Magnitude of Medicine Wastage and Perceived Contributing Factors Among Public Health Facilities in Dire-Dawa City Administration, in Mid COVID-19 Pandemic in Ethiopia: Retrospective, Cross-Sectional Study.

Background: World Health Organization refers medication waste as expired, unused, spilled, and contaminated pharmaceutical items, medications, vaccines, and sera. Budget constraints in financing the health care system together with huge amount of wastage and disposal costs of unused medications at LMIC create a serious risk to the economy, health care system and environment. Thus, the aim of this study was to assess the rate of medication waste and to identify contributing factors in public health facilities in Dire-Dawa city. Methods: An institution-based retrospective, cross-sectional study was supplemented by a qualitative study design from May 10 to June 10, 2021, at 2 public hospitals and 14 health centers. Qualitative data were collected by self-administered questionnaires and 2 years record review. In-depth interviews were used to obtain qualitative data. Excel sheets and SPSS version 20 and thematic analysis were used to analyze quantitative and qualitative data. Results: An average medicine wastage rate was 3.07% between 2010 and 2012 EFY, in Dire-Dawa public health facilities that worth 4,048,594.0 ETB. The most wasted class of medication was anti-infectives, accounting for 2,360,330 ETB (58.3%), while tablets 2,615,391 ETB (64.6%). Medical waste has been linked to several issues, including pushing nearly expired medications to healthcare institutions, lack of clinician involvement in medication selection and quantification, rapid changes in treatment regimens, and the existence of overstocked medication shelves. Conclusion: The average rate of medication waste was higher than the allowed level of 2%. The only medications that should be accepted by medical facilities are those that can be used before they expire. All prescribers should receive lists of the drugs that are readily available from the pharmacy department, and clinicians should be involved in the quantification and drug selection processes to increase the effectiveness of the use of medications.

Determination of Conrad and Curie point depth relationship with the variations in lithospheric structure, geothermal gradient and heat flow beneath the central main Ethiopian rift.

Spectral analysis of the pole reduced magnetic anomaly data and inversion of complete Bouguer anomaly data are employed here as there is no previous published data regarding for the determination of the Curie point depth (CPD), Conrad depth (CD) and lithospheric mantle thickness in the central main Ethiopian rift (CMER) and its environs. The results confirm that the CPD, range between 7.68 and 20.3 km, CD, range between 16 and 25 km and lithospheric mantle thickness, range between 13.4 and 27. 8 km. These results indicate that the CMER magnetic crust occur close to the CD and lithospheric mantle thickness, but below the Moho depth beneath the study area. Based on the results on CPD, we estimate the magnitude of the geothermal gradient and heat flow in the study area. The results confirm that the geothermal gradient, range between 32.4 and 65 °C km-1 and heat flow, range between 80 and 160 mWm-2. These results are found to be inversely correlated with the CPD. It is a commonly known fact that shallow CPDs generate negative magnetization. Similarly, in this study, it is recorded low magnetic anomalies overlap with shallow (less than 13.1 km) CPDs in line with high (110-160 mWm-2) heat flow and high (48-64 °C km-1) geothermal gradient values are determined to occur beneath the CMER. These results associate with the presented geotectonic and geothermal signatures of the study area.

Constrained 3D gravity interface inversion for layer structures: implications for assessment of hydrocarbon sources in the Ziway-Shala Lakes basin, Central Main Ethiopian rift.

Multi layer 3D gravity inversion for layered structures and density interfaces are performed in the Central Main Ethiopian rift bounded between 38000'-39030' E and 7000'-8030' N. The inversion is carried out in wave number domain using Parker-Oldenburg algorithm and is constrained with initial model information. The previous studies in the region focused on mapping crustal structures and Moho depths and least is known about the shallow earth. This study thus targets on mapping layers relief of shallow earth origin. Stacked horizons with depth to tops of density contrast are obtained from well log data and previous geophysical studies. These stacked grids represent major geological boundaries where density contrast exists. The model utilizes observed residual gravity anomaly and generates the structural relief maps of the respective layers with their corresponding gravity anomaly responses and the associated errors. Successive structural inversions are performed on three layers with their corresponding acceptable mean misfits' errors. The iteration process converges successively for each layer in each structural inversion and the result is validated against a priori information. In addition to the topography/thickness of each layers, this study for the first time identified a new Mesozoic horizon laying between a Tertiary ignimbrite layer and the crystalline basement at depths between -2499 m and -3060 m and having estimated maximum thickness of 561 m. The identified Mesozoic sediment formation underlies a thick volcanic cover of 2.5 km which might be a suitable geologic setting for the growth of hydrocarbon reserves in the area and could probably be the source of CO2 degassing.

Depth estimates of anomalous subsurface sources using 2D/3D modeling of potential field data: implications for groundwater dynamics in the Ziway-Shala Lakes Basin, Central Main Ethiopian Rift.

