Basidiobolomycosis Mimicking Fistulizing Crohn's Disease: A Case Report From Saudi Arabia.

Gastrointestinal basidiobolomycosis (GIB) is a rare, emerging fungal infection caused by Basidiobolus ranarum, which requires a high index of clinical suspicion for early diagnosis and management. It is prevalent in hot and humid regions, and its clinical manifestations may mimic inflammatory bowel disease (IBD), malignancy, and tuberculosis (TB). This often results in the disease being missed or incorrectly diagnosed. We present the case of a 58-year-old female patient from the southern region of Saudi Arabia who presented with persistent non-bloody diarrhea for four weeks and was found to have GIB. This condition is associated with significant morbidity and mortality if not diagnosed and treated in a timely manner. The optimal therapeutic strategy for managing this rare infection has not yet been established. Most patients described in the literature have received a combination of pharmaceutical and surgical therapy. Including GIB in the differential diagnosis of gastrointestinal disorders that do not fit the diagnosis may help with its early diagnosis and management.

Unmasking the Deadly Fungus: A Case Report of Rhino-Orbital-Cerebral Mucormycosis in a Diabetic Patient With Unusual Presentation.

Mucormycosis (zygomycosis) is a rare, rapidly progressive fungal infection that is opportunistic and usually affects immunocompromised individuals, most commonly patients with diabetes mellitus. It is a fatal infection that requires high clinical suspicion and early disease identification. The global burden of mucormycosis is unknown as it is a rare disease. However, the burden of mucormycosis is increasing worldwide, with the emergence of new risk factors and causative agents. In the Saudi population, the discovered cases and the overall prevalence were low. Herein, we present a case of mucormycosis infection aiming to illustrate the clinical characteristics and the management strategy, besides adding another case to the literature.

Cytomegalovirus Colitis in a Patient With Ulcerative Colitis on Vedolizumab Monotherapy.

Cytomegalovirus (CMV) is a human herpes-type virus with variable clinical manifestations. Infections in immunocompetent patients are usually asymptomatic or mild, and severe infections are generally seen in immunosuppressed individuals. CMV colitis is not uncommon in patients with ulcerative colitis (UC) and is mostly associated with the use of steroids, immunomodulators like azathioprine, and biologics like infliximab, which have systemic immunosuppressive effects. Vedolizumab is an anti-integrin antibody that is gut-selective without any systemic effects. We report an unusual presentation of a female patient with UC who had concomitant CMV colitis and erythema nodosum, who was on vedolizumab, and not on any steroids or other immunosuppressants. She responded well to anti-viral treatment and steroids.