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1.
West J Nurs Res ; 41(11): 1602-1622, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-30616442

RESUMO

Sedentary lifestyles and obesity are known risk factors for breast cancer. Elevated estrogen levels correlate with obesity and, independently, with increased breast cancer risk. Lifestyle interventions that reduce obesity may mitigate this risk, potentially via estrogen pathways. In a 6-month lifestyle intervention, overweight/obese women with high breast cancer risk were randomized to control (n = 7) or intervention (n = 6) and analyzed for sex hormone levels. Serum and urine hormones were evaluated by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and sex hormone binding globulin (SHBG) by enzyme-linked immunosorbent assay (ELISA). Serum estrone (E1) and estradiol (E2) were reduced by 12.1% and 50.8%, respectively, at 9 months in the intervention group, which differed from controls (p = .043 and .020). This contrasted with a 73.3% increase in urine E1 at 6 months in the intervention group (p = .035). These results suggest that a lifestyle intervention led to a favorable estrogen profile in relation to breast cancer risk.


Assuntos
Neoplasias da Mama/metabolismo , Hormônios Esteroides Gonadais/metabolismo , Redução de Peso , Idoso , Neoplasias da Mama/epidemiologia , Feminino , Hormônios Esteroides Gonadais/sangue , Hormônios Esteroides Gonadais/urina , Humanos , Estilo de Vida , Pessoa de Meia-Idade , Obesidade/terapia , Sobrepeso/terapia , Projetos Piloto , Fatores de Risco
2.
West J Nurs Res ; 40(7): 976-996, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-28335697

RESUMO

One fourth of breast cancer can be attributed to sedentary lifestyles and being overweight or obese. This pilot study was conducted to explore whether a 6-month lifestyle intervention affected body composition and obesity-related biomarkers among women at high risk of breast cancer. Overweight/obese women at high risk of breast cancer were randomized to the control group or to the intervention. The intervention was an individually tailored, cognitive-behavioral therapy program that assists women in identifying strategies to improve their nutrition and physical activity habits with the goal of reduced adiposity. We compared changes in body composition and plasma biomarkers from baseline to 6 months. Body weight, adiposity, leptin, insulin resistance, and C-reactive protein were significantly reduced in the intervention group versus controls. No significant differences were observed in adiponectin, insulin, glucose, or interleukin-6. Our findings suggest that this intervention improves the metabolic and inflammatory profiles of overweight/obese women at risk of breast cancer.


Assuntos
Neoplasias da Mama/prevenção & controle , Terapia Cognitivo-Comportamental , Exercício Físico , Obesidade/terapia , Comportamento Sedentário , Adulto , Idoso , Composição Corporal , Feminino , Humanos , Pessoa de Meia-Idade , Fatores de Risco , Inquéritos e Questionários
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