Pediatric and psychiatric models of autism care in Mexico: Differences in diagnostic tools and prescribed interventions.

Low- and middle-income countries face heterogeneity in the way clinicians' approach Autism Spectrum Disorder (ASD) diagnosis and treatment. The current study analyzes the diagnostic tools, laboratory tests, pharmacological and psychosocial interventions received by patients during the steps to diagnosis and treatment of two specialized care centers. Researchers interviewed families with a child with ASD receiving services at either a child psychiatric or a pediatric hospital. Of the total sample, 47% reported clinicians not using a diagnostic tool, 20% reported not receiving any psychosocial intervention, and 88% reported receiving a pharmacological prescription. Patients at the pediatric hospital were more likely to receive interventions with some components of Applied Behavioral Analysis, Early Start Denver Model, Treatment and Education of Autistic and Related Communication Handicapped Children, and Sensory integration therapy; while patients at the psychiatric hospital were more likely to undergo learning, daily living skills, and socialization therapies. Patients at the psychiatric hospital received significantly more requests to obtain auditory and vision tests whilst genetic testing and imaging were more common in the pediatric hospital. The range and variability in terms of diagnostic tools, laboratory tests, and treatment options observed for both sites reflect a lack of consensus. Recommendations to improve ASD diagnostic and treatment in Mexico are given.

Epigenome-Wide Analysis Reveals DNA Methylation Alteration in ZFP57 and Its Target RASGFR2 in a Mexican Population Cohort with Autism.

Autism Spectrum Disorders (ASD) comprise a group of heterogeneous and complex neurodevelopmental disorders. Genetic and environmental factors contribute to ASD etiology. DNA methylation is particularly relevant for ASD due to its mediating role in the complex interaction between genotype and environment and has been implicated in ASD pathophysiology. The lack of diversity in DNA methylation studies in ASD individuals is remarkable. Since genetic and environmental factors are likely to vary across populations, the study of underrepresented populations is necessary to understand the molecular alterations involved in ASD and the risk factors underlying these changes. This study explored genome-wide differences in DNA methylation patterns in buccal epithelium cells between Mexican ASD patients (n = 27) and age-matched typically developing (TD: n = 15) children. DNA methylation profiles were evaluated with the Illumina 450k array. We evaluated the interaction between sex and ASD and found a differentially methylated region (DMR) over the 5'UTR region of ZFP57 and one of its targets, RASGRF2. These results match previous findings in brain tissue, which may indicate that ZFP57 could be used as a proxy for DNA methylation in different tissues. This is the first study performed in a Mexican, and subsequently, Latin American, population that evaluates DNA methylation in ASD patients.

Hispano-American Brain Bank on Neurodevelopmental Disorders: An initiative to promote brain banking, research, education, and outreach in the field of neurodevelopmental disorders.

Neurodevelopmental disorders (NDDs) are conditions that present with brain dysfunction due to alterations in the processes of brain development. They present with neuropsychiatric, cognitive, and motor symptoms. Autism spectrum disorder (ASD) and Fragile X syndrome (FXS) are two of the most common NDDs. Human brain tissue is a scarce resource that is obtained from postmortem donations. In the case of NDDs, specifically autism, the reduced donation rate of brains prevents researchers to investigate its pathology and fine anatomy. The Hispano-American Brain Bank of Neurodevelopmental Disorders (Banco Hispanoamericano de CErebros de trastornos del NEurodesarrollo) or CENE is a large-scale brain bank for neurodevelopmental disorders in Hispano-America and the US. CENE's objectives are to collect and distribute brains of patients with NDDS, with a focus on ASD and FXS, to perform research, promote education of future scientists, and enhance public awareness about the importance of human tissue availability for scientific research on brain function and disease. CENE has thus far established a bilingual system of nodes and teams in several American countries including California-US, Pennsylvania-US, México, Puerto Rico, Colombia, and Dominican Republic. CENE ensures that postmortem NDD samples used in research better match the world's genetic and ethnic diversity. CENE enables and expands NDD brain research worldwide, particularly with respect to ASD and FXS.

Measurement invariance of the Childhood Autism Rating Scale (CARS) across six countries.

