RESUMO
The potential protective effect of selenium status on the risk of developing cancer has been examined in animal and epidemiologic studies. This ecological study investigated the association between U.S. county forage selenium status and site- and sex-specific county cancer mortality rates (1950-1969) using weighted least squares regression. Consistent, significant (p less than .01) inverse associations were observed for cancers of the lung, rectum, bladder, esophagus, and cervix in a model limited to rural counties and for cancers of the lung, breast, rectum, bladder, esophagus, and corpus uteri in a model of all counties. No consistent significant positive associations were observed in the rural county models. This remarkable degree of consistency for the inverse associations strengthens the likelihood of a causal relationship between low selenium status and an increased risk of cancer mortality.
Assuntos
Agricultura , Neoplasias/mortalidade , Selênio/deficiência , Ecologia , Feminino , Humanos , Masculino , Neoplasias/etiologia , Análise de Regressão , Saúde da População Rural , Estados UnidosAssuntos
Inositol/farmacologia , Sementes/metabolismo , Verduras , Zinco/metabolismo , Absorção , Fenômenos Fisiológicos da Nutrição Animal , Animais , Cálcio/metabolismo , Deficiências Nutricionais/metabolismo , Relação Dose-Resposta a Droga , Fertilizantes , Temperatura Alta , Inositol/metabolismo , Masculino , Plantas Comestíveis/metabolismo , Radioisótopos , Ratos , Sementes/crescimento & desenvolvimento , Sementes/fisiologia , Sulfatos/metabolismo , Zinco/administração & dosagem , Isótopos de ZincoRESUMO
Chromium was not required for normal growth of romaine lettuce (Lactuca sativa L. subsp. longifolia), tomato (Lycopersicon esculentum Mill.), wheat (Triticum aestivum L.), or bean (Phaseolus vulgaris L.) in solution culture containing 3.8 x 10(-4) muM Cr. Plants grown on this purified nutrient solution contained an average of 22 ng Cr/g dry weight. Duckweed (Lemna sp.) grew and reproduced normally on a dilute nutrient solution containing 3.8 x 10(-5) muM Cr.