[The role of transaminases and mitochondrial anion porters in the energetics of animals of different ages]. / Rol' transaminaz i anionperenoschikov mitokhondrii v énergetike zhivotnykh raznogo vozrasta.

Aminohydroxyacetate, an inhibitor of aminotransferases, decreases the rate of oxygen consumption by 1-day-old young rats by 35% 10 min after intraperitoneal injection, whereas for 20-day-old rats, the inhibitory effect is 56%, and for adult mice, it is 83%. More prolonged exposure to aminohydroxyacetate leads to death of the animal. One-day-old rats die 90 min after the injection, 20-day-old rats die 30 min after the injection, and adult mice die 15 min after the injection. Butylmalonate (an inhibitor of mitochondrial dicarboxylate translocator) decreases the rate of energy metabolism to a lower extent, by 38% in adult mice and by 18% in 1-day-old rats. The animals generally remain alive after the exposure to this compound. 1,2,3-benzyltricarboxylate, an inhibitor of tricarboxylate transport, shows only a weak effect on energy metabolism of animals of any age. These results provide evidence that the role of the transaminase system in energy metabolism increases with age. Mechanisms underlying weak sensitivity of newborn animals to these inhibitors are discussed.

[The lipolytic enzyme activity of the mitochondrial membranes of the digestive organs in heat stress in rats]. / Aktivnost' lipoliticheskikh fermentov membran mitokhondrii pishchevaritel'nykh organov pri teplovykh stressakh krys.

An augmentation of catalytic activity of phospholipase A and lysophospholipase A occurred in the liver mitochondria membranes and small intestine mucosa in rats subjected to heat. The augmentation of the latter's activity was significantly lesser in overheated rats.