The Childhood Autism Rating Scale (CARS) is a simple and inexpensive tool for Autism spectrum disorder (ASD) assessments, with evidenced psychometric data from different countries. However, it is still unclear whether ASD symptoms are measured the same way across different societies and world regions with this tool, since data on its cross-cultural validity are lacking. This study evaluated the cross-cultural measurement invariance of the CARS among children with ASD from six countries, for whom data were aggregated from previous studies in India (n = 101), Jamaica (n = 139), Mexico (n = 72), Spain (n = 99), Turkey (n = 150), and the United States of America (n = 186). We analyzed the approximate measurement invariance based on Bayesian structural equation modeling. The model did not fit the data and its measurement invariance did not hold, with all items found non-invariant across the countries. Items related to social communication and interaction (i.e., relating to people, imitation, emotional response, and verbal and nonverbal communication) displayed lower levels of cross-country non-invariance compared to items about stereotyped behaviors/sensory sensitivity (i.e., body and object use, adaptation to change, or taste, smell, and touch response). This study found that the CARS may not provide cross-culturally valid ASD assessments. Thus, cross-cultural comparisons with the CARS should consider first which items operate differently across samples of interest, since its cross-cultural measurement non-invariance could be a source of cross-cultural variability in ASD presentations. Additional studies are needed before drawing valid recommendations in relation to the cultural sensitivity of particular items.

Pathways to a Diagnosis of Autism Spectrum Disorder.

OBJECTIVE: This study aimed to analyze the pathways to obtaining a diagnosis of autism spectrum disorder (ASD) within the Mexican health system. METHODS: Parents of children with ASD (N=186) were approached at specialized health centers and interviewed about the sequence of professionals they contacted that led to a diagnosis. The authors established the pathway to diagnosis, time of first parental concerns, time of first consultation, age of the child at diagnosis, and other measures. A Sankey plot was used to illustrate the complexity of the pathway to diagnosis. Diagnostic delays among children with autism were compared with delays among subsamples of children with Asperger's syndrome. Regression analysis was used to evaluate the effect of socioeconomic and clinical variables on diagnostic delays. RESULTS: The median diagnostic delay was 27 months (interquartile range [IQR] 8-36), and three professional contacts (IQR 3-6) were needed to achieve a diagnosis. Patients switched between primary and tertiary care even in later stages of the pathway. Patients with Asperger's syndrome had longer delays than patients with autism, and girls and older patients took more time to receive a diagnosis. Parental concerns regarding language, developmental issues, and perceived developmental regression resulted in shorter diagnostic delays. CONCLUSIONS: Pathways to diagnosis of ASD are long and involve multiple contacts, with patients alternating between primary and specialized care. This pattern reflects failures in the diagnostic protocols and referral systems of clinical centers in Mexico, and such issues may be experienced in countries with similarly overwhelmed health care systems.

Advanced paternal age as a risk factor for autism spectrum disorder in a Mexican population / Edad paterna avanzada como factor de riesgo para el trastorno del espectro autista en una población mexicana

Abstract Introduction Risk factors for autism spectrum disorders (ASD) have been identified, as is the case of advanced parental age. Advanced parental age as an ASD risk factor has been studied in Scandinavian populations; there are no reports for Mexican children. Objective The present work aim is to analyze if advanced parental age is a risk factor for ASD in a Mexican children sample. Method Mexican children (N = 1 068) participated in a case-control study, 162 had an ASD diagnosis. Multivariate logistic regression adjusted by cofounders was performed to explore the effect of paternal age on ASD risk. Results Advanced paternal age in Mexican children increases the risk for ASD, and also, a difference of 10 years between parental ages have a higher risk. Discussion and conclusion The effect of advanced paternal age in Mexican children was lower than those reported previously for other populations. Advanced paternal age and difference between parental ages could be a risk factor for ASD in Mexican population. Nevertheless, the analysis of larger sample sizes is required.

Resumen Introducción Se han identificado algunos factores de riesgo para el trastorno del espectro autista (TEA) como es el caso de la edad parental avanzada. La edad parental avanzada es un factor de riesgo que ha sido muy explorado en poblaciones escandinavas; sin embargo, no existen reportes en niños de ascendencia mexicana. Objetivo El presente trabajo tiene el objetivo de analizar si la edad parental avanzada es un factor de riesgo para TEA en una muestra de niños mexicanos. Método Un total de 1 068 niños de la Ciudad de México se incluyeron en un estudio de casos-controles, de los cuáles 162 contaban con diagnóstico de TEA. Regresiones logísticas multivariable, ajustadas por confusores, se realizaron para explorar el efecto de la edad parental avanzada en el riesgo para TEA. Resultados La edad paterna avanzada en niños mexicanos aumentó el riesgo para TEA; también, una diferencia de edad de 10 años entre los padres presenta un mayor riesgo. Discusión y conclusión El efecto de la edad paterna avanzada en los niños mexicanos fue mucho más bajo que aquella reportada para otras poblaciones. La edad paterna avanzada y la diferencia entre la edad parental puede ser un factor de riesgo para TEA en población mexicana. Sin embargo, se requieren análisis en poblaciones con mayor tamaño de muestra.

