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1.
Sci Rep ; 14(1): 14684, 2024 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-38918454

RESUMO

Researchers face significant challenges because of the inadequate corrosion resistance and weak adherence of epoxy (EP) coatings. We deal with these issues here by means of a novel nano-composite coating (EP/nano-CoS2). In order to create a composite coating (EP/nano-CoS2), CoS2 nanoparticles (nano-CoS2) were prepared and incorporated to an epoxy (EP) resin. The synthesized CoS2 was characterized using XRD and FT-IR spectroscopic techniques. The mean particle size was determined using Scherer equation and found to be 19.38 nm. The zeta potential was also determined (- 9.78 mV). Electrochemical impedance spectroscopies (EIS) as well as pull-off assessments were used to quantify the EP/nano-CoS2 coating's anti-corrosion capabilities and adhesive power. The findings demonstrate that the EIS variables of the EP/nano-CoS2 composite coating are markedly improved when compared to raw EP coating. The corrosion resistance or even adhesion of EP protective layer can be markedly increased by using the synthesized nanoparticles as nano-fillers.

2.
Sci Rep ; 14(1): 8040, 2024 Apr 05.
Artigo em Inglês | MEDLINE | ID: mdl-38580731

RESUMO

Several environmentally acceptable non-ionic gemini surfactants are synthesized in this work using natural sources, including polyethenoxy di-dodecanoate (GSC12), polyethenoxy di-hexadecanoate (GSC16), and polyethenoxy di-octadecenoate (GSC18). The produced surfactants are confirmed by spectrum studies using FT-IR, 1HNMR, and 13CNMR. It explored and examined how the length of the hydrocarbon chain affected essential properties like foaming and emulsifying abilities. Surface tension examinations are used to assess the surface activity of the examined gemini surfactants. The lower value of critical micelle concentrations (0.381 × 10-4M) is detected for GSC18. Their spontaneous character is shown by the negative values of the free energy of adsorption (ΔGads) and micellization (ΔGmic) which arranged in the order GSC18 > GSC16 > GSC12. Based on theoretical, weight loss, and electrochemical investigations, these novel surfactants were investigated for their possible use in inhibiting carbon steel from corroding in 1 M HCl. Measuring results show that GSC18 inhibits corrosion in carbon steel by 95.4%. The isotherm of adsorption evaluated for the investigated inhibitors and their behavior obeys Langmuir isotherm.

3.
Nanoscale Adv ; 6(5): 1286-1330, 2024 Feb 27.
Artigo em Inglês | MEDLINE | ID: mdl-38419861

RESUMO

Photocatalytic water splitting (PWS) is an up-and-coming technology for generating sustainable fuel using light energy. Significant progress has been made in the developing of PWS innovations over recent years. In addition to various water-splitting (WS) systems, the focus has primarily been on one- and two-steps-excitation WS systems. These systems utilize singular or composite photocatalysts for WS, which is a simple, feasible, and cost-effective method for efficiently converting prevalent green energy into sustainable H2 energy on a large commercial scale. The proposed principle of charge confinement and transformation should be implemented dynamically by conjugating and stimulating the photocatalytic process while ensuring no unintentional connection at the interface. This study focuses on overall water splitting (OWS) using one/two-steps excitation and various techniques. It also discusses the current advancements in the development of new light-absorbing materials and provides perspectives and approaches for isolating photoinduced charges. This article explores multiple aspects of advancement, encompassing both chemical and physical changes, environmental factors, different photocatalyst types, and distinct parameters affecting PWS. Significant factors for achieving an efficient photocatalytic process under detrimental conditions, (e.g., strong light absorption, and synthesis of structures with a nanometer scale. Future research will focus on developing novel materials, investigating potential synthesis techniques, and improving existing high-energy raw materials. The endeavors aim is to enhance the efficiency of energy conversion, the absorption of radiation, and the coherence of physiochemical processes.

