RESUMO
Ectodermal dysplasia (ED) is a hereditary genetic disorder that manifests a variety of deformities in one or more of the ectodermal derivatives. Ectodermal derivatives originate from ectodermal layers during embryonic development, such as skin, nails, hair, teeth, and exocrine glands. Over 150 variants of ED are reported in the literature. It has an incidence of seven in every 100,000 live births. There are two types of ED, which are hypohidrotic (anhidrotic) and hydrotic. The types are classified according to the degree of function of the sweat glands. This report discusses the case of a 13-month-old Saudi girl with typical features of ectodermal dysplasia who presented to a dermatology clinic.
RESUMO
Background Skin cancer is one of the most common cancers worldwide. However, limited studies have been conducted on this disease in Saudi Arabia. This study aimed to describe the prevalence, treatment modalities, and outcomes of skin cancer in a tertiary care hospital in western Saudi Arabia. Methods A retrospective review of the medical records of all Saudi patients visiting King Abdulaziz Medical City hospital in Jeddah between 1987 and 2016 was performed. Results In total, 132 patients were diagnosed with skin cancer during the study period, however, only 119 cases were analyzed because of missing information. The male-to-female ratio was 1.09:1. The age at diagnosis ranges from 16-94 (mean age: 63.3 years). The most common type of skin cancer was basal cell carcinoma, followed by squamous cell carcinoma and malignant melanoma. The most common anatomical site was the head and neck region. The most common form of treatment modality was surgery. Of the studied patients, 49.6% were cured, 20.2% were in remission, 12.6% relapsed, and 17.6% died. Conclusions This study showed an equal male to female ratio with variant cumulative incidence over the years. Surgery was the most common treatment modality and had the highest curative outcome. Primary care physicians should be probed further to raise awareness and screen their patients to ensure early detection of possible skin cancer.