Device for remote and realtime monitoring of neonatal vital signs in neonatal intensive care unit using internet of things: proof-of-concept study.

BACKGROUND: Realtime and remote monitoring of neonatal vital signs is a crucial part of providing appropriate care in neonatal intensive care units (NICU) to reduce mortality and morbidity of newborns. In this study, a new approach, a device for remote and real-time monitoring of neonatal vital signs (DRRMNVS) in the neonatal intensive care unit using the internet of things (IoT), was proposed. The system integrates four vital signs: oxygen saturation, pulse rate, body temperature and respiration rate for continuous monitoring using the Blynk app and ThingSpeak IoT platforms. METHODS: The Wemos D1 mini, a Wi-Fi microcontroller, was used to acquire the four biological biomarkers from sensors, process them and display the result on an OLED display for point of care monitoring and on the Blynk app and ThingSpeak for remote and continuous monitoring of vital signs. The Bland-Altman test was employed to test the agreement of DRRMNVS measurement with reference standards by taking measurements from ten healthy adults. RESULTS: The prototype of the proposed device was successfully developed and tested. Bias [limits of agreement] were: Oxygen saturation (SpO2): -0.1 [- 1.546 to + 1.346] %; pulse rate: -0.3 [- 2.159 to + 1.559] bpm; respiratory rate: -0.7 [- 0.247 to + 1.647] breaths/min; temperature: 0.21 [+ 0.015˚C to + 0.405˚C] ˚C. The proof-of-concept prototype was developed for $33.19. CONCLUSION: The developed DRRMNVS device was cheap and had acceptable measurement accuracy of vital signs in a controlled environment. The system has the potential to advance healthcare service delivery for neonates with further development from this proof-of-concept level.

Statistical shape-kinematics models of the skeletal joints: Application to the shoulder complex.

Patient-specific biomechanical simulations of joints require accurate reconstruction of bony anatomy from medical image data. The articular geometries of the joints may influence their biomechanics. Statistical shape models (SSMs) have become ubiquitous in the literature and aim to capture the natural variation of biological objects. They work by learning the variation from training examples to define the space of valid biological shapes. However, the kinematic information descriptive of the anato-physiological relationship of two interacting objects is not generally encoded in the SSM. Here, we propose a framework for developing combined statistical shape and kinematics models (SSKMs) as Gaussian process morphable models to analyse the shape and kinematics relationship. We demonstrate the framework on a three-dimensional (3D) image data set consisting of ten right-handed cadaveric shoulder joints acquired using computed tomography. Additionally, we simulate specific bone motions to encode kinematics in the combined model. Our SSKM built from shoulder data (matching scapulae and humeri) correctly depicts a correlation between the shape and kinematics as hypothesized. We furthermore demonstrate the ability to marginalize from the SSKM to obtain shape-only variation and kinematics-only variation. Future work aims to use the SSKM framework to understand the relationships between kinematics and shape for various joints as well as to develop patient-specific computational models to evaluate joint biomechanics.