4.
Sci Rep ; 14(1): 3535, 2024 Feb 12.
Artigo em Inglês | MEDLINE | ID: mdl-38347018

RESUMO

Co3O4 nanoparticles (Co3O4-NPs) are synthesized using the facile solvothermal method. FT-IR and XRD spectroscopic analyses verify the creation of cobalt oxide nanoparticles with an average size of 13.20 nm. Furthermore, Zeta potential assessments were carried out to identify the electrical charge of the surface of the produced Co3O4-NPs, which was found to be -20.5 mV.  In addition, the average pore size of Co3O4-NPs is 19.8 nm, and their BET surface area is 92.4 m/g. The study also concerned the effect of Co3O4-NPs on epoxy's improvement of mechanical and corrosion protection for carbon steel in salt solution. By including Co3O4-NPs in an epoxy (EP) coating, corrosion is effectively prevented by non-permeable protective coatings that effectively reduce the transfer of corrosion ions and oxygen.

5.
JCO Glob Oncol ; 10: e2300189, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-38166234

RESUMO

PURPOSE: Cancer incidence in Saudi Arabia has recently shown an upward trend. Research efforts within the different cancer continuum are pivotal to strengthening control measures. Since cancer research is evolving in the country, it is crucial to understand the current challenges and implement defined interventions to overcome them. The present qualitative study aimed to assess cancer research barriers among researchers and identify potential solutions from their perspectives. METHODS: We conducted a focus group discussion among 17 Saudi-based cancer researchers from diverse research backgrounds, provinces, and institutions. We used descriptive-interpretive thematic analysis following an open-ended approach to investigate the challenges in conducting cancer research. We also captured the solutions suggested based on the researchers' experiences. RESULTS: Six major themes emerged from the analysis: requirements of the data landscape, organizational support, national research roadmap, sustainable funding, clearer policies and regulations, and capacity building. To address challenges in these areas, researchers stressed the need for improved interinstitutional collaborations, immediate availability of research materials, and unlimited and easy access to research data. CONCLUSION: Improving health research is one of the primary goals of Saudi Vision 2030. It is, therefore, essential to overcome the current challenges in cancer research, enabling research findings to inform policies related to cancer control and care provision.


Assuntos
Atenção à Saúde , Neoplasias , Humanos , Arábia Saudita/epidemiologia , Pesquisa Qualitativa , Neoplasias/epidemiologia , Neoplasias/prevenção & controle
7.
Sci Rep ; 14(1): 1853, 2024 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-38253601

RESUMO

Potentiodynamic study was carried out on nickel in Na2SO4 solution in the presence of ClO4-, WO42-, MoO42-, NO2- and NO3- ions. The anodic excursion spans of the metal nickel in a solution of Na2SO4 are marked by the appearance of clearly defined anodic peak, passive region, and transpassive shoulder. According to the data, the anodic peak current density (IPAI) rise from 1.82 to 8.12 mA cm-2 as the concentration of the Na2SO4 solution rises from 0.2 to 1.0 M. It is clear that as scan rate increases, the IPAI rises reaching to 11.8 mA cm-2. The apparent activation energy of nickel corrosion in Na2SO4 is 33.25 kJ mol-1. ClO4- anion addition speeds up nickel's active dissolution, as well tends to break down the passive layer, and causes pitting penetration. It was found that, the pitting potential (Epit) of nickel in solutions containing the two anions ClO4- and SO42- shifts to the positive direction by addition of WO42-, MoO42-, NO2- anions and shifts to the negative direction by addition NO3- anion. Epit increased by 0.67, 0.37 and 0.15 V in the presence of WO42-, MoO42- and NO2-, respectively. WO42- > MoO42- > NO2- was the order in which the inhibitors were most effective.

8.
Cancers (Basel) ; 15(20)2023 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-37894377

RESUMO

Stereotactic body radiation therapy (SBRT) is a precise and conformal radiation therapy (RT) that aims to deliver a high dose of radiation to the tumor whilst sparing surrounding normal tissue, making it an attractive option for head and neck cancer (HNC) patients who are not suitable for the traditional long course of RT with comprehensive RT target volume. Definitive SBRT for HNC has been investigated in different settings, including early stage glottis cancer, and as an alternative to brachytherapy boost after external beam RT. It is also used as a primary treatment option for elderly or medically unfit patients. More recently, an SBRT combination with immunotherapy in the neoadjuvant setting for HNC showed promising results. Salvage or adjuvant SBRT for HNC can be used in appropriately selected cases. Future studies are warranted to determine the optimum dose and fractionation schedules in any of these indications.

