RESUMO
We present a reconstituted lipoprotein-based nanoparticle platform comprising a curcumin fluorescent motif and an NIR responsive gold core. This multifunctional nanosystem is successfully used for aggregation-dependent fluorescence detection and photothermal disassembly of insoluble amyloid aggregates.
Assuntos
Peptídeos beta-Amiloides/análise , Curcumina/química , Corantes Fluorescentes/química , Ouro/química , Lipoproteínas/química , Nanopartículas/química , Fragmentos de Peptídeos/análise , Doença de Alzheimer/diagnóstico , Doença de Alzheimer/terapia , Peptídeos beta-Amiloides/ultraestrutura , Humanos , Raios Infravermelhos , Luz , Nanopartículas/ultraestrutura , Fragmentos de Peptídeos/ultraestrutura , Agregados Proteicos/efeitos da radiação , Espectrometria de Fluorescência/métodos , TemperaturaRESUMO
BACKGROUND AND IMPORTANCE: If ophthalmic artery's (OphA) origin anomalies are frequent, the superolateral origin of the OphA was rarely described. CLINICAL PRESENTATION: During an aneurysmal surgery, a superolateral origin of the left OphA was found. This variation was associated with a sylvian aneurysm. The anatomical, embryological features, the neurosurgical implications of this origin such as treatment of carotid-ophthalmic aneurysm or intra arterial retinoblastoma chemotherapy are discussed. CONCLUSION: To the best of our knowledge, this is a very rare operative case of both superolateral origin and initial course of OphA.
