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Hematol Oncol Stem Cell Ther ; 16(4): 316-322, 2023 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-37363985

RESUMO

Parvovirus B19 virus infection is widespread among humans because of its highly infectious and obstinate nature, with up to 80% of the population testing positive for IgG antibodies against the virus. Pronormoblasts observed in biopsy are the hallmarks of PVB19 infection. In addition, PVB19 affects the skin, heart, brain, joints, and liver and can be diagnosed through antibody detection or DNA detection via PCR. Due to its capsid proteins' high affinity for bone marrow receptors, its main presentation is the suppression of bone marrow functions. It has been shown to affect patients with hemolytic anemia and patients with hematological malignancies, presenting with pure red cell aplasia. The main available effective treatment option is IV immunoglobulins; however, the risk of recurrence remains high after treatment.


Assuntos
Eritema Infeccioso , Infecções por Parvoviridae , Parvovirus B19 Humano , Aplasia Pura de Série Vermelha , Humanos , Eritema Infeccioso/complicações , Eritema Infeccioso/patologia , Medula Óssea/patologia , Aplasia Pura de Série Vermelha/terapia , Parvovirus B19 Humano/genética , Infecções por Parvoviridae/complicações
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