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Bioanalysis ; 15(3): 177-191, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36917553

RESUMO

As the desire for a shortened design/make/test/learn cycle increases in early drug discovery, the pressure to rapidly deliver drug metabolism pharmacokinetic data continues to rise. From a bioanalytical standpoint, in vitro assays are challenging because they are amenable to automation and thus capable of generating a high number of samples for analysis. To keep up with analysis demands, automated method development workflows, rapid sample analysis approaches and efficient data analysis software must be utilized. This work provides an outline of how we implemented those three aspects to provide bioanalytical support for in vitro drug metabolism pharmacokinetic assays, which include developing hundreds of mass spectrometry methods and analyzing thousands of samples per week, while delivering a median bioanalytical turnaround time of 1-2 business days.


Assuntos
Descoberta de Drogas , Software , Descoberta de Drogas/métodos , Espectrometria de Massas/métodos , Automação , Projetos de Pesquisa
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