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1.
Nanoscale ; 9(43): 16622-16626, 2017 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-29082396

RESUMO

Porphyrin- or phthalocyanine-bridged silsesquioxane nanoparticles (BSPOR and BSPHT) were prepared. Their endocytosis in MCF-7 cancer cells was shown with two-photon excited fluorescence (TPEF) imaging. With two-photon excited photodynamic therapy (TPE-PDT), BSPOR was more phototoxic than BSPHT, which in contrast displayed a very high signal for photoacoustic imaging in mice.

2.
Nanomedicine ; 13(4): 1447-1458, 2017 05.
Artigo em Inglês | MEDLINE | ID: mdl-28214608

RESUMO

In photodynamic therapy (PDT), the low absorptivity of photosensitizers in an aqueous environment reduces singlet oxygen generation efficiency and thereby decreases photosensitizing efficacy in biological conditions. To circumvent this problem, we designed a phthalocyanine-poly-L-glutamic acid conjugate (1-PG) made from a new phthalocyanine (Pc 1) monofunctionalized to allow adequate conjugation to PGA. The resulting 1-PG conjugate retained high absorptivity in the near-infrared (NIR) region at its λmax 675nm in an aqueous environment. The 1-PG conjugate demonstrated good singlet oxygen generation efficiency, increased uptake by 4 T1 breast cancer cells via clathrin-mediated endocytosis, and enhanced photocytotoxic efficacy. The conjugate also displayed a high light-dark toxicity ratio, approximately 1.5-fold greater than zinc phthalocyanine at higher concentration (10 µM), an important feature for the reduction of dark toxicity and unwanted side effects. These results suggest that the 1-PG conjugate could be a useful alternative for deep tissue treatment with enhanced anti-cancer (PDT) efficacy.


Assuntos
Ácido Glutâmico/química , Indóis/química , Nanoconjugados/química , Fotoquimioterapia , Fármacos Fotossensibilizantes/química , Animais , Linhagem Celular Tumoral , Endocitose , Isoindóis , Luz , Camundongos , Estrutura Molecular , Oxigênio Singlete/química
3.
Chem Commun (Camb) ; 50(56): 7466-8, 2014 Jul 18.
Artigo em Inglês | MEDLINE | ID: mdl-24874891

RESUMO

A one-step method to access to functionalized heteroleptic lanthanide double-decker complexes of phthalocyanine of A7B-type is reported. This optimized statistical method led to two hydroxylated model europium complexes, one of which was further converted into its mesylated and azido derivatives.

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