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1.
Anal Biochem ; 657: 114873, 2022 11 15.
Artigo em Inglês | MEDLINE | ID: mdl-36108794

RESUMO

Ammonia is one of the main players in the pathogenesis of hepatic encephalopathy (HE) in patients with chronic liver diseases. The usefulness of measuring ammonemia has been debated since many years. New data reveal that besides helping in the differential diagnosis of HE, ammonemia could be a prognostic marker not only in patients with HE, but also in patients without any neurological symptoms, suggesting a potential toxic role of ammonia beyond the brain. Finally, targeting ammonemia while monitoring therapeutic response could be a way to improve outcomes in patients with HE.


Assuntos
Amônia , Encefalopatia Hepática , Encéfalo , Diagnóstico Diferencial , Encefalopatia Hepática/diagnóstico , Encefalopatia Hepática/etiologia , Humanos , Cirrose Hepática
2.
Anal Biochem ; 636: 114477, 2022 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-34808106

RESUMO

Metabolomics refers to the study of biological components below 1000 Daltons (Da) involved in metabolic pathways as substrates, products or effectors. According to the interconnected metabolic disturbances that have been described in the pathophysiology of hepatic encephalopathy (HE), this technique appears to be well adapted to study and better delineate the disease. This review will focus on recent advances in metabolomics in the field of HE. Thus, after a brief overview of the general principles of metabolomics, we will discuss metabolomics as a potentially efficient tool for unraveling new HE pathophysiological insights, biomarkers identification, or as a predicting tool for treatment response or outcome prognosis. Finally, we will give our vision on the prospects offered by metabolomics for improving care of HE patients.


Assuntos
Encefalopatia Hepática/metabolismo , Encefalopatia Hepática/terapia , Redes e Vias Metabólicas , Metabolômica , Biomarcadores/metabolismo , Humanos , Prognóstico
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