Entropy generation in a ciliary flow of an Eyring-Powell ternary hybrid nanofluid through a channel with electroosmosis and mixed convection.

Drug delivery systems, where the nanofluid flow with electroosmosis and mixed convection can help in efficient and targeted drug delivery to specific cells or organs, could benefit from understanding the behavior of nanofluids in biological systems. In current work, authors have studied the theoretical model of two-dimensional ciliary flow of blood-based (Eyring-Powell) nanofluid model with the insertion of ternary hybrid nanoparticles along with the effects of electroosmosis, magnetohydrodynamics, thermal radiations, and mixed convection. Moreover, the features of entropy generation are also taken into consideration. The system is modeled in a wave frame with the approximations of large wave number and neglecting turbulence effects. The problem is solved numerically by using the shooting method with the assistance of computational software "Mathematica" for solving the governing equation. According to the temperature curves, the temperature will increase as the Hartman number, fluid factor, ohmic heating, and cilia length increase. It is also disclosed that ternary hybrid nanoparticles result in a change in flow rate when other problem parameters are varied, and the same is true for temperature graphs. Engineers and scientists can make better use of nanofluid-based cooling systems in electronics, automobiles, and industrial processes with the aid of the study's findings.

Current Practice of Oral Care for Hematopoietic Stem Cell Transplant Patients: A Survey of the Eastern Mediterranean Blood and Marrow Transplantation Group.

INTRODUCTION: The oral cavity is one of the most common sites impacted by hematopoietic stem cell transplantation (HSCT) with acute complications including mucositis, bleeding, salivary gland dysfunction, infection, and taste alteration. These complications may result in significant morbidity and can negatively impact outcomes such as length of stay and overall costs. As such, oral care during HSCT for prevention and management of oral toxicities is a standard component of transplant protocols at all centers. The objective of this study was to evaluate the current oral care practices for patients during HSCT at different transplant centers within the Eastern Mediterranean region. MATERIAL AND METHODS: An internet-based survey was directed to 30 transplant centers in the Eastern Mediterranean region. The survey included five sections asking questions related to (1) transplant center demographics; (2) current oral care protocol used at the center and type of collaboration (if any) with a dental service; (3) use of standardized oral assessment tools and grading systems for mucositis; (4) consultations for management of oral complications; and (5) oral health needs at each center. Data are presented as averages and percentages. RESULTS: A total of 16 responses from 11 countries were collected and analyzed, indicating a response rate of 53%. Eight centers reported that a dentist was part of the HSCT team, with four reporting oral medicine specialists specifically being part of the team. Almost all centers (15/16; 93%) had an affiliated dental service to facilitate pre-HSCT dental clearance with an established dental clearance protocol at 14 centers (87%). Dental extraction was associated with the highest concern for bleeding and the need for platelet transfusion. With respect to infection risk, antibiotic prophylaxis was considered in the setting of low neutrophil counts with restorative dentistry and extraction. All centers provide daily reinforcement of oral hygiene regimen. The most frequently used mouth oral rinses included sodium bicarbonate (68%) and chlorhexidine gluconate (62%), in addition to ice chips for dry mouth (62%). The most frequently used mucositis assessment tools were the World Health Organization scale (7/16; 43%) and visual analogue scale for pain (6/16; 37%). Mucositis pain was managed with lidocaine solution (68.8%), magic mouth wash (68.8%) and/or systemic pain medications (75%). CONCLUSIONS: Scope and implementation of oral care protocols prior to and during HSCT varied between transplant centers. The lack of a universal protocol may contribute to gaps in oral healthcare needs and management for this group of patients. Further dissemination of and education around available oral care guidelines is warranted. CLINICAL RELEVANCE: Considering oral care during HSCT a standard component of transplant protocols, the current study highlights the common oral care practices for patients at centers within the Eastern Mediterranean region.

Numerical Case Study of Chemical Reaction Impact on MHD Micropolar Fluid Flow Past over a Vertical Riga Plate.

The purpose of this article is to investigate the mass and heat transport phenomena associated with micropolar fluid flow created by a vertically stretched Riga surface. This is constructed using an array of irregular electrodes and permanent magnets that are oriented spanwise. Additionally, we investigate the particles' micro rotational impacts. Furthermore, the flow behaviour of the modeled problem has been numerically calculated with bvp4c solver and the obtained results are presented graphically. Numerical data are used to illustrate physical parameters such as skin friction, Nusselt, and Sherwood numbers. For precise values of different flow parameters, the characteristics of fluid velocity, angular velocity, temperature, and concentration gradients are investigated graphically. The flowing parallel to the Riga plate in a positive x-path is aided by Lorentz forces introduced into the flowing simulation by the electro-magnetic poles of the Riga plate, which produces a rapidity greater than the inner speed. It is confirmed that the numerical calculations fit well with the results of earlier published investigations. Due to the participation of the Riga plate, the updated Hartmann number has a considerable effect on flow profiles.

Galerkin finite element analysis of magneto two-phase nanofluid flowing in double wavy enclosure comprehending an adiabatic rotating cylinder.

In this work, the finite element method is employed to simulate heat transfer and irreversibilities in a mixed convection two-phase flow through a wavy enclosure filled with water-alumina nanoliquid and contains a rotating solid cylinder in the presence of a uniform magnetic field. Impact of the variations of undulations number (0 ≤ N ≤ 5), Ra (103 ≤ Ra ≤ 106), Ha (0 ≤ Ha ≤ 100), and angular rotational velocity (- 500 ≤ Ω ≤ 500) were presented. Isotherms distribution, streamlines and isentropic lines are displayed. The governing equations are verified by using the Galerkin Finite Element Method (GFEM). The Nusselt numbers are calculated and displayed graphically for several parametric studies. The computational calculations were carried out using Buongiorno's non-homogeneous model. To illustrate the studied problem, a thorough discussion of the findings was conducted. The results show the enhacement of the maximum value of the flow function and the heat transfer process by increasing the value of Rayleigh number. Furthermore the irreversibility is primarily governed by the heat transfer component and the increment of the waviness of the active surfaces or the cylinder rotational velocity or hartmann number will suppress the fluid motion and hinders the heat transfer process.

Study on the mathematical modelling of COVID-19 with Caputo-Fabrizio operator.

In this article we study a fractional-order mathematical model describing the spread of the new coronavirus (COVID-19) under the Caputo-Fabrizio sense. Exploiting the approach of fixed point theory, we compute existence as well as uniqueness of the related solution. To investigate the exact solution of our model, we use the Laplace Adomian decomposition method (LADM) and obtain results in terms of infinite series. We then present numerical results to illuminate the efficacy of the new derivative. Compared to the classical order derivatives, our obtained results under the new notion show better results concerning the novel coronavirus model.

A descriptive study on dietary pattern and biophysical profile among Saudi female dental students.

OBJECTIVE: The current study aims to find out the dietary pattern among undergraduate dental students and evaluate its impact on their biophysical profile and academic achievement. METHODS: A convenient sample of 150 Saudi female dental students was selected as study participants, and a close-ended questionnaire divided into two parts was distributed among them.The questionnaire included questions on their eating habits, body mass index (BMI), waist-hip ratio (WHR), and blood pressure. The collected data was statistically analyzed using SPSS version 19, and the chi-square test, correlation analysis, and descriptive statistics were performed. RESULTS: It was observed that a majority (40%) of the study participants replaces their meals with snacks, and 26% did not take regular meals.The results reveal a significant association between blood pressure, BMI, and WHR among University female students. No significant association has been found between grade-point-average (GPA) and dietary pattern. CONCLUSIONS: The study concluded that the majority of university female students consumed unhealthy diets such as snacks. Fruit intake was lower than the recommended amount by World Health Organisation (WHO). Conducting appropriate nutrition related-public health programs would be beneficial in raising awareness regarding different aspects of dietary habits.

Carbon nanofiber-based multiplexed immunosensor for the detection of survival motor neuron 1, cystic fibrosis transmembrane conductance regulator and Duchenne Muscular Dystrophy proteins.

Simultaneous and point-of-care detection of multiple protein biomarkers has significant impact on patient care. Spinal Muscular Atrophy (SMA), Cystic Fibrosis (CF) and Duchenne Muscular Dystrophy (DMD) are well known progressive hereditary disorders associated with increased morbidity as well as mortality. Therefore, rapid detection of biomarkers specific for these three disorders in newborns offers new opportunities for early diagnosis, delaying symptoms and effective treatment. Here, we report the development of a disposable carbon nanofiber (CNF)-based electrochemical immunosensor for simultaneous detection of survival motor neuron 1 (SMN1), cystic fibrosis transmembrane conductance regulator (CFTR) and DMD proteins. The CNF-modified array electrodes were first functionalized by electroreduction of carboxyphenyl diazonium salt. Then, the immunosensor was fabricated by the covalent immobilization of the three antibodies on the working electrodes of the array sensor via carbodiimide (EDC/NHS) chemistry. Simultaneous detection of CFTR, DMD and SMN1 was achieved with high sensitivity and detection limits of 0.9 pg/ml, 0.7 pg/ml and 0.74 pg/ml, respectively. The multiplexed immunosensor has also shown strong selectivity against non-specific proteins. Moreover, high recovery percentage was obtained when the immunosensor was applied in spiked whole blood samples. This voltammetric immunosensor offers cost effective, easy to use, rapid and high throughput potential screening method for these three hereditary disorders using only few drops of blood.

Electrochemical immunosensors for the detection of survival motor neuron (SMN) protein using different carbon nanomaterials-modified electrodes.

Spinal muscular atrophy is an untreatable potentially fatal hereditary disorder caused by loss-of-function mutations in the survival motor neuron (SMN) 1 gene which encodes the SMN protein. Currently, definitive diagnosis relies on the demonstration of biallelic pathogenic variants in SMN1 gene. Therefore, there is an urgent unmet need to accurately quantify SMN protein levels for screening and therapeutic monitoring of symptomatic newborn and SMA patients, respectively. Here, we developed a voltammetric immunosensor for the sensitive detection of SMN protein based on covalently functionalized carbon nanofiber-modified screen printed electrodes. A comparative study of six different carbon nanomaterial-modified electrodes (carbon, graphene (G), graphene oxide (GO), single wall carbon nanotube (SWCNT), multi-wall carbon nanotube (MWCNT), and carbon nanofiber (CNF)) was performed. 4-carboxyphenyl layers were covalently grafted on the six electrodes by electroreduction of diazonium salt. Then, the terminal carboxylic moieties on the electrodes surfaces were utilized to immobilize the SMN antibody via EDC/NHS chemistry and to fabricate the immunosensors. The electrochemical characterization and analytical performance of the six immunosensors suggest that carbon nanofiber is a better electrode material for the SMN immunosensor. The voltammetric SMN carbon nanofiber-based immunosensor showed high sensitivity (detection limit of 0.75pg/ml) and selectivity against other proteins such as cystic fibrosis transmembrane conductance regulator (CFTR) and dystrophin (DMD). We suggest that this novel biosensor is superior to other developed assays for SMN detection in terms of lower cost, higher sensitivity, simplicity and capability of high throughput screening.

The benefit of consolidation radiotherapy to initial disease bulk in patients with advanced Hodgkin's disease who achieved complete remission after standard chemotherapy.

BACKGROUND/PURPOSE: The aim of this study was to evaluate the role of consolidation radiotherapy (RT) in advanced-stage Hodgkin's disease (HD) with initial bulky sites after radiological complete remission (CR) or partial response (PR) with positron emission tomography-negative (metabolic CR) following standard chemotherapy (ABVD [Adriamycin, bleomycin, vinblastine, and dacarbazine]) six to eight cycles. PATIENTS AND METHODS: Adult patients with advanced-stage HD treated at our institute during the period 2006 to 2012 were retrospectively evaluated. One hundred and ninety-two patients with initial bulky disease size (>7 cm) who attained radiological CR/PR and metabolic CR were included in the analysis. One hundred and thirteen patients who received radiotherapy (RT) as consolidation postchemotherapy (RT group) were compared to 79 patients who did not receive RT (non-RT group). Disease-free (DFS) and overall survival (OS) rates were estimated using the Kaplan-Meier method and were compared according to treatment group by the log-rank tests at P ≤0.05 significance level. RESULTS: The mean age of the cohort was 33 (range: 14 to 81) years. Eighty-four patients received involved-field radiation and 29 patients received involved-site RT. The RT group had worse prognostic factors compared to the non-RT group. Thirteen (12%) relapses occurred in the RT group, and 19 (24%) relapses occurred in the non-RT group. Nine patients (8%) in the RT group died, compared to eleven patients (14%) in the non-RT group. Second malignancies were seen in only five patients: three patients in the RT group compared to two patients in the non-RT group. At 5 years, overall DFS was 79%±9% and OS was 85%±9%. There was significant statistical difference between the RT group and the non-RT group regarding 5-year DFS: 86%±7% and 74%±9%, respectively (P ≤0.02). However, the 5-year OS was 90%±5% for the RT group and 83%±8% for the non-RT group, with no statistical difference (P ≤0.3). CONCLUSION: The results of our study suggest that consolidation RT in patients with advanced-stage HD with initial bulky disease who had postchemotherapy radiologic CR or PR with metabolic CR improved the DFS.