diagnóstico , Derrame Pleural/imunologia , Adolescente , Adulto , Idoso , Neoplasias da Mama/imunologia , Carcinoma/imunologia , Feminino , Humanos , Neoplasias Pulmonares/imunologia , Masculino , Mesotelioma/imunologia , Pessoa de Meia-Idade , Sensibilidade e Especificidade
5.
Artigo em Inglês | MEDLINE | ID: mdl-10923591

RESUMO

Allergy to cockroach and latex are said to be causes of asthma particularly in some groups. We studied allergy to cockroach and latex in asthmatic patients from Eskisehir (Anatolia), Turkey in order to determine whether these allergens play an important role in the Anatolian region. A total of 216 asthmatic patients (mean age 43.7+/-11.0 years) were skin tested with common aeroallergens, Blatella germanica and latex. Sixty-three patients were allergic (29.1%) and 153 were nonallergic (70.8%) according to skin test results. Sensitization to pollens (57%) and mites (55.5%) was most common among allergic patients. We found a low sensitization to cockroach (4.7%) and latex (1.4%). We suggested that cockroach sensitization plays a small role in sensitization in our geographic area and that latex sensitization is low in allergic asthmatic patients who were referred for reasons other than latex-related symptoms.


Assuntos
Asma/epidemiologia , Baratas/imunologia , Hipersensibilidade ao Látex/epidemiologia , Adolescente , Adulto , Fatores Etários , Idoso , Animais , Asma/sangue , Asma/etiologia , Asma/imunologia , Feminino , Humanos , Imunoglobulina E/sangue , Imunoglobulina E/imunologia , Hipersensibilidade ao Látex/sangue , Hipersensibilidade ao Látex/etiologia , Hipersensibilidade ao Látex/imunologia , Masculino , Pessoa de Meia-Idade , Prevalência , Turquia/epidemiologia
6.
Respiration ; 66(1): 88-90, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-9973700

RESUMO

Tuberculous infection of the esophagus is a rare disease and usually occurs secondary to tuberculous mediastinal lymphadenopathy. We report a 74-year-old woman presenting with dysphagia and weight loss. The chest radiograph showed punctuated calcifications lining from the right hilar region to the paracardiac region. Upper gastrointestinal endoscopy revealed a 0.5 x 5 cm lesion localized in the 25th cm of the esophagus covered partly with normal mucosa, partly demonstrating ulcerous areas. Biopsy revealed granulomatous infiltrates being tuberculoid in type. Thorax CT showed a calcified lymph node at the right hilum. The patient did not give consent to therapy and died 1 month later.


Assuntos
Doenças do Esôfago/microbiologia , Tuberculose , Idoso , Doenças do Esôfago/diagnóstico , Doenças do Esôfago/diagnóstico por imagem , Evolução Fatal , Feminino , Humanos , Tomografia Computadorizada por Raios X , Tuberculose/diagnóstico , Tuberculose/diagnóstico por imagem
7.
Clin Chim Acta ; 264(2): 149-62, 1997 Aug 29.
Artigo em Inglês | MEDLINE | ID: mdl-9293374

RESUMO

The differentiation of pleural effusions as being either transudate or exudate is the first step in the diagnosis of pleural effusions. The aim of this study was to compare the efficiency of the various biochemical parameters to the traditional criteria of Light et al., for differentiating exudates from transudates. Ninety-three pleural fluid and sera specimens were obtained and classified as transudates or exudates on the basis of their diagnosis. Of the 93 pleural fluids, 21 were transudates, 72 were exudates. The efficiencies of different parameters for detection of exudates were as follows: The criteria of Light 96%; effusion cholesterol concentration 77%; serum-fluid albumin gradient 67%, pleural/serum alkaline phosphatase ratio 83%; effusion creatine kinase levels 91%; pleural/serum creatine kinase ratio 83%, and effusion uric acid 71%. Pleural/serum uric acid ratio was insignificant for the purpose of this study.


Assuntos
Albuminas/análise , Fosfatase Alcalina/análise , Bilirrubina/análise , Colesterol/análise , Creatina Quinase/análise , Exsudatos e Transudatos/química , Derrame Pleural/diagnóstico , Ácido Úrico/análise , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Fosfatase Alcalina/sangue , Bilirrubina/sangue , Proteínas Sanguíneas/análise , Colesterol/sangue , Creatina Quinase/sangue , Diagnóstico Diferencial , Feminino , Humanos , L-Lactato Desidrogenase/análise , L-Lactato Desidrogenase/sangue , Masculino , Pessoa de Meia-Idade , Derrame Pleural/química , Albumina Sérica/análise , Ácido Úrico/sangue
8.
J Comput Assist Tomogr ; 19(3): 370-4, 1995.
Artigo em Inglês | MEDLINE | ID: mdl-7790544

RESUMO

OBJECTIVE: Our goal was to determine the sensitivity of CT-guided closed pleural needle biopsy (CPNB) for the histopathologic diagnosis of diffuse malignant pleural mesothelioma (DMPM). MATERIALS AND METHODS: Thirty patients with DMPM were studied with CT-guided CPNB. Tumor specimens were classified according to their cell types. RESULTS: In 25 (83.3%) patients, the diagnosis was made by CT-guided CPNB. The remaining five patients were diagnosed by thoracoscopy, thoracotomy, or excisional biopsy of the chest wall mass. Pneumothorax was observed in 9.5% of patients and local seeding of tumor in 21.7% of patients who underwent CPNB. CONCLUSION: Properly performed CPNB under CT guidance may yield an increased sensitivity for the diagnosis of diffuse malignant pleural mesothelioma.


Assuntos
Mesotelioma/diagnóstico por imagem , Mesotelioma/patologia , Neoplasias Pleurais/diagnóstico por imagem , Neoplasias Pleurais/patologia , Tomografia Computadorizada por Raios X/métodos , Adulto , Idoso , Biópsia por Agulha/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos
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