1.
Klin Monbl Augenheilkd
; 198(5): 419-24, 1991 May.
Artigo
em Francês
| MEDLINE
| ID: mdl-1886375
RESUMO
Activity and phenotype of red blood cell esterase D were systematically determined in a population of 128 retinoblastoma patients from 99 families and compared to 158 controls, in order to detect a chromosome 13q14 deletion. Among these patients 12 were healthy carriers and 116 affected carriers of a mutant allele of the retinoblastoma susceptibility gene (110 retinoblastoma, 5 retinoma, 1 phtisis bulbi). 4 patients were found to have decreased ESD levels in connection with 13q14 deletion which was confirmed by chromosome analysis. The data presented here suggest that ESD quantification has a high specificity and sensitivity for the detection of homogenous chromosome 13 deletions in retinoblastoma patients.
Assuntos
Carboxilesterase , Hidrolases de Éster Carboxílico/genética , Deleção Cromossômica , Cromossomos Humanos Par 13 , Neoplasias Oculares/genética , Triagem de Portadores Genéticos , Retinoblastoma/genética , Neoplasias Oculares/diagnóstico , Feminino , Frequência do Gene/genética , Testes Genéticos , Humanos , Masculino , Fenótipo , Retinoblastoma/diagnóstico , Suíça
2.
FEBS Lett
; 113(2): 225-30, 1980 May 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6248360