Recent Advancement of the Current Aspects of g-C3 N4 for its Photocatalytic Applications in Sustainable Energy System.

Being one of the foremost enticing and intriguing innovations, heterogeneous photocatalysis has also been used to effectively gather, transform, and conserve sustainable sun's radiation for the production of efficient and clean fossil energy as well as a wide range of ecological implications. The generation of solar fuel-based water splitting and CO2 photoreduction is excellent for generating alternative resources and reducing global warming. Developing an inexpensive photocatalyst can effectively split water into hydrogen (H2 ), oxygen (O2 ) sources, and carbon dioxide (CO2 ) into fuel sources, which is a crucial problem in photocatalysis. The metal-free g-C3 N4 photocatalyst has a high solar fuel generation potential. This review covers the most recent advancements in g-C3 N4 preparation, including innovative design concepts and new synthesis methods, and novel ideas for expanding the light absorption of pure g-C3 N4 for photocatalytic application. Similarly, the main issue concerning research and prospects in photocatalysts based g-C3 N4 was also discussed. The current dissertation provides an overview of comprehensive understanding of the exploitation of the extraordinary systemic and characteristics, as well as the fabrication processes and uses of g-C3 N4 .

Design and synthesis of adamantane-1-carbonyl thiourea derivatives as potent and selective inhibitors of h-P2X4 and h-P2X7 receptors: An Emerging therapeutic tool for treatment of inflammation and neurological disorders.

P2X receptors are potential therapeutic targets for the treatment of various neurodegenerative disorders, pain, inflammation, hypertension, and cancer. Adamantane ring has been reported to exhibit significant inhibitory potential towards P2X receptors, especially for P2X7R. We have utilized uniqueness of adamantane moiety in our synthesized compounds and introduced various substitutions that enhanced the potency as well as selectivity for P2XR subtypes. Among synthesized derivatives, 4n and 5b were found to be most potent and selective inhibitors for h-P2X4R and h-P2X7R, respectively. 4n was found to be highly selective for h-P2X4R with IC50 ± SEM = 0.04 ± 0.01 µM, that is 22 times more potent than BX-430, a standard selective inhibitor of h-P2X4R. 5b has IC50 ± SEM of 0.073 ± 0.04 µM, which is comparable with the known antagonists of h-P2X7R. 4n and 5b were studied for mode of inhibition of P2XRs and both were found to be negative allosteric modulators. In silico studies were also conducted to find the type of interactions as well as mode of inhibition.

Knowledge rather than language proficiency affects achievement scores in interactive objectively structured performance evaluation.

BACKGROUND: A common belief is that language proficiency might have affected the outcome scores of the Oral Structured Performance Evaluation (OSPE) especially at the interactive stations. The objective of this study was to explore this postulation. METHODS: The subject of Behavioural Sciences was examined for the first time as a component of undergraduate medical curriculum in 2nd Professional Medical Examinations in 2007. Equal weightage was given to written and OSPE components in the examination. The OSPE scores in the interactive component of all (1457) candidates were compared with their written scores in the subject of Behavioural Sciences as well as their Higher Secondary School Certificate (HSSC) scores in the subject of English using Multiple Linear Regression Analysis in SPSS v.12. RESULTS: Overall as well as in the Public Medical Colleges, relative to each other, knowledge of the subject as indicated by marks obtained in the written component of the examination exerted a positive and statistically significant (p < 0.05), and command over language as indicated by marks obtained in the HSSC examination exerted a small positive but statistically insignificant (p = 0.231 and 0.639 respectively) influence on the performance of students in the interactive OSPE component. In the private medical colleges command over language exerted a small negative but statistically insignificant (p = 0.936) influence on the performance of students in the interactive OSPE component of the examination. CONCLUSION: Command over the subject content is the best indicator of achievement in OSPE.