[Neuroendocrine system function in early hypogalactia]. / Sostoianie neiroéndokrinnoi sistemy pri rannei gipogalaktii.

A study was made of the state of the hypophyseogonadal, hypophyseoadrenocortical, hypophyseothyroid systems and the level of regulatory neuromediators in puerperae with a different intensity of lactation. Early hypogalactia was shown to be a neuroendocrine pathology affecting the central links of regulation of lactation as well as function of the peripheral endocrine glands.

[Use of tryptophan and thyroidin for complex correction of hormonal disorders in experimental hypogalactia in rats]. / Ispol'zovanie triptofana i tireoidina v kachestve kompleksnoi korrektsii gormonal'nykh narushenii pri éksperimental'noi gipogalaktii krys.

The interlinked functioning of the hypothalamo-hypophyseo-breast and hypothalamo-hypophyseo-thyroid systems in experimental hypogalactia (electric stimulation) as well as a possibility of effective correction of neuroendocrine disorders of lactation were studied using tryptophan in combination with microdoses of thyroidin. The hypothalamic and blood concentrations of monoamines (MA) were determined by fluorometry (spectrofluorometers SFM-22, Contron, Switzerland), the blood levels of hormones were determined by a radioimmunoassay. The effect of chronic stress on the monoaminergic hypothalamic system was shown to be based on an increase in the catecholaminergic tone and suppression of serotoninergic tone. It resulted in the suppression of the synthesis and secretion of prolactin, STH, in an elevated blood level of TSH and a considerable reduction of the level of thyroid hormones. The result was weakened secretory function of the breast. Tryptophan and thyroidin administration to rats, subjected to stress, returned to normal function. The investigation brought to light the idea of pathogenesis of hypogalactia, resulting in a new approach to therapy of this pathological condition.

[The stimulation of prolactin secretion by the simultaneous inhibition of the dopaminergic and activation of the serotoninergic systems in the hypothalamus]. / Stimuliatsiia sekretsii prolaktina odnovremennoi ingibitsiei dofaminergicheskoi i aktivatsiei serotoninergicheskoi sistem gipotalamusa.

Lactotropic adenohypophyseal function and lactation intensity were studied under simultaneous blockade of dopamine receptors and stimulation of serotonin metabolism in the rat hypothalamus. Blockade of hypothalamic dopamine receptors by tricedil decreased the dopamine level, increased the serotonin content and intensified its metabolism thus increasing the prolactin secretion. Under these conditions, tryptophan application potentiated the above changes in hypothalamic catecholamine and indolamine metabolism, increased the prolactin secretion. The latter is associated with the brain serotoninergic system reactivity to suckling impulses: an important factor in the lactation reflex. Tryptophan maintains a high level of hypothalamic serotonin metabolism, maintaining an increase in the prolactin secretion level and secretory activity of the mammary glands.

[Effect of chronic stress during pregnancy on the thyroid status of mother and progeny]. / Vliianie khronicheskogo stressa v period beremennosti na tireoidnyi statusa materi i potomstva.

The effect of chronic stress (electric stimulation) in the second half-period of pregnancy on the status of the hypophyseothyroid system of mother and her progeny was studied. Experiments were staged on 100 pregnant rats and their progeny aged 20 days, 1, 2, 3 and 6 mos. The content of thyroxine (T4), triiodothyronine (T3) and thyrotropic hormone (TTH) in the blood of mother (in the midterm and at the end of pregnancy) and progeny was determined by a radioimmunoassay. Chronic stress during pregnancy led to a decrease in the level of thyroid hormones by the end of pregnancy, the decrease being more significant than that in controls. In the progeny of experimental rats higher T4 content (as compared to that in controls) was accompanied by a lowered level of T3 indicating a decrease in the metabolism of thyroid hormones. These changes were most noticeable at early stages of development but were preserved till puberty. Thus chronic stress during pregnancy led to a decrease in the content of thyroid hormones in the mother's blood, an increase in thyroid function of progeny, and a decrease in its general thyroid status.

[Simulation of thymus hypo- and hyperplasia by thymalin in guinea pigs]. / Modelirovanie gipo- i giperplazii timusa s pomoshch'iu timalina u morskikh svinok.

Potentialities of the modulation of thymus function with thymalin and the hormonal-immunological status in simulated hypo- and hyperplasia of the thymus. The advisability of the use of the drug was shown.

[Effect of chronic stress during pregnancy on the functional state of the hypothalamo-hypophyseo-adrenal system in the progeny]. / Vliianie khronicheskogo stressa vo vremia beremennosti na funktsional'noe sostoianie gipotalamo-gipofizarno-nadpochechnikovoi sistemy u potomstva.

A study was made of the effect of a chronic stress on the activity of the hypothalamo-hypophyseo-adrenal system in pregnant rats as well as on the development of its function in the progeny in postnatal ontogenesis. Experiments were made on pregnant Wistar rats and their progeny. A chronic stress in the 2nd half of pregnancy has been shown to have a detrimental effect on function of the hypothalamo-hypophyseo-adrenal system not only of pregnant animals but also of their progeny, particularly in early periods of postnatal development. In prenatally stressed animals a delay in the development of the monoaminergic system of the hypothalamus was observed which, in its turn, had an effect on the level of the main adenohypophyseal hormones (ACTH, STH and prolactin).

[Secretion of somatotropic hormone in patients with pancreatitis]. / Sekretsiia somatotropnogo gormona u bol'nykh pankreatitami.

The concentration of somatotropic hormone (STH) was measured by radioimmunoassay in 108 patients with acute and chronic pancreatitis and in 15 healthy persons. In addition, to study the reserve capacity of the somatotropic function of the pituitary, insulin hypoglycemia was employed. It was established that during exacerbation, the pancreatitis patients manifested an increase in the hormone content. In the patients suffering from acute pancreatitis, the STH level returned to normal following treatment. In chronic pancreatitis, the hormone concentration remained elevated after treatment. No correlation was discovered between alterations in the STH level and the activity of pancreatic enzymes. The data obtained point to a definite role of STH in the pathogenesis of chronic pancreatitis.

[Hyperplasia of the thymus gland in children: physiology or pathology?]. / Giperplaziia vilochkovoi zhelezy u detei--fiziologiia ili patologiia?

A critical analysis of the literature data and of the results of clinicoroentgenological, hormonal and immunological studies in children with thymomegaly makes it possible to regard hyperplasia of the thymus gland at early childhood as a sign of functional incompetence of the thymus and of the secondary immunodeficient state.