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Transplant Proc ; 38(10): 3594-6, 2006 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-17175341

RESUMO

The aim of the study was to assess various T-cell subsets and cytokine secretion patterns both in liver tissue and in the peripheral blood of 24 liver transplant patients to assess possible specific immunological involvement in early acute rejection episodes after liver transplantation. Particularly, we studied CD4+ CD7+, CD8+ CD38+, and CD4+ CD25+ T cells by flow cytometry, as well as contemporaneously, interleukin (IL)-2 and IL-10 secretion by ELISpot to determine possible Th1-like immune responses and the immunomodulation expressed by Treg cells in acute liver rejection, respectively. As a control group we included patients transplanted without acute rejection. Early acute rejection within the first 4 weeks was proven histologically in 42% of patients. It was associated with a greater expression of CD4+ CD7+ and CD8+ CD38+ T cells in the liver than in the blood (P < .001). A contemporaneous reduced expansion of liver Treg cells was evident in patients with acute rejection (P < .001). Our data suggested that a preferential Th1-like immune mechanism operated in local fashion as characterized by a decreased presence in the liver and blood of Treg cells.


Assuntos
Rejeição de Enxerto/epidemiologia , Transplante de Fígado/imunologia , ADP-Ribosil Ciclase 1/análise , ADP-Ribosil Ciclase 1/sangue , Doença Aguda , Adulto , Antígenos CD/análise , Antígenos CD/sangue , Antígenos CD7/análise , Antígenos CD7/sangue , Biópsia , Antígenos CD4/análise , Antígenos CD4/sangue , Cadáver , Causas de Morte , Rejeição de Enxerto/patologia , Humanos , Subunidade alfa de Receptor de Interleucina-2/análise , Subunidade alfa de Receptor de Interleucina-2/sangue , Hepatopatias/classificação , Hepatopatias/cirurgia , Testes de Função Hepática , Transplante de Fígado/patologia , Pessoa de Meia-Idade , Seleção de Pacientes , Doadores de Tecidos
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