RESUMO
An electron-optical study on the endometrium of 5 controls and 25 patients subjected during 3-12 months to 0.25 mg norgestrel + 0.05 mg etinil-estradiol association treatment is performed. The most prominent electronmicroscopical features of endometrial changes are described, such as the asynchronical maturation of the epithelium and the stroma, the shorthening of the proliferative and secretory phases and the epithelial involution towards the last days of the cycle. Special emphasis is placed on the zonal distribution of these changes. An increase of the nostocitosis phenomena is reported and its significance as a complementary contraceptive mechanism is discussed.
PIP: The results of electron microscope studies on the endometrium of 30 women are reported. 25 took a dose of .25 mg norgestrel and .05 mg ethinyl estradiol as an oral contraceptive for a minimum of 3 months and a maximum of 12; the other 5 served as controls. Examinations were made on the 5th, 10th, 19th, and 25th days of the cycle. The authors intended to establish the electron microscopic basis of changes in the endometrium occurring as a result of taking oral contraceptives, to discuss the findings of others in light of their results, and to discuss the possible role of endometrial modifications on the contraceptive effe ct of the drugs. The most prominent endometrial changes are described, such as the asynchronal maturation of the epithelium and the stroma, the shortening of the proliferative and secretory phases and the epithelial involution toward the last days of the cycle. Special emphasis is placed on the zonal distribution of these changes. An increase in the nostocitosis phenomena is reported and its significance as a complementary contraceptive mechanism discussed.
