The impact of confinement on older Jordanian adults' mental distress during the COVID-19 pandemic: A web-based cross-sectional study.

PURPOSE: This study aimed to determine the impact of Coronavirus disease, 2019 (COVID-19) confinement on older Jordanian adults' mental distress and to assess which study variables that predict Posttraumatic Stress disorder. DESIGN AND METHODS: This cross-sectional study was conducted on 315 older Jordanian adults using an online survey in Amman, Jordan between May 28 and June 12. FINDINGS: The assessment revealed a moderate level of avoidance (M = 1.97, SD = 0.7), a higher effect of intrusion (M = 2.08, SD = 0.9), an above midpoint level of fear 18.50 ± 8.6, and mild depression (M = 6.96, SD = 7.3). Hierarchical Multiple Regression model revealed that 77.8% of the Impact of Event Scale-Revised was explained by both Fear of COVID-19 Scale and Patient Health Questionnaire-9 (R change = 0.66, SE = 8.4, p < 0.001). PRACTICE IMPLICATION: This suggests that confinement affects different aspects of the psychological well-being of older Jordanian adults. An early assessment and intervention can make confinement as tolerable as possible.

Inflammatory Markers, Metabolic Profile, and Psychoneurological Symptoms in Women with Breast Cancer: A Literature Review.

Breast cancer is one of the most prevalent cancers in women. The improvement in breast cancer treatment has significantly increased the proportion of survival rate for women with breast cancer. Despite the advancement in breast cancer treatment, a great proportion of survivors suffer from co-occurring psychoneurological symptoms which impact their quality of life. The most frequently reported psychoneurological symptoms among women with breast cancer are depressive symptoms, anxiety, fatigue, sleep disturbances, and pain. These symptoms usually appear as a cluster. Inflammatory activation and serum metabolic alterations have been associated with the etiology of cancer and with various chronic neurocognitive disorders. However, to date, no studies considered the combined effects of inflammatory markers and metabolites in the development of psychoneurological symptoms in women with breast cancer especially those who were treated with chemotherapy. Further clarification of the relationships between the inflammatory markers, serum metabolic alterations, and psychoneurological symptoms in women with breast cancer should be pursued.