Are Tattoos an Indicator of Severity of Non-Suicidal Self-Injury Behavior in Adolescents?

OBJECTIVE: To compare adolescents with non-suicidal self-injury behavior and tattoos [NSSI (T+)] with another group with non-suicidal self-injury behavior without tattoos [NSSI (T-)]. METHODS: Adolescents (n=438) 42.6% males from the community (M=12.3, SD=1.3), completed the Self-Injury Schedule. RESULTS: The lifetime prevalence of tattoos performed with the purpose to feel pain was 1.8%. Compared to the NSSI (T-) group, the NSSI (T+) group was significantly more likely to meet the DSM-5 frequency criteria of 5 self-injury events in 1 year, practice more than one method of self-injury, and topography, more suicidal intentionality, more negative thoughts and affective emotions before, during, and after self-injury and more academic and social dysfunction. CONCLUSION: Adolescents from the community who practice tattooing to feel pain, show a distinct phenotype of NSSI. Health professionals and pediatricians should assess tattooing characteristics such as intention (to feel pain), frequency, and presence of non-suicidal self-injury behavior and suicide intentionality.

Brief Report: Macrocephaly Phenotype and Psychiatric Comorbidity in a Clinical Sample of Mexican Children and Adolescents with Autism Spectrum Disorders.

Autism spectrum disorders (ASD) may present with macrocephaly. Few studies have analyzed the association with psychiatric comorbidity. Participants were 94 children with any ASD with an age range from 2 to 16 years (Mdn 6 years), 82% were boys. It was found that 20% of the sample had macrocephaly and 1% microcephaly. There was no association between the presence of macrocephaly and subtype of ASD. The most associated comorbidity was attention-deficit/hyperactivity disorder (ADHD) 54.2%, followed by specific phobia 34%, dysthimia 29.7%, oppositional defiant disorder 13.83% motor tics 11.7%, separation anxiety 9.5% and Gilles de la Tourette 8.5%. In conclusion, macrocephaly and psychiatric comorbidity in this clinical sample of children with ASD is similar to the international literature results.

Consistencia interna y validez de criterio de la versión mexicana del Child Behavior Checklist 1. 5-5 (CBCL/1.5-5) / Internal consistency and criterion validity and reliability of the Mexican Version of the Child Behavior Checklist 1. 5-5 (CBCL/1.5-5)

Objetivo: Investigar la consistencia interna y la validez de la versión mexicana de la lista de síntomas de niños de 1,5 a 5 años de edad del Child Behavior Checklist (CBCL/1.5-5) que mide la psicopatología más común en niños preescolares en el contexto clínico y epidemiológico. Pacientes y método: Diseño transversal, comparativo, en una muestra de 438 padres de 2 grupos: clínico-psiquiátrico (n = 62) y comunitario (n = 376). Se aplicó el instrumento CBCL/1,5-5 adaptado al lenguaje español coloquial mexicano. Para el análisis estadístico se utilizó el coeficiente alfa de Cronbach, prueba de Feldt y correlación de Pearson. Resultados: La consistencia interna para las subescalas fue elevada para problemas totales α = 0,95, internalizados α = 0,89, externalizados α = 0,91. El test-retest mediante el coeficiente de correlación intraclase fue mayor a 0,95 para las subescalas de problemas internalizados, externalizados y totales. La curva de Receiver Operating Characteristic, para el criterio de los grupos referido-clínicamente frente a no-referido para la escala total de problemas ≥ 24 resultó en un área bajo la curva 0,77, especificidad 0,73 y sensibilidad 0,70. Conclusiones: El CBCL/1,5-5/versión mexicana es un instrumento válido y confiable.