9.
Microbiol Res ; 276: 127481, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37651966

RESUMO

The use of dyes in textile industries has resulted in substantially contaminated soil, water and ecosystem including fauna and flora. So, the application of eco-friendly approach for dyes removal is in great demand. The goal of this research was to develop and test a bacterial consortium for biodegrading dyes in artificial textile effluent (ATE) derived from mixture of Indigo carmine (40 mg/l); Malachite green (20 mg/l); Cotton bleu (40 mg/l); Bromocresol green (20 mg/l) and CI Reactive Red 66 (40 mg/l) dissolved in artificial seawater. The Box-Behnken design (BBD) which combine six variables with three levels each was used to determine the potential removal of dyes in ATE, by the selected microbial consortium (M31 and M69b). The experimental process indicated that decolourization of ATE reached 77.36 % under these conditions values: salinity (30 g/l), pH (9), peptone (5 g/l), inoculum size (1.5 108 CFU/ml), agitation (150 rpm) and contact time (72 h). The decolourization was confirmed by FTIR spectrum analysis of ATE before and after bacterial treatment. Bacterial strains used in this study were identified as Halomonas pacifica M31 and Shewanella algae M69b using 16 rDNA sequences. Moreover, the total genome analysis of M31 and M69b validated the implication of bacterial genes in mixture dyes removal. Therefore, the effect of the selected bacterial consortium on ATE removal was confirmed and it may be used in industrial wastewater treatment to issuing environmental safety.


Assuntos
Ecossistema , Consórcios Microbianos , Consórcios Microbianos/genética , Corantes , Verde de Bromocresol , Sequenciamento Completo do Genoma
10.
Chaos ; 33(6)2023 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-37276578

RESUMO

We present an experimental technique to construct the response of nonlinear resonators under harmonic excitation as a control parameter is swept. Our technique can resolve nonlinear features in the resonator response, such as bifurcations and hysteresis. To validate it, we construct the frequency response of a MEMS resonator while the excitation frequency is swept. The response is measured optically and recorded in the time domain. The root-mean-square of the response is calculated over a variable-size time-window. The sweep time, window size, and frequency step size were found to be limited by the quality factor of the resonator under test. We examine and describe those limitations in terms of the slew rate and sampling frequency. Although we used optical measurements to validate the technique, the methods described herein are applicable to any measured response signal.

11.
Cureus ; 15(4): e37115, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-37153233

RESUMO

Background and Objectives Excessive video game use, particularly among young people, is a growing problem that poses potential serious mental health risks in many parts of the world. However, there is a lack of research on the prevalence of internet gaming disorder (IGD) in Saudi Arabia, particularly in Albaha region. The objective of this study was to determine the prevalence of IGD among a sample of intermediate and high school students in Albaha and to identify potential factors associated with the development of the disorder. Methods In this cross-sectional study, we collected data between August and November 2022 using a self-administered online Arabic questionnaire, which included a validated translation of the IGD-20 test, which is a tool based on the DSM-5 criteria for diagnosing IGD. We used a multistage sampling technique, with two administrative areas as clusters, to randomly select eight intermediate and high schools with an equal distribution of male and female students. We analyzed the data using descriptive statistics and chi-square analysis. Results A total of 391 participants were included in the study, with an age range of 12 to 18 years. Males accounted for 51.4% (n=201) of the sample, and females accounted for 48.6% (n=190). The prevalence of IGD was found to be 3.5% (n=14), with males accounting for 64% (n=9) of affected participants. The study found that prolonged gaming duration (three or more hours per day), using mobile phones for gaming, and engaging in online gaming were significant factors associated with the diagnosis of IGD (p<0.001, p<0.001, and p=0.004, respectively). Conclusion This study provides preliminary evidence on the prevalence of IGD among intermediate and high school students in Albaha, Saudi Arabia. The results suggest a lower incidence of IGD compared to studies conducted in other regions of the country. A larger study with in-person interviews is needed to confirm the findings and extend the generalizability of the results. Furthermore, the study highlights the need for further research to explore the risk factors associated with IGD and to develop interventions to address this emerging mental health issue among Saudi Arabian youth.

