RESUMO
A study of the effectiveness of long-term (within a year) use cytoprotector neuropeptide nature of the drug cortexin (in the acute, early and late recovery periods) on the dynamics of the cognitive status of patients with ischemic stroke. The study involved 80 patients first ischemic stroke (IS). The patients of the main group (40 patients) received standard therapy cortexin + 10 mg once a day intramuscularly for 10 days with the same course again at 3, 6, 9 months during the year, the control group (40 people) - basic and vascular therapy for year. Four-time reception cortexin for a year at 10 mg once a day for 10 days promotes regression pronounced movement disorders, stabilize and restore cognitive function, and minimize the likelihood of post-stroke cognitive impairment during the recovery period.
Assuntos
Isquemia Encefálica/complicações , Transtornos Cognitivos/tratamento farmacológico , Cognição/fisiologia , Peptídeos/administração & dosagem , Recuperação de Função Fisiológica , Adulto , Idoso , Isquemia Encefálica/fisiopatologia , Transtornos Cognitivos/etiologia , Transtornos Cognitivos/fisiopatologia , Relação Dose-Resposta a Droga , Feminino , Seguimentos , Humanos , Injeções Intramusculares , Peptídeos e Proteínas de Sinalização Intercelular , Masculino , Pessoa de Meia-Idade , Resultado do TratamentoRESUMO
In adult patients with different variants of the complicated course of bronchitis (prolonged, relapsing, chronic) respiratory syncytial (RS) virus infections were shown to occur very frequently (37-72%, depending on the form on bronchitis). In 220 cases of RS infection the content of anti-RS-virus IgE in the blood was analyzed. The reaction of specific IgE was more pronounced in RS infection observed in patients with acute of bronchitis, than in those with chronic forms. The occurrence of RS-virus infections and reinfections was shown to be directly related to the presence of the broncho-obstructive syndrome in patients. The direct correlation between high levels of serum anti-RS-virus IgE and the presence of bronchospasms in patients, revealed in this study, was indicative of the possible pathogenetic role of this immunoglobulin: the Pearson association factor (rA) was 0.32, p < 0.01. Depending on the specific features of the clinical course of bronchitis, differences in the dynamics and speed on immune response, in the duration of the preservation of anti-RS-virus IgE in the blood, as well as in the character of the reaction of this immunoglobulin to single and multiple RS-virus lesion, were observed.
Assuntos
Anticorpos Antivirais/sangue , Bronquite/imunologia , Imunoglobulina E/sangue , Infecções por Vírus Respiratório Sincicial/imunologia , Vírus Sincicial Respiratório Humano/imunologia , Doença Aguda , Adulto , Antígenos Virais/sangue , Espasmo Brônquico/etiologia , Espasmo Brônquico/imunologia , Bronquite/etiologia , Distribuição de Qui-Quadrado , Doença Crônica , Humanos , Pessoa de Meia-Idade , Recidiva , Infecções por Vírus Respiratório Sincicial/complicaçõesRESUMO
46 patients with ischaemic heart disease were treated with Micristin (20-40 mg/kg) or a combination of Micristin and Propranolol (80-120 mg/die). The values of bleeding time, the platelet factor 4 in lysate of thrombocytes or in plasma of patients as well as the soluble fibrin monomer complexes were investigated. They showed no obvious correlation to the clinical findings.