Objective: To investigate the validity and internal consistency of the Mexican version of the CBCL/1.5-5 that assesses the most common psychopathology in pre-school children in clinical and epidemiological settings. Patients and method: A total of 438 parents from two groups, clinical-psychiatric (N= 62) and community (N= 376) completed the CBCL/1.5-5/Mexican version. Results: The internal consistency was high for total problems α=0.95, and internalized α=0.89 and externalized α=0.91 subscales. The test re-test (one week) using the intraclass correlation coefficient (ICC) was ≥ 0.95 for the internalized, externalized, and total problems subscales. The ROC curve for the criterion status of clinically-referred vs. non-referred using the total problems scale ≥ 24 resulted in an AUC (area under curve) of 0.77, a specificity 0.73, and a sensitivity of 0.70. Conclusions: The CBCL/1.5-5/Mexican version is a reliable and valid tool.

[Internal consistency and criterion validity and reliability of the Mexican Version of the Child Behavior Checklist 1.5-5 (CBCL/1.5-5)]. / Consistencia interna y validez de criterio de la versión mexicana del Child Behavior Checklist 1.5-5 (CBCL/1.5-5).

OBJECTIVE: To investigate the validity and internal consistency of the Mexican version of the CBCL/1.5 -5 that assesses the most common psychopathology in pre-school children in clinical and epidemiological settings. PATIENTS AND METHOD: A total of 438 parents from two groups, clinical-psychiatric (N= 62) and community (N= 376) completed the CBCL/1.5-5/Mexican version. RESULTS: The internal consistency was high for total problems α=0.95, and internalized α=0.89 and externalized α=0.91 subscales. The test re-test (one week) using the intraclass correlation coefficient (ICC) was ≥ 0.95 for the internalized, externalized, and total problems subscales. The ROC curve for the criterion status of clinically-referred vs. non-referred using the total problems scale ≥ 24 resulted in an AUC (area under curve) of 0.77, a specificity 0.73, and a sensitivity of 0.70. CONCLUSIONS: The CBCL/1.5 -5/Mexican version is a reliable and valid tool.

Autolesiones sin intención suicida en una muestra de niños y adolescentes de la ciudad de México / Nonsuicidal Self-Injury in a Community Sample of Older Children and Adolescents of Mexico City

Introducción: En México como en otros países los estudios no distinguen entre los intentos de suicidio (IS) delas autolesiones con (A+) y sin intención de suicidio (A-). El objetivo de este estudio fue investigar las autolesiones y su prevalencia a partir de varias definiciones, además de estudiar la frecuencia de los criterios propuestos del DSM-5 para las autolesiones sin intención suicida en adolescentes de ambos sexos. Metodología: El estudio fue observacional, descriptivo, transversal, comparativo a partir de una muestra no probabilística de adolescentes de ambos sexos de escuelas secundarias oficiales que contestaron la cédula de autolesiones. Resultados: Los participantes fueron 533 adolescentes con una edad (M=13.37, DE 0.95) y un rango de 11 a 17años, 54% del sexo femenino. La prevalencia de (A-) definida con los criterios de autolesiones propuestos para el DSM-5 fue del 5.6% (N=30), con una definición amplia a partir de sólo el ítem 51(¿Te lastimas sin la intención de quitarte la vida?) fue del 17.1% (N=140), en el último mes (1-3 eventos) fue del 9.9% (N=53), en los últimos 6 meses (1-3 eventos) fue del 11.6% (N=62) y en el último año (5 eventos) fue del 12.6 % (N=67). La edad de inicio fue de 11.9 ± 1.39, (rango 6-15 años). La mayoría de los criterios del DSM-5 tuvieron mayor frecuencia en las niñas que los niños. Conclusiones: Las autolesiones con y sin intención de suicidio son muy frecuentes en la comunidad. Se discuten aspectos importantes para la toma de decisiones en el ámbito escolar y médico

Introduction: In Mexico, as in other countries, studies do not distinguish between attempted suicide and suicidal and non suicidal self-injury (NSSI). The aim of this study was to investigate self-injury and its prevalence using several definitions, in addition to studying the frequency of the proposed DSM-5 criteria for NSSI in adolescent girls and boys. Methodology: The study was observational, descriptive, cross-sectional, and comparative using a nonrandomized sample of adolescent girls and boys from official high schools who completed the self-injury questionnaire. Results: The participants were 533 older children and adolescents with a mean (SD) age of 13.37 (0.95) years, age range 11 to 17 years, and 54% female sex distribution. The prevalence of NSSI defined according to proposed DSM-5 criteria was 5.6% (N=30) and, according to a broad definition using only item 51 ("Do you hurt yourself without intending to end your life?"), 17.1% (N=140). Prevalence defined by the number of events in the last month (1-3 events) was 9.9% (N=53), in the last 6 months (1-3 events), 11.6% (N=62), and in the last year (5 events), 12.6% (N=67).The age at onset was 11.9 (1.39) years (range 6-15 years).Most DSM-5 criteria were more frequent in girls than boys. Conclusions: Suicidal and non suicidal self-injury are frequent in the community. Important points for decision making in schools and medical practice are discussed

Nonsuicidal self-injury in a community sample of older children and adolescents of Mexico City.