12.
Cureus ; 15(3): e35673, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-37012961

RESUMO

Introduction The COVID-19 pandemic has resulted in significant hospitalizations and deaths, particularly among healthcare workers (HCWs). Various therapeutic and preventive measures have been introduced, with vaccination considered the primary preventive measure. This study aims to assess the perceptions and acceptance of COVID-19 vaccination among HCWs. Methods We conducted an analytical cross-sectional study on HCWs in hospitals located in Jeddah, Saudi Arabia. The study included physicians, nurses, pharmacists, lab technicians, and radiologists who work in the Ministry of Health's general hospitals. A total of 394 participants were included in the study. Data were analyzed using SPSS v26, and a p-value less than 0.05 was considered significant. Results A majority of the participants (72.6%) were female, aged between 31-40 years (55.3%), and married (59.6%). More than half of the participants (55.6%) had received training on dealing with COVID-19. The mean scores for COVID-19 vaccine refusal, perceived susceptibility, perceived severity, perceived benefits, perceived barriers, and perceived effectiveness of COVID-19 vaccination were 18.36 ± 7.02, 14.48 ± 3.62, 11.51 ± 2.99, 12.39 ± 3.5, 8.25 ± 2.35, and 8.40 ± 2.46, respectively. Age was found to be correlated with the perceived severity of COVID-19 in non-vaccination (p=0.048), while gender was associated with the perceived severity of COVID-19 (p=0.015). Marital status (p=0.001), years of experience (p=0.009), profession (p=0.019), and education (p=0.028) were found to be correlated with perceived susceptibility. Education levels were found to be correlated with the perceived benefits of vaccination (p=0.007), perceived barriers to vaccines (p=0.002), and vaccine views (p=0.002). Years of experience (p=0.017) were found to be correlated with perceived severity of COVID-19, while profession type was significantly associated with perceived severity of COVID-19 (p=0.016) and vaccine view (p=0.008) Conclusion The study found that participants had a positive perception and high acceptance of COVID-19 vaccination. The results also indicated that various sociodemographic factors were associated with the perception and acceptance of COVID-19 vaccines among HCWs. These findings could help in formulating effective strategies to improve vaccination uptake rates among HCWs, thereby reducing transmission and mortality among Health Care Workers due to COVID-19.

13.
Cureus ; 15(12): e50296, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38205482

RESUMO

INTRODUCTION: The aim of this study was to evaluate the yield of bronchoscopy-guided bronchoalveolar lavage (BAL) and decisions on management of antimicrobials in critically ill patients with hematological malignancy and/or hematological stem cell transplant (HSCT). The safety and tolerance of bronchoscopy were also reported. METHODS: A retrospective cohort study was conducted by reviewing health charts of all adult patients with a hematological malignancy and/or an HSCT who were admitted to the intensive care unit and underwent bronchoscopy and BAL over four years from April 2016 to April 2020 at King Abdulaziz Medical City, Riyadh.  Results: The cohort included 75 critically ill patients. Of these 75 patients, 53 (70.7%) had HSCT (allogenic 66%, autologous 32.1%, haplogenic 3.8%). Computed tomography of the chest was abnormal in all patients. Predominant findings included airspace abnormalities, ground glass opacities, and others. The positive yield was found to be 20% for bacterial, 22% for viral, 21% for fungal, and other organisms were identified in 2%. Although cytology was not performed in 18 patients, malignant cells were identified on BAL in two patients. While the overall mortality of the cohort was high (46.7%), the vast majority (94.7%) tolerated bronchoscopy and BAL without any complications. However, three patients (4%) developed a pneumothorax and one patient bled and developed the acute respiratory distress syndrome post bronchoscopy. CONCLUSIONS: BAL can identify and detect microorganisms directly influencing the clinical care of patients who have received non-invasive diagnostic tests that yielded negative culture results. Bronchoscopy and BAL are generally safe and well tolerated by critically ill patients with hematological malignancy or HSCT.

