1.
Bioorg Med Chem Lett
; 18(21): 5758-62, 2008 Nov 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18835709
RESUMO
A novel series of pyrazolo[1,5-b]pyridazines have been synthesized and identified as cyclin dependant kinase inhibitors potentially useful for the treatment of solid tumors. Modification of the hinge-binding amine or the C(2)- and C(6)-substitutions on the pyrazolopyridazine core provided potent inhibitors of CDK4 and demonstrated enzyme selectivity against VEGFR-2 and GSK3beta.