INTRODUCTION: In Mexico, as in other countries, studies do not distinguish between attempted suicide and suicidal and nonsuicidal self-injury (NSSI). The aim of this study was to investigate self-injury and its prevalence using several definitions, in addition to studying the frequency of the proposed DSM-5 criteria for NSSI in adolescent girls and boys. METHODOLOGY: The study was observational, descriptive, cross-sectional, and comparative using a nonrandomized sample of adolescent girls and boys from official high schools who completed the self-injury questionnaire. RESULTS: The participants were 533 older children and adolescents with a mean (SD) age of 13.37 (0.95) years, age range 11 to 17 years, and 54% female sex distribution. The prevalence of NSSI defined according to proposed DSM-5 criteria was 5.6% (N=30) and, according to a broad definition using only item 51 ("Do you hurt yourself without intending to end your life?"), 17.1% (N=140). Prevalence defined by the number of events in the last month (1-3 events) was 9.9% (N=53), in the last 6 months (1-3 events), 11.6% (N=62), and in the last year (5 events), 12.6% (N=67). The age at onset was 11.9 (1.39) years (range 6-15 years). Most DSM-5 criteria were more frequent in girls than boys. CONCLUSIONS: Suicidal and nonsuicidal self-injury are frequent in the community. Important points for decision-making in schools and medical practice are discussed.

La integridad mental del personal clínico de un hospital psiquiátrico, asociada a una alta exigencia emocional y a la organización nociva del trabajo / Mental health integrity of clinical staff at a psychiatric hospital, associated to burn-out toxic management

