1.
Bioorg Med Chem Lett
; 21(7): 2011-6, 2011 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21354795
RESUMO
A high-throughput screening campaign has identified 1,4-diazepane compounds which are potent Cannabinoid receptor 2 agonists with excellent selectivity against the Cannabinoid receptor 1. This class of compounds suffered from low metabolic stability. Following various strategies, compounds with a good stability in liver microsomes and rat PK profile have been identified.