RESUMO
Twelve miniature pigs were inoculated with an attenuated African swine fever virus to study glomerular involvement in surviving pigs. In acute phase, kidneys were severely affected and displayed a glomerular capillary thrombosis with fibrin deposition in vascular lumen, detected by immunofluorescence. Fibrin-positive deposits were progressively cleared between one to three months after infection in surviving pigs. The histological picture in kidneys of surviving pigs, up to one post-infection year, showed a focal and segmental glomerulonephritis with hyalinosis, and IgM and C3 deposition was detected by immunofluorescence. Its pathogeny as an evolutive stage of acute glomerular injury is pointed out.
Assuntos
Febre Suína Africana/complicações , Glomerulonefrite/etiologia , Glomérulos Renais/patologia , Febre Suína Africana/patologia , Animais , Anticorpos/análise , Complexo Antígeno-Anticorpo/análise , Complemento C3/análise , Fibrina/análise , Imunoglobulina M/análise , Imuno-Histoquímica , Glomérulos Renais/química , Suínos , Viremia/patologiaRESUMO
Two patients with two and three types respectively of ground-glass hepatocyte inclusions are described. Both were hepatitis B surface antigen (HBsAG) positive and received cyanamide for alcohol aversion therapy. In addition, one of them had taken benzodiazepines and barbiturates. In one patient, cyanamide and HBsAg inclusions co-existed in the same hepatocytes.