The Joint Committee on Health at Work make up by: ILO/WHO (International Labour Organization and the World Health Organization) in 1992, recognized that inappropriate management, affects people's health through physiological and psychological mechanisms known as stress. The aim of this study was to evaluate the risks associated to toxic management, and to certain psychological demands; as contributors to mental distress, lack of stress and job dissatisfaction of psychiatrists, vitality psychologists and medical residents of a Child Psychiatric Hospital (CHPH). Material and methods The study design was a cross-sectional survey, descriptive and observational. Instrument: The Copenhagen Psychosocial Questionnaire (The Copenhagen Psychosocial Questionnaire COPSOQ). Originally developed in Denmark, was adapted and validated in Spain. The internal consistency of the scales was Cronbach's a (0.66 to 0.92) and Kappa indices (0.69 to 0.77). Statistical analysis. Descriptive analysis was expressed by means, percentages and standard deviations. Bivariate analysis was calculated between psychosocial factors and dimensions of health. The comparisons between categorical variables were analized through chi square tests, and Fisher's exact test was used when the number of observations in the cells of the contingency table was less than 5. The results were expressed by prevalence ratios and their respective confidence intervals were calculated. Statistical analysis was performed using JMP statistical package version 7 and SPSS version 17. Results A total of 111 clinicians were surveyed: 30 psychiatrists, 46 psychologists and 35 medical residents. The response rate was 97%. The age range of the clinical staff was, from 26 to 65 years, with M=40, SD=6.5 years. Association between psychosocial demands and dimensions of health. Major problems presented by clinical staff, were explained from 3 axes. First axis, about psychological demands. We evaluated five types of psychological demands, but those that emerged as predictors of mental distress, loss of energy and cognitive behavioral stress symptoms, were the emotional demands. Emotional demands had statistically significant associations with mental distress (OR 3.67, 95% CI 1.28-10.01), behavioral symptoms (OR 3.59, 95% CI 1.28-10.06) and cognitive stress (RP 2.15, 95% CI 1.00-5.12) as well as lack of vitality (OR 1.78, 95% CI 1.01-3.13) (table4). Second axis: about quality of leadership, this concept showed statistically significant association with: mental distress (OR 2.83, 95% CI 1.19-6.76), with cognitive symptoms (OR 2.33, 95% CI 1.00-5.60) and behavioral stress (RP 2.24, 95% CI 1.06-4.75) and lack of vitality (OR 1.65, 95% CI 1.06-4.75). Other high-risk concept was: Managers' low social support, that showed statistically significant association with job dissatisfaction (OR 3.08, 95% CI 1.41-6.73), lack of vitality (OR 1.41, 95% CI 1.12-1.78) and mental distress (OR 1.39, 95% CI 1.07-1.81). Within the same second axis of analysis, lack of predictability was significantly associated with: mental distress (OR 2.33, 95% CI 1.40-3.88), behavioral symptoms (OR 2.11, 95% CI 1.31-3.41) cognitive stress symptoms (OR 2.07, 95% CI 1.19-3.61), and lack of vitality (OR 1.63, 95% CI 1.17-2.29). Third axis: the effort-reward imbalance; had a statistically significant association between job insecurity and all dimensions of health such as behavioral symptoms of stress (RP 1.97, 95% CI 1.14-3.41), lack of vitality (RP 1.94, 95% CI 1.23 -3.07), mental distress (RP 1.73, 95% CI 1.04-2.88), and cognitive symptoms of stress (RP 1.39, 95% CI 1.12-1.72). But stronger association was found between insecurity and job dissatisfaction (OR 7.65, 95% CI 1.09-53.75). Hence, the lack of esteem was significantly related to mental distress (OR 2.11, 95% CI 1.12-3.95), with behavioral symptoms of stress (OR 1.82, 95% CI 1.03-3.23), and lack of vitality (OR 1.42, 95% CI 1.00-2.11). Discussion According to Karasek-Theorell's theoretical model, high demands, low control and low social support (the combination of these factors brought together the work of psychiatrists, psychologists and residents) this condition represents the greatest risk to health. Clinical professionals are treated disrespectfully, have no appreciation; causing an effort/reward imbalance in their work. Our results are consistent with research conducted with the same instrument in Sweden, Denmark, Serbia, Germany and Spain. These articles found that psychiatrists and psychologists are exposed to high emotional demands. In contrast a high quality management shows clear relationship to mental well-being, with high vitality and acceptable levels of stress. Our findings show that low social support from managers, increase psychosocial risks and stress findings which are consistent with a Chilean study. Although most participants (except residents) have an acceptable job safety almost eight of every ten respondents claimed to be quite concerned about possible changes or delays in salary, or requiring a second job. Security at work is a fundamental aspect of the model of effort-reward-balance. Lack of this characteristic has a negative impact on human health. The human rights organization in Latin America (HR), found that 33% of latino workers expressed "anxiety" because of job insecurity, furthermore recognized the relationship between job insecurity and an increase in cancer and depression. Latino workers seem to be the most affected by new global order, where employment is based on the informal economy. A poll by the Washington Post, Kaiser Family Foundation and Harvard University affirmed that 33% of latinos expressed "anxiety" by job insecurity, compared with 22% of Afro-American and 20% of white people. Complications in health and life prognosis for these workers and their productivity, affects directly the quality care of the patients, beyond production costs. The Chilean analysis concluded that is necessary to give special attention to health sector working population due to the importance of their work. In conclusion, our results suggest that high emotional demands coupled with a poor quality of leadership, characterized by a highly hierarchical power structure, with low esteem, lack of support and unfair treatment was associated with mental distress, and behavioral symptoms of stress and lack of vitality. The total of these deficiencies and their interaction could potentially cause an effort / reward imbalance in clinician work. From the standpoint of prevention, it is about working there; where the exposures have been identified. The risk factors such as stress need to be controlled from its source: toxic management. It seems relevant to include our proposals, in order to improve organization culture and create healthier environments for the staff, so we recommend: 1) A strategic program to protect health of the hospital staff. 2) To assess and reward the efforts, accomplishments, contributions, results and not permanence. 3) Assign a fair wage according to their preparation and the functions performed. 4) It is necessary that managers and middle managers solve conflict well, plan their job correctly and be able to establish proper communication channels with their subordinates. 5) Promote labor stability. 6) Flexible hours, according to the needs of people and not just production. 7) Working conditions should provide development opportunities and the tasks must be varied and meaningful. 8) Promote teamwork, encourage social support and avoid competition. 9) Strengthen the esteem and recognition, including a promotion plan in terms of expectations of each employee. 10) Eliminate highly hierarchical power structures.

