RESUMO
On the basis of 1800 examinations of tumor cells the authors show possibility for accumulation of luminescent dye uranine by malignant cells. The conception of the mechanism of its accumulation, confirmed by the studies of reinoculated tumors of rats (60 examinations) is presented. Of 821 patients with ulcers of the stomach 641 had no luminescence; at repeated examination cancer and ulcer were revealed in 7 of them. Malignant transformation was verified by histologic method in 102 of 180 patients with luminescent ulcers. In 22 patients intestinal metaplasia was detected in the luminescence areas and in 40--there was a rough epitnelial dysplasia. At the examination of these patients two years later, cancer of the stomach at the sites of previously revealed luminescence was detected in 15 patients (26.3%).
Assuntos
Meios de Contraste , Fluoresceína , Gastroscopia/métodos , Medições Luminescentes , Úlcera Gástrica/diagnóstico , Animais , Diagnóstico Diferencial , Seguimentos , Humanos , Ratos , Neoplasias Gástricas/diagnósticoRESUMO
The effectiveness of a fluorescent analysis in the diagnosis of gastric cancer was studied in 280 patients. Fluorescence of a tumor was noted in 87% of cases. Dependence of fluorescence of a tumor on its sizes was revealed: in tumor diameter less than 1 cm, fluorescence was revealed in 94% of cases, more than 4 cm--in 76%. In infiltrative growth, only 74% of tumors were fluorescent. To define the possibility of the use of a fluorescent analysis in the differential diagnosis of gastric diseases, 490 patients with presumptive diagnosis of chronic gastritis, gastric ulcer disease, polyposis were examined. In diagnosis of +malignant polyps in 91.5% of cases, results of the fluorescent analysis concurred with the findings of histologic study. Probability of establishing the correct diagnosis by the data of fluorescent analysis in ulcer disease is equal to 87.5%, in chronic gastritis--86%.
