Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Cell Transplant ; 12(6): 555-61, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-14579923

RESUMO

Bone marrow is the residence site of mesenchymal stem cells (MSC), which upon commitment and maturation develop into several mesenchymal phenotypes. Recently, we have described the presence of MSC in human cord blood (cbMSC) and informed that their properties are the same as those for MSC obtained from adult bone marrow. In this study we have investigated the capability of transplanted cbMSC to home and survive in the marrow of unconditioned nude mice. cbMSC utilized for transplantation studies were characterized by morphology, differentiation potential, and immunophenotype. After transplantation by systemic infusion, human DNA (as detected by PCR amplification of human-specific beta-globin gene) was detected in the marrow of recipients as well as in ex vivo-expanded stromal cells prepared from the marrow of transplanted animals. These results demonstrate homing and survival of cbMSC into the recipient marrow and also suggest a mesenchymal-orientated fate of engrafted cells, because human DNA was also detected in cells of other recipient tissues, like cardiac muscle, teeth, and spleen.


Assuntos
Medula Óssea/cirurgia , Transplante de Células-Tronco de Sangue do Cordão Umbilical/métodos , Sangue Fetal/citologia , Sobrevivência de Enxerto/imunologia , Síndromes de Imunodeficiência/terapia , Transplante de Células-Tronco Mesenquimais/métodos , Animais , Medula Óssea/imunologia , Diferenciação Celular/imunologia , Linhagem da Célula/imunologia , Tamanho Celular/imunologia , Quimiotaxia/imunologia , Transplante de Células-Tronco de Sangue do Cordão Umbilical/tendências , DNA/metabolismo , Modelos Animais de Doenças , Feminino , Globinas/genética , Humanos , Síndromes de Imunodeficiência/imunologia , Imunofenotipagem , Recém-Nascido , Transplante de Células-Tronco Mesenquimais/tendências , Camundongos , Camundongos Nus , Células Estromais/citologia , Células Estromais/imunologia , Transplante Heterólogo
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...