El objetivo de esta investigación fue evaluar los riesgos asociados a las formas nocivas de la organización del trabajo, que unidas a ciertas exigencias psicosociales coadyuvan en la génesis del malestar mental, la falta de vitalidad, el estrés y la insatisfacción laboral de los psiquiatras, psicólogos y residentes del Hospital Psiquiátrico Infantil (HPI). Material y métodos El diseño del estudio fue observacional, transversal y descriptivo. Instrumento. El Cuestionario Psicosocial de Copenhague (The Copenhagen Psychosocial Questionnaire CoPsoQ). El instrumento original de origen danés fue adaptado y validado en España, mostrando tener validez y fiabilidad contrastada, con a de Cronbach (0.66 a 0.92) e índices de Kappa (0.69 a 0.77). Resultados Participaron 111 profesionistas, de los cuales 30 son psiquiatras, 46 psicólogos y 35 médicos residentes. Se obtuvo una respuesta del 97%. La edad mínima del personal clínico se ubicó entre 26 a 35 y la máxima de 56 a 65 años, con una M= 40, DE=6.5 años. Asociación entre las exigencias psicosociales y las dimensiones de salud. Los problemas más apremiantes que presentó el personal clínico se explican a partir de tres ejes. Primer eje, de las exigencias psicológicas: las de tipo emocional tuvieron asociaciones estadísticamente significativas con el malestar mental (RP 3.67, IC95% 1.2810.01), con los síntomas conductuales (RP 3.59, IC95% 1.28-10.06) y cognitivos del estrés (RP 2.15, IC95% 1.00-5.12) así como con la falta de vitalidad (RP 1.78, IC95% 1.01-3.13). El segundo eje, de la calidad de liderazgo: mostró asociación estadísticamente significativa con: el malestar mental (RP 2.83, IC95% 1.19-6.76), con los síntomas cognitivos (RP 2.33, IC95% 1.00-5.60) y los conductuales del estrés (RP 2.24, IC95% 1.06-4.75) y con la falta de vitalidad (RP 1.65, IC95% 1.06-4.75). El escaso apoyo social por parte de los jefes, mostró asociación estadísticamente significativa con la insatisfacción laboral (RP 3.08, IC95% 1.41-6.73), la falta de vitalidad (RP 1.41, IC95% 1.12-1.78) y el malestar mental (RP 1.39, IC95% 1.071.81). Dentro del segundo eje de análisis, la falta de previsibilidad mostró asociación estadísticamente significativa con: el malestar mental (RP 2.33, IC95% 1.40-3.88), con los síntomas conductuales (RP 2.11, IC95% 1.31-3.41) y con los síntomas cognitivos del estrés (RP 2.07, IC95% 1.19-3.61), así como con la falta de vitalidad (RP 1.63, IC95% 1.17-2.29). Tercer eje, del equilibrio esfuerzo-recompensa: se observó asociación estadísticamente significativa entre la inseguridad laboral y todas las dimensiones de salud (síntomas conductuales del estrés (RP 1.97, IC95% 1.14-3.41); falta de vitalidad (RP 1.94, IC95% 1.23-3.07); malestar mental (RP 1.73, IC95% 1.04-2.88) y síntomas cognitivos del estrés (RP 1.39, IC 95% 1.12-1.72). Sin embargo, la asociación de mayor fuerza se observó entre la inseguridad y la insatisfacción laboral (RP 7.65, IC95% 1.09-53.75). Por lo que se refiere a la falta de estima, ésta se asoció en forma significativa con el malestar mental (RP 2.11, IC 95% 1.12-3.95), con los síntomas conductuales del estrés (RP 1.82, IC95% 1.03-3.23) y con la falta de vitalidad (RP 1.42, IC95% 1.00-2.11). Discusión La existencia de la organización nociva en el hospital se explica por medio del modelo demanda-control-apoyo social, en donde los clínicos se exponen a una alta demanda emocional, falta de control y autonomía en el trabajo, aunado a un bajo apoyo social. Esta condición representa la situación de mayor riesgo para su salud. La carencia de respeto, la falta de reconocimiento y el trato injusto podrían ser el origen de un desequilibrio en el esfuerzo-recompensa del trabajo clínico. La pobre calidad de liderazgo, caracterizada por una estructura organizacional y de poder altamente jerarquizada, sumada a la falta de apoyo social, a la inseguridad laboral y a la falta de previsibilidad están afectando de forma muy importante la salud mental de los clínicos del HPI al crear un clima organizacional negativo que contribuye al ausentismo, a la baja productividad y muy probablemente perturba la calidad de la atención a los pacientes. Es necesario, por esto, proteger la integridad mental del personal del hospital.

