Clinical and immunological evaluation of peri-implant tissues around ultra-polished and conventionally-polished zirconia abutments. A 1-year follow-up randomized clinical trial.

PURPOSE: This is a randomized clinical trial to compare the clinical and immunological performance of ultrasmooth versus conventionally-smooth zirconia abutments placed subgingivally after a period of 1 year. MATERIALS AND METHODS: Sixty-two bone level platform-switched implants (NobelParallel CC) were placed epicrestally in the mandibular molar or premolar region in 62 patients. After osseointegration, implants were restored with auto polymerizing acrylic resin crowns and subsequently randomly allocated to two groups according to the type of screw-retained zirconia crown prescribed. The control group received custom zirconia restoration with the subgingival zirconia part conventionally polished, whereas the test group implants were restored with ultra-polished zirconia abutments. Periodontal parameters (PD, PI, and BOP) and marginal bone level changes (MBLC) were recorded for each implant 2 months after insertion (T0), 1 month after final delivery of the crown (T2), and at the 1-year follow-up (T3). Immunological mediators from gingival crevicular fluid (IL-1α, IL-1ra, and TNF-α) were inspected at 1 month after provisional (T1) and accordingly at T2 and T3. Data was analyzed statistically, and significance level was set to α = 0.05. RESULTS: After 1 year, there were no significant changes in PD control-2.18 ± 0.89 mm and test-2.5 ± 0.72 mm (p = 0.073). PD between T2 and T3 dropped significantly in the test group (p = 0.037) and remained stable in the control group. PI was not different in both groups at T0 (p = 0.518) and T2 (p = 0.817). At T3, the test group (0.9 ± 1.01) had a significantly lower PI than the control group (1.55 ± 1.23) (p = 0.035). There was no difference in BOP positive cases between groups after 1 year (control-61.3%, test-51.7%, and p = 0.455). The amount of IL-1ra decreased significantly in the test group (41.75 ± 57.58) (p = 0.001) but not in the control group (59.59 ± 70.43) (p = 0.177). MBLC for the control and test groups after 1 year were 0.68 ± 0.7 and 0.94 ± 0.65 mm (p = 0.061). CONCLUSIONS: PD dynamics, PI, BOP, and IL-1ra revealed better outcomes around ultra-polished zirconia abutments than around conventionally polished zirconia abutments.

Efficacy of Proanthocyanidins in Nonsurgical Periodontal Therapy.

BACKGROUND: The aim of this work was to evaluate the efficacy of proanthocyanidins (PACNs) as an adjunctive periodontal therapy in patients with periodontitis. METHODS: Patients with periodontitis (stage III-IV) were included in this randomised clinical study. Patients with periodontitis received 2 different treatment modalities: minimally invasive nonsurgical therapy only (MINST group) or minimally invasive nonsurgical therapy and subgingival application of collagen hydrogels with PACNs (MINST + PACNs group). Clinical periodontal parameters, that is, pocket probing depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), plaque index (PI), were evaluated before treatment and after 8 weeks. Concentrations of immunologic markers, matrix metalloproteinase-3 (MMP-3), and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in saliva were assessed at baseline and at 8-week follow-up. RESULTS: Forty-six patients diagnosed with periodontitis were randomised into 2 groups: 23 patients in the MINST group and 23 patients in the MINST + PACNs group received the intended treatment. PACNs combined with MINST resulted in additional statistically significant PPD reduction and CAL gain in moderate periodontal pockets by 0.5 mm (P < .05) on average compared to MINST alone. Additional use of PACNs did not result in additional statistically significant improvement of BOP or PI values. Application of PACNs showed significant reduction of MMP-3 levels in saliva after 8 weeks (P < .05). CONCLUSIONS: Adjunctive use of PACNs in MINST resulted in better clinical outcomes for moderate pockets. Additional use of PACNs improved MMP-3 concentration in saliva more than MINST alone. Biochemical analysis revealed that MMP-3 concentration in saliva reflected the periodontal health state.