RESUMO
ABSTRACT: In the April 1930 issue of the journal, Founding Editor-in-Chief William Rush Dunton, Jr, MD, initiated a new series: Museum Meanderings. Eleven installments of the series ran intermittently until December 1931. Here, a 12th installment, an e-museum "tour" of paintings by the great American artist Jacob Lawrence (1917-2000) relevant to rehabilitation medicine, is offered. In particular, his Occupational Therapy No. 1 (1949) is a most thought-provoking and inspiring masterpiece. The painting depicts five women performing various sewing activities with space in the painting brilliantly divided. The painting has been discussed by art critics, but it has not been appreciated that all the women appear actually to be the same person! Thus, the painting shows the stages or cycle of rehabilitation. Echoing Rush Dunton's thoughts in 1930, we invite further contributions to the series.
Assuntos
Medicina , Terapia Ocupacional , Pinturas , Humanos , Feminino , Museus , Pinturas/históriaRESUMO
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces immune-mediated type 1 interferon (IFN-1) production, the pathophysiology of which involves sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) tetramerization and the cytosolic DNA sensor cyclic-GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway. As a result, type I interferonopathies are exacerbated. Aspirin inhibits cGAS