M-CHAT Mexican Version Validity and Reliability and Some Cultural Considerations.

The Modified Checklist for Autism in Toddlers (M-CHAT) questionnaire is a brief measure available in Spanish which needs to be validated for the Mexican population. Parents of children from (1) community with typical development (TD) and (2) psychiatric outpatient unit completed the CBCL/1.5-5 and the Mexican/MM-CHAT-version. The study sample consisted of 456 children (age M = 4.46, SD = 1.12), 74.34% TD children and 26.65% with Autism Spectrum Disorders (ASD). The MM-CHAT mean score for failed key items was higher for the ASD group compared with the TD group. Internal consistency for the Mexican/M-CHAT version was .76 for total score and .70 for the 6 critical items. Correlations between the MM-CHAT and the CBCL/1.5: PDD and Withdrawn subscales and with ADI-R dimensions: B non verbal) and A were high, and were moderate with ADI-R dimensions B1 (verbal) and C The failure rate of the MM-CHAT between the groups did not reproduce all the critical items found in other studies. Although the instrument has good psychometric properties and can be used for screening purposes in primary settings or busy specialized psychiatric clinics, these results support evidence for cultural differences in item responses, making it difficult to compare M-CHAT results internationally.

Autistic spectrum disorders: Diagnostic and therapeutic challenges in Mexico / Trastornos del espectro autista: retos diagnósticos y terapéuticos en el contexto de México

Autistic Spectrum Disorders (ASD) are developmental disorders with impairments in three broad domains: social interaction, communication and stereotypic movements and repetitive behavior. Their symptoms are complex, bizarre and most of them persistent, causing maladaptive and poor psychosocial adjustment. Early detection and diagnosis is a priority in ASD, parents are the first to notice early autism symptoms: 50% observe signs in the first 12 months of age. Despite initial observations of atypical development, there are significant delays in seeking proper medical attention and correct diagnosis; less than 38% of families receive their diagnosis through health services. Educational and health primary care providers need training in developmental milestones with focus on language and socio-communicative domains. Health policy planners should facilitate rationale referral when key symptoms such as language alterations are detected. The use of valid instruments and surveillance approaches versus awareness through red flag symptoms is discussed. Psychosocial interventions are the most important treatment, with ABA and TEACHH techniques recommended; pharmacological treatment (atypical antipsychotics, antidepressants, drugs for hyperactivity, sleep problems and anxiety) must be directed to treat comorbid conditions and combined with behavioral interventions.

Los trastornos del espectro autista (TEA) son trastornos del desarrollo con alteración en tres dominios: interacción social, comunicación y conductas repetitivas o movimientos estereotipados. Los síntomas son complejos, bizarros y la mayoría persistentes y causan un pobre ajuste psicosocial. La detección y diagnóstico tempranos son prioridad en los TEA; los padres son los primeros en advertir los síntomas tempranos del autismo: 50% observan manifestaciones en los primeros doce meses de edad. A pesar de las observaciones tempranas del desarrollo atípico, existen atrasos en la búsqueda de atención médica apropiada. Los proveedores de servicios educativos y cuidados primarios en salud necesitan adiestramiento en los hitos del desarrollo enfocados en el lenguaje y dominios sociocomunicativos. Se discute el uso de instrumentos y protocolos de abordaje frente a programas sobre advertencia de los síntomas de alarma. Las intervenciones médicas y psicosociales se describen de acuerdo con un abordaje de manejo integral. Las intervenciones psicosociales son las más importantes, en particular el empleo de los programas conocidos como ABA y TEACHH. El tratamiento farmacológico debe combinarse con intervenciones conductuales y utilizarse para el manejo de la comorbilidad.

[Bullying and its association with psychiatric disorders in a Mexican students sample]. / El acoso escolar (bullying) y su asociación con trastornos psiquiátricos en una muestra de escolares en México.

OBJECTIVE: To study the relationship between bullying behavior and psychopathology. MATERIALS AND METHODS: A total of 1 092 students identified their peers' bullying status based on the Bull-S questionnaire. Parents completed the Child Behavior Checklist (CBCL) to determine psychopathology levels. RESULTS: The bullying group had associations with anxiety, somatic symptoms, oppositionalism and behavior problems; the bully-victims group had associations with attention, oppositionalism and behavior problems; victims had higher anxiety scores.These differences were significant compared with the control group. CONCLUSIONS: Bullying is associated with psychopathology, which requires timely psychiatric attention.