Air-Coupled Ultrasonic Arrays for Assessment of Pipe Internal Geometry and Surface Condition.

This article explores what useful information can be retrieved from pipeline interiors using an air-coupled ultrasonic array. Experiments are performed using an array, custom array controller, and supporting electronics controlled by a Raspberry Pi 4, mounted on board a crawler robot. A 64-transducer 40-kHz array configuration is selected based on uniformity of imaging amplitude over the circumference of the pipe wall. Testing revealed joints between pipe sections could be imaged at high amplitude, and that angular displacement between sections produced a different response to a properly aligned joint, potentially enabling detection of faulty joints. The surface roughness of some pipes also provides enough backscatter to be imaged, which is useful for detecting regions of corrosion. It was also found that reflections from the pipe wall in the plane of the array allow imaging of the wall shape. This can indicate the presence of junctions, as well as detect ovality to within 1%. These in-plane wall reflections were also found to be a source of low-amplitude coherent noise throughout the imaging domain, which is of similar amplitude to small (< 10 mm) through-holes in the pipe wall.

In Search of an Academic "Greatest Hits" Album: An Examination of Bibliometrics and Bibliometric Web Platforms.

Despite the relative youth of bibliometric web platforms (Google Scholar was released in 2004), they play an increasingly significant role in the assessment of the impact of scholars and the research they produce. This scholarly essay provides a thorough review of the literature on bibliometric platforms, the extent to which they make available relevant manuscripts for inclusion in research, and their use for the assessment of scholarly work. We describe the metrics found on common bibliometric platforms, proposed metrics not commonly found in platforms, and how those metrics may differ based on scholar race and gender. We identify pitfalls of citation metrics present on bibliometric platforms. Finally, we identify areas for expansion of the research on bibliometric platforms and development of new metrics.

Ultrasonic Nondestructive Characterization of Blockages and Defects in Underground Pipes.

This article explores the use of a 40-kHz air-coupled ultrasonic array in detecting and imaging blockages and defects in buried pipes with 17-26 wavelengths in diameter at short ranges (approximately 20-60 wavelengths). In particular, the imaging performance of arrays with different numbers of transducers is quantified and compared to establish how many are required for adequate performance. Even low numbers of transducers (<25) are capable of producing -6-dB contours of blockages that match reference images to within 95% by restricting the aperture to maintain element density. However, doing so also limits the resolving power, so arrays with more transducers ultimately image better by having great enough density even at larger apertures. Using <25 transducers also gives a poor contrast ratio of features above background noise (as low as 2), resulting in low tolerance for detection and producing unusable images in some cases. More robust performance is achieved with larger numbers of transducers, which achieves sufficient contrast. All images of planar objects feature a low-amplitude band due to interference between direct reflections and reflections via the pipe wall, which was verified by comparison to simulation. When tested in larger pipes in a deployment case, the low-amplitude band was notably larger but was found to decrease in size at longer ranges.

Absence of human T-lymphotropic virus type I tax sequences in a population of normal blood donors in the Baltimore, MD/Washington, DC, area: results from a multicenter study.

BACKGROUND: It was reported recently that sequences corresponding to the human T-lymphotropic virus type I (HTLV-I) tax gene were detected in peripheral blood mononuclear cells from 8 to 11 percent of healthy blood donors without detectable antibodies to HTLV-I. A multicenter blind study was conducted to determine if these results could be independently confirmed. STUDY DESIGN AND METHODS: Specimens were collected from 100 anti-HTLV-I-negative healthy blood donors and from 11 anti-HTLV-I- or anti-HTLV-II-positive individuals. All samples were coded and distributed to each of four independent testing laboratories for polymerase chain reaction analysis to detect sequences of the HTLV-I or HTLV-II tax gene, using detailed procedures specified by the laboratory reporting the original observation. Each laboratory also tested a dilution panel of a plasmid containing HTLV-I tax to determine the analytical sensitivity of the procedure. RESULTS: The analytical sensitivity of the screening methods permitted detection of as few as 1 to 10 copies of the tax gene. However, HTLV-I tax sequences could not be detected in any of the anti-HTLV-I-negative blood donors at more than one test site. CONCLUSION: HTLV-I tax sequences appear not to be present in this population of 100 blood donors negative for anti-HTLV-I.

Induction of tumor necrosis factor alpha in human neuronal cells by extracellular human T-cell lymphotropic virus type 1 Tax.

To examine the role of human T-lymphotropic virus type 1 (HTLV-1) Tax1 in the development of neurological disease, we studied the effects of extracellular Tax1 on gene expression in NT2-N cells, postmitotic cells that share morphologic, phenotypic, and functional features with mature human primary neurons. Treatment with soluble HTLV-1 Tax1 resulted in the induction of tumor necrosis factor alpha (TNF-alpha) gene expression, as detected by reverse-transcribed PCR and by enzyme-linked immunosorbent assay. TNF-alpha induction was completely blocked by clearance with anti-Tax1 monoclonal antibodies. Furthermore, cells treated with either a mock bacterial extract or with lipopolysaccharide produced no detectable TNF-alpha. Synthesis of TNF-alpha in response to soluble Tax1 occurred in a dose-dependent fashion between 0.25 and 75 nM and peaked within 6 h of treatment. Interestingly, culturing NT2-N cells in the presence of soluble Tax1 for as little as 5 min was sufficient to result in TNF-alpha production, indicating that the induction of TNF-alpha in NT2-N does not require Tax1 to be continually present in the culture medium. Treatment of the undifferentiated parental embryonal carcinoma cell line NT2 with soluble Tax1 did not result in TNF-alpha synthesis, suggesting that differentiation-dependent, neuron-specific factors may be required. These results provide the first experimental evidence that neuronal cells are sensitive to HTLV-1 Tax1 as an extracellular cytokine, with a potential role in the pathology of HTLV-1-associated/tropical spastic paraparesis.