Quantitative analysis of potential field data are made in the Ziway-Shala lakes basin over an area bounded by 38°00' E - 39°30' E and 7°00' N - 8°30' N. Most previous geophysical studies in the region under consideration focus on mapping the deep crustal structures and undulation of the Moho depth. Only few studies are targeted at mapping the shallow subsurface structures. The main focus of this paper is mapping geometries of the major lithological and structural units of the shallow subsurface using gravity and magnetic data. The ultimate objective of the research is to understand the hydrogeological dynamics of the region through mapping interfaces geometries. Automatic inversions, 2D joint forward modeling and 3D inversion are the major techniques employed. The 2D Werner de-convolution based on both gravity and magnetic data along the rift axis showed source depths tending to deepen northwards. Source depths estimates determined by Source Parameter Imaging also showed similar tendency. This is further strengthened by the joint 2D forward modeling of gravity and magnetic data which showed the top of the basement is sloping northwards. The result of the 3D gravity interface inversion agrees with results of the above mentioned depth estimation techniques. Finally, the gravity power spectral analysis resulted in two depth estimates, 1.53 km and 2.87 km which approximate the positions of two density interfaces. The shallow depth interface is thought to presumably delineate the low density Fluvio-lacustrine sediments including the rift floor volcanic units and crystalline basement. Our investigation results agree with the results of previous seismic studies which identified low velocity ("sediment-volcanic") horizon in the rift floor with low resolution. The information obtained with regard to water balance of the basin, salinity level of the lakes and the conceptual hydrological flow model appears to reveal that the groundwater flow in the study region is controlled by subsurface structures, particularly, the mapped interface topographies.

Mapping geologic structures from Gravity and Digital Elevation Models in the Ziway-Shala Lakes basin; central Main Ethiopian rift.

This study attempts to delineate subsurface lineaments for the tectonically and volcanically active region of the Ziway-Shala Lakes basin, central Main Ethiopian rift. Most of the previously mapped subsurface structures in the region under consideration focus on delineating crustal structures thicknesses and Moho depths undulations. Moreover, surface structures in the same region were mapped using analysis of Digital Elevation Model image data. On the other hand, there are few studies that have targeted in mapping geologic structures lying at depth levels between the shallower and deeper subsurface. The objective of this research is thus to map the subsurface geologic structures/lineaments to an average depth of 3 km (crystalline basement layer depth) from surface using gravity data. These investigation results are validated by Digital Elevation Model extracted lineaments. Filtering techniques including derivative filters, upward-continuation and line module algorithm of PCI Geomatica are used to extract the gravity and topographic lineaments of the region. Orientation analyses of these subsurface and surface lineaments are made using line direction histogram of the QGIS software. Accordingly, the gravity subsurface lineaments mapped in this study are found to be dominantly oriented in the NNW-SSE to NW-SE and E-W direction on average. These results appear to be contrary to the NNE-SSW to NE-SW trending surface geologic structure mapped on the bases of actual field observation carried out by previous researchers and automatically extracted lineaments based on Digital Elevation Models data considered in this research. The subsurface lineaments mapped using gravity data are believed to govern groundwater dynamics within the basin and the adjacent basins in the area. These structural lineaments which are considered to be masked in the subsurface coincide with the orientation of the Mesozoic Ogaden rift as compared to the overlying surface structures which appear to coincide with the orientation of the Cenozoic Main Ethiopian rift.

Upward continuation and polynomial trend analysis as a gravity data decomposition, case study at Ziway-Shala basin, central Main Ethiopian rift.

The first task in quantitative interpretation of a gravity data is separation of the Bouguer anomaly into its regional and residual components which are respectively related to deep and shallow subsurface geology. The decomposition process is subjective and non-unique as there is no single best approach to approximate the low frequency signature. For example, the use of spectral analysis and upward continuation require the wise choice of slope change location and continuation height respectively, which could be chosen differently by different researchers. This requires a need to work on more than one method and select the best to be applied for a given study area. The "best" choice is made based on the anomaly signature of the underlying geology. In this research, the most frequently used methods such as upward continuation and trend surface analysis methods are used and compared to approximate the regional field in Central Main Ethiopian rift bounded between 38000'-39030'E and 7000'-8030'N. The upward continuation height and the order of trend polynomial surface are first chosen, to approximate the regional gravity field signal. Accordingly, an upward continuation height of 6km and first order polynomial trend surface are chosen to be appropriate. Comparison of the two methods shows that the upward continuation technique reflects the shallow source anomalies of the area better than that of the first order linear trend surface. This outcome is verified against the result obtained based on the first vertical derivative method, spectral analysis depth estimation method, well-log data and surface geology of the area. It is therefore recommended to consider the various existing filtering techniques and choose the best candidate for the separation of the regional and residual components of the observed field.