Determination of metals in children's plastic toys using X-ray florescence spectroscopy.

Children's toys may contain substances that children can be exposed to via multiple pathways. The aim of this study was to assess the presence of metals in children's plastic toys using X-ray florescence. Fifty-six children's plastic toys were purchased from several wholesale markets, supermarkets, and retail stores in the UAE, and fifty-four out of them were labeled "Made in China." X-ray fluorescence analysis was conducted on 442 samples from 56 toys to investigate the elemental composition of the toy material. The elements detected with higher frequencies were Ti (100%), Cl (78.6%), Zn (67.9%), Si (66.1%), Iron (48.2%), and Cu (16.1%). Chromium and nickel were detected only in one toy with low concentrations, while Pb was not detected in any of the toys analyzed. In conclusion, the analyzed plastic toys contain metals and the presence of these metals in some cases may pose a health risk to children. Chlorine presence in more than three quarters of toys may indicate that the toys were made of PVC. The study revealed the presence of titanium and silicon in toys. However, more research is needed to verify their role in toys and to identify associated health risks. The study did not reveal toxic elements such as Pb, Cd, and As.

Formulation of Curcumin-ß-cyclodextrin-polyvinylpyrrolidone supramolecular inclusion complex: experimental, molecular docking, and preclinical anti-inflammatory assessment.

This research planned to ameliorate an aqueous solubility and dissolution of Curcumin (CUR) by the formulation of inclusion complex with ß-cyclodextrin (ß-CD) and polyvinylpyrrolidone (PVP). The phase solubility study was performed to assess the solubility of CUR. The prepared CUR complex assessed for dissolution study, physicochemical evaluation, in-vitro antioxidant activity, molecular modeling, and anti-inflammatory assessment. The pivotal findings of phase-solubility studies demonstrate apparent stability constant (Kc) and complexation efficiency (CE) values for CUR-ß-CD and CUR-ß-CD-PVP complex was 175.4 M -1, 1.15% and 833.3.2 M -1 and 5.21%, respectively. The characterization results revealed amorphization of crystalline state (CUR) into amorphous state. The maximum drug release found with the ternary CUR complex (F7), i.e. 45.41 ± 3.78% in 6 h study. The chemical shift in the NMR supports that the aromatic ring of CUR is completely complexed inside the ß-CD cavity. The antioxidant activity of pure CUR was found to be 58.02 ± 2.21% and CUR ternary complex (F7) showed significantly higher activity to 96.02 ± 2.46%. The in-vivo effect of CUR complex (F7) was also found significantly higher than that of pure CUR. The molecular modeling study depicted that PVP increased the stability of the ternary complex by forming the link between CUR and ß-CD. Thus, the ternary inclusion complex of CUR-ß-CD-PVP could contribute as an innovative outcome in the enhancement of solubility and in-vivo activity.