RESUMO
This article reviews the recent dermatopathology literature regarding cutaneous adnexal neoplasms, with emphasis on new and underrecognized entities, "old entities" with new findings, advances in immunohistochemistry, and new findings in relation to inherited disorders associated with cutaneous adnexal neoplasms.
Assuntos
Neoplasias de Anexos e de Apêndices Cutâneos/patologia , Síndromes Neoplásicas Hereditárias/patologia , Biomarcadores Tumorais/análise , Biomarcadores Tumorais/genética , Biópsia , Dermatologia/métodos , Predisposição Genética para Doença , Humanos , Imuno-Histoquímica , Neoplasias de Anexos e de Apêndices Cutâneos/química , Neoplasias de Anexos e de Apêndices Cutâneos/genética , Síndromes Neoplásicas Hereditárias/genética , Síndromes Neoplásicas Hereditárias/metabolismo , Patologia/métodos , Fenótipo , Valor Preditivo dos Testes , PrognósticoRESUMO
The "acid mantle" is a topic not only of historical interest, but also of clinical significance and has recently been linked to vital stratum corneum function. Despite compelling basic science evidence placing skin pH as a key factor in barrier homeostasis, stratum corneum integrity, and antimicrobial defense, application of the acid mantle concept in clinical care is lacking. We review recent basic science investigations into skin pH, discuss skin disorders characterized by aberrant pH, and finally discuss practical application for preservation of the acid mantle. Recognizing factors that alter skin pH and selecting products that preserve the acid mantle is of prime importance in treating dermatologic patients.
Assuntos
Higiene da Pele , Dermatopatias/metabolismo , Pele/metabolismo , Pesquisa Translacional Biomédica , Animais , Homeostase , Humanos , Concentração de Íons de Hidrogênio , Pele/patologia , Higiene da Pele/métodos , Dermatopatias/patologiaAssuntos
Dermatite Atópica/patologia , Orelha Externa/patologia , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Adulto JovemRESUMO
BACKGROUND: Sarcoidosis is a systemic disease that may present as tattoo granulomas. OBJECTIVE: A patient with systemic sarcoidosis who developed a granulomatous reaction within a tattoo is presented to stimulate interest in this unusual phenomenon. METHODS AND RESULTS: A patient with a 6-year history of pulmonary sarcoidosis developed sarcoidal granulomas restricted to one pigment of a tattoo. Previous reports of sarcoidal granulomas within tattoos are reviewed, and information about the pathogenesis of this process is explored. CONCLUSION: Sarcoid granulomas may develop in tattoos as an isolated local reaction or as the presenting sign of systemic sarcoidosis. The reaction itself may provide insight into further understanding the pathogenesis of sarcoidosis.
Assuntos
Sarcoidose/diagnóstico , Sarcoidose/etiologia , Dermatopatias/diagnóstico , Dermatopatias/etiologia , Tatuagem/efeitos adversos , Abdome , Adulto , Corantes/efeitos adversos , Diagnóstico Diferencial , Feminino , Humanos , Sarcoidose/patologia , Dermatopatias/patologiaRESUMO
In a linguistically diverse society, healthcare professionals must overcome the daunting task of effectively communicating with patients who speak a different language. In effort to aid healthcare professionals and their patients, an on-line dermatology patient education resource was created with links to various skin related topics in over 30 languages. The development of the on-line resource, key features of the information available on the website, and limitations experienced during its creation are discussed in the article.
