[Regression of retroperitoneal fibrosis by combination therapy with tamoxifen and steroids]. / Rückbildung der Retroperitonealfibrose durch eine Kombinationstherapie von Tamoxifen und Steroiden.

BACKGROUND: Idiopathic retroperitoneal fibrosis is characterised by proliferation and fibrosis of retroperitoneal tissue. It is complicated by obstruction and encasement of retroperitoneal structures. CASE REPORT: We describe two female patients with idiopathic retroperitoneal fibrosis. Both had to undergo lateralization of the ureter because of ureteral obstruction. Also both patients developed thrombosis of the inferior vena cava resp. the common iliac vein. Because of the eventful course of the disease a combined tamoxifen and steroid therapy was started. Hereafter there was a marked regression of the retroperitoneal fibrotic masses and the previous inflammatory signs disappeared. CONCLUSION: Tamoxifen seems to be effective in the treatment of idiopathic retroperitoneal fibrosis by inducing a regression of the fibrotic masses. Especially in patients with continuous activity of the disease we recommend an additional steroid therapy to prevent a regeneration of the fibrosis.

[Hematuria--diagnostic procedure and therapeutic approaches]. / Die Hämaturie--Diagnostisches Vorgehen und therapeutische Ansätze.

Hematuria is a common clinical problem. It may arise from benign diseases posing minimal risk to the patient to potentially life-threatening conditions. Due to its many causes, the evaluation of hematuria often requires various different diagnostic procedures. To prevent unnecessary diagnostic tests, the workup should begin with noninvasive techniques such as history, urinalysis, laboratory data and ultrasonography. This proceeding allows a simple and rapid differentiation in renal and non-renal causes of hematuria in most cases.