Comparative values of erythrocyte aggregability versus other indices of hemorheological disorders in patients with ischemic brain infarcts.

The aim of the present study is comparison of changes of principal hemorheological factors responsible for blood flow disorders in the microcirculation in patients with ischemic brain infarcts. It was found that in venous blood samples the erythrocyte aggregability (examined with a direct, highly sensitive, quantitative technique) was considerably more increased (by mean of 120%) than the blood plasma fibrinogen contents, blood plasma viscosity, and hematocrit which increased only by 23.7%, 7.4% and 3.6%, respectively, as compared to the same hemorheological factors in the healthy controls. These results led us to the following conclusion: among the other tests the enhanced erythrocyte aggregability, when measured with an appropriate technique, is the best diagnostic indicator of hemorheological derangements during development of the ischemic brain infarct.

[Morphologic criteria of the thrombohemorrhagic syndrome in acute craniocerebral injuries]. / Morfologicheskie kriterii trombogemorragicheskogo sindroma pri ostroi zakrytoi cherepno-mozgovoi travme.

The brain and viscera of 19 persons who had died from acute closed craniocerebral trauma were studied histologically (survey methods). Nonspecific and universal pathology was demonstrated in the system of blood aggregation regulation (BAR) in the form of the thrombohemorrhagic syndrome (THS) on the organ-tissue level. The authors have shown the efficacy of intervention in the BAR system in the presence of such pathology and the necessity of heparinization for preventing dystrophy in the brain (the organ liberating coagulants) and organs which had not suffered injury but were involved in the thrombohemorrhagic process under compulsion on the part of the activated blood, as well as for preventing and treating edema of the brain, lungs, and other organs.