Serum gastrin concentrations in healthy males and females of various ages.

We measured, by the RIA method, the concentrations of serum gastrin in a fasting state in 80 healthy volunteers of both sexes (M = 43, F = 37) aged 15-81 years. We did not find significant differences in the mean values of gastrin among them and the correlation of gastrin with the ages was insignificant. Further study of various age groups (15-29, 30-59, greater than 60 years) in both sexes and of two more age groups (18-45, 46-71) in the females, did not disclose any significant differences either. People of ages greater than 60 years had the greatest concentration of gastrin. Furthermore, we studied the concentrations of gastrin in the sera of 39 of these 80 people (M = 23, F = 16), aged 15-47 years, 10 min. and 40 min. after a test meal. No differences were found between the two sexes. However, although the mean levels of gastrin were significantly increased 10 min and 40 min after the meal in comparison with the fasting levels in both sexes, only in the men was the increase after 40 min. significantly greater than that after 10 min.

Serum gastrin concentrations in healthy people of the various ABO blood groups.

The concentrations of gastrin were measured by the RIA method in the sera of 121 healthy Greek volunteers of both sexes and of different ABO blood groups, aged 20--70 years. The determinations took place in a fasting state in all the individuals and 10 min and 40 min after a test meal in 42 of them. No significant differences were found in the mean concentrations of gastrin in the fasting state and after the meal between the various ABO groups. There was an increase in the mean concentrations of gastrin in all the groups after the meal. Nevertheless, this was significant 40 min after the meal in the groups A and B whilst in the group O and in the groups A, B and AB considered together this significant increase had appeared already 10 min after the meal.