Formulation and Evaluation of Amikacin Sulfate Loaded Dextran Nanoparticles against Human Pathogenic Bacteria.

Amikacin sulfate-loaded dextran sulfate sodium nanoparticles were formulated, lyophilized (LADNP), and then analyzed. The LADNP had a -20.9 ± 8.35 mV zeta potential, PDI of 0.256, and % PDI of 67.7. The zeta average nano size of LADNP was 317.9 z. d.nm, while the dimension of an individual particle was 259.3 ± 73.52 nm, and nanoparticle conductivity in colloidal solution was 2.36 mS/cm. LADNP has distinct endothermic peaks at temperatures at 165.77 °C, according to differential scanning calorimetry (DSC). The thermogravimetric analysis (TGA) showed the weight loss of LADNP, which was observed as 95% at 210.78 °C. XRD investigation on LADNP exhibited distinct peaks at 2θ as 9.6°, 10.4°, 11.4°, 18.9°, 20.3°, 24.4°, 28.2°, 33.2°, 38.9°, and 40.4° confirming crystalline structure. The amikacin release kinetics from LADNP revealed zero order kinetics with a linear release showed zero order kinetics with 37% of drug release in 7 h and had an R2 value of 0.99. The antibacterial effect of LADNP showed broad-spectrum activity against tested human pathogenic bacteria. The preset study demonstrated that LADNP is a promising antibacterial agent.

SEM-ANN-based approach to understanding students' academic-performance adoption of YouTube for learning during Covid.

A hybrid analysis of Structural Equation Modeling (SEM) and Artificial Neural Network (ANN), through SmartPLS and SPSS software, as well as the importance-performance map analysis (IPMA) were used to examine the impact of YouTube videos content on Jordanian university students' behavioral intention regarding eLearning acceptance, in Jordan. According to the evaluation of both ANN and IPMA, performance expectancy was the most important and, theoretically, several explanations were provided by the suggested model regarding the impact of intention to adopt eLearning from Internet service determinants at a personal level. The findings coincide greatly with prior research indicating that users' behavioral intention to adopt eLearning is significantly affected by their performance expectancy and effort expectancy. The paper contributed to technology adoption e.g., YouTube in academia, especially in Jordan. Respondents showed a willingness to employ and adopt the new technology in their education. Finally, the findings were presented and discussed through the UTAUT and TAM frameworks.