14.
Acta Biomed ; 93(5): e2022245, 2022 10 26.
Artigo em Inglês | MEDLINE | ID: mdl-36300232

RESUMO

BACKGROUND AND AIM: Highly competitive and demanding environments in educational institutions led to reduced sleep time for both students and faculty globally. The primary objective of this study was to determine the duration and quality of sleep among students and faculty of Imam Abdulrahman Bin Faisal University (IAU). The secondary objective was to explore the relationship between depression and sleep duration and quality among students and faculty. METHODS: The study was conducted during 2021 in Dammam, Saudi Arabia. An online survey was disseminated among the university students. The survey form included: demographic data, Patient Health Questionnaire (PHQ9), Pittsburg Sleep Quality Index (PSQI) and Epworth Sleepiness scale (ESS). The responses were analyzed using bivariate and multivariate analysis. RESULTS: A total of 509 responses satisfying the inclusion criteria were included (323 student and 186 faculty). The average sleep duration for the entire cohort was 6.21 ± 1.32 hours, with 6.5% sleeping less than 5 hours per night. The mean PSQI score was 7.61 ± 3.09, with 73.1% falling in the poor sleep quality category (PSQI score >5). The mean PHQ9 score was 8.86 ± 6.20, with 63.9% falling in the  mild depression category. The mean ESS score was 6.59 ± 4.02, with 11% having a score >10 (corresponding to excessive daytime sleepiness). CONCLUSIONS: A significant proportion of surveyed students and faculty IAU suffer from sleep insufficiency, poor sleep quality, and mild degree of depression. Initiatives to tackle the issue of poor sleep quality and quantity among university students and faculty are required.


Assuntos
Depressão , Sono , Humanos , Universidades , Depressão/epidemiologia , Estudantes , Inquéritos e Questionários , Docentes
15.
Sensors (Basel) ; 22(11)2022 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-35684724

RESUMO

We report on the deployment of MEMS static bifurcation (DC) sensors for the detection of volatile organic compounds (VOCs): hydrogen sulfide and formaldehyde. We demonstrate a sensor that can detect as low as a few ppm of hydrogen sulfide. We also demonstrate a sensor array that can selectively detect formaldehyde in the presence of benzene, a closely related interferent. Toward that end, we investigate the sensitivity and selectivity of two detector polymers-polyaniline (PANI) and poly (2,5-dimethyl aniline) (P25DMA)-to both gases. A semiautomatic method is developed to functionalize individual sensors and sensor arrays with the detector polymers. We found that the sensor array can selectively sense 1 ppm of formaldehyde in the presence of benzene.


Assuntos
Sulfeto de Hidrogênio , Sistemas Microeletromecânicos , Compostos Orgânicos Voláteis , Benzeno , Formaldeído , Polímeros
16.
Cureus ; 14(4): e24001, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35547440

RESUMO

Background Asthma is a reactive airway disease that has a high prevalence across the globe. Asthma exacerbations can occur due to various bacterial and viral infections that irritate nerve endings in the airways. With time, airway obstruction follows, and patients with asthma have various symptoms that occur intermittently. Asthma symptoms primarily include breathlessness, wheezing, coughing, and chest tightness. This research focused on the association between the Asthma Control Test (ACT) score and number of exacerbations per year. Methods  A questionnaire-based, cross-sectional study was conducted at the outpatient pulmonary clinic, King Abdulaziz Medical City, a tertiary hospital in Riyadh. The study included 227 adult patients who were diagnosed with asthma and had no other pulmonary diseases or other medical diseases that could mimic asthma exacerbation. Data was collected by direct interview with the patients and through the BESTCare system in King Abdulaziz Medical City. All the data were collected through Microsoft Excel 2010 (Microsoft, Redmond, WA, USA) and analyzed using Statistical Package for Social Sciences (SPSS) Statistics version 23 (IBM Corp., Armonk, NY, US). The categorical data we used were presented by percentages and frequencies such as gender, whereas the numerical data were prescribed as mean and standard deviation such as age and number of exacerbations. For inferential statistics, Chi square was used to find the association between the categorical variable while T-test and ANOVA test were used to find the relationship between asthma control test score of asthmatic patients, which was divided into three different groups based on their scores that include: well-controlled, partially controlled, or uncontrolled, and the number of exacerbations per year.  Results A total of 227 adult asthma patients were enrolled in this study, most of them were females (72.7%). Average age of the participants was 47.3 ± 13.8 years. The average ACT score was found to be 18.5 ± 4.9 out of 25. Uncontrolled asthma was present in 26% of the patients, 22.9% were partially controlled and 51.1% had well-controlled asthma; to relieve the exacerbation most of the patients used salbutamol (51.5%), 35.2% used oxygen and 30.4% did not use any medication. Gender and age were not associated with ACT score (P = 0.787 and 0.797, respectively), whereas number of exacerbations was significantly associated with ACT score (P = 0.000), as fewer exacerbations were reported with higher ACT scores. Conclusion About one-quarter of the patients had uncontrolled asthma, slightly less than one-quarter of the patients had partially controlled asthma while more than half of the patients had well-controlled asthma. Number of exacerbations was found to be significantly associated with asthma control test score as fewer exacerbations were reported in well-controlled asthmatic patients.

18.
Sensors (Basel) ; 22(3)2022 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-35161449

RESUMO

In this paper, we presented a novel electrostatic Roll/Pitch MEMS gyroscope with in-plane drive mode and out-of-plane sense mode. The proposed structure is developed based on a tuning fork gyroscope with decoupled sense mass on each tine that control the sense out-of-plane frequency. A multi-height deep reactive ion etching (DRIE) fabrication process was utilized to achieve and enhance decoupling between the drive and sense modes. We presented our design methodology followed by an analytical and finite element (FEM) model. Our experimental results showed a good match between the analytical model and those obtained experimentally, from the drive and sense oscillation frequencies. Our characterization setup used a custom made application specific integrated circuit (ASIC) for characterization and was able to achieve ARW of 0.2 deg/rt-h, a bias instability 5.5 deg/h, and scale factor non-linearity (SFNL) 156 ppm FS.

19.
Cureus ; 13(11): e19623, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34926080

RESUMO

Pediatric convulsive seizure is common and represents a source of major concern and anxiety for the parents. Seizures can have a broad spectrum of etiologies in children, including metabolic, traumatic, developmental, and infectious causes. Depending on the clinical presentation, laboratory testing and neuroimaging may be indicated in the workup of the first unprovoked afebrile seizure. We present a case of a six-year-old boy who was brought to the emergency department by his mother after an episode of convulsion. She reported that he had jerky repetitive movements of all extremities that lasted around two minutes with spontaneous termination. The child did not have a febrile illness. The mother reported no history of similar episodes. Upon examination, the child appeared alert and conscious. No dysmorphic features were evident. Initial laboratory investigations were within the normal limits. The child underwent magnetic resonance imaging for the brain, which demonstrated a large well-defined extra-axial cystic lesion occupying most of the left hemisphere that is connected to the ventricular system. The lesion had no grey-matter lining and it strictly followed the cerebrospinal fluid in all sequences. Such finding represented the diagnosis of a giant left porencephalic cyst. Porencephaly is an extremely rare neurological anomaly that may present with pediatric seizures. Magnetic resonance imaging is the gold standard modality for the diagnosis of porencephaly. The case demonstrated that porencephaly can have a massive size in a patient with normal psychoneurological development.

20.
Biomater Sci ; 9(18): 6037-6051, 2021 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-34357362

RESUMO

Glioblastoma (GBM) is the most aggressive malignant brain tumor and is associated with a very poor prognosis. The standard treatment for newly diagnosed patients involves total tumor surgical resection (if possible), plus irradiation and adjuvant chemotherapy. Despite treatment, the prognosis is still poor, and the tumor often recurs within two centimeters of the original tumor. A promising approach to improving the efficacy of GBM therapeutics is to utilize biomaterials to deliver them locally at the tumor site. Local delivery to GBM offers several advantages over systemic administration, such as bypassing the blood-brain barrier and increasing the bioavailability of the therapeutic at the tumor site without causing systemic toxicity. Local delivery may also combat tumor recurrence by maintaining sufficient drug concentrations at and surrounding the original tumor area. Herein, we critically appraised the literature on local delivery systems based within the following categories: polymer-based implantable devices, polymeric injectable systems, and hydrogel drug delivery systems. We also discussed the negative effect of hypoxia on treatment strategies and how one might utilize local implantation of oxygen-generating biomaterials as an adjuvant to enhance current therapeutic strategies.


Assuntos
Neoplasias Encefálicas , Glioblastoma , Materiais Biocompatíveis/uso terapêutico , Barreira Hematoencefálica , Neoplasias Encefálicas/tratamento farmacológico , Sistemas de Liberação de Medicamentos , Glioblastoma/tratamento farmacológico , Humanos
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