1.
Bioorg Med Chem
; 6(6): 735-42, 1998 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-9681139
RESUMO
A series of isoindolo[2,1-a]- and pyrrolo[1,2-a]quinolines were designed and synthesized for DNA-gyrase and topoisomerase-II inhibition studies. Some of the compounds showed significant activity against the enzymes.
Assuntos
Inibidores Enzimáticos/síntese química , Indóis/síntese química , Pirróis/síntese química , Quinolinas/síntese química , Inibidores da Topoisomerase II , Bactérias/enzimologia , Inibidores Enzimáticos/química , Inibidores Enzimáticos/farmacologia , Humanos , Indóis/química , Indóis/farmacologia , Pirróis/química , Pirróis/farmacologia , Quinolinas/química , Quinolinas/farmacologia , Relação Estrutura-Atividade
2.
Bioorg Med Chem Lett
; 8(1): 97-100, 1998 Jan 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-9871636
RESUMO
Ellagic acid was found to inhibit E. coli DNA gyrase supercoiling with approximately the same potency as nalidixic acid. Tricyclic analogs of ellagic acid, which vary in the number and position of the hydroxy groups as well as their replacement with halogens, have been synthesized. The biological activity of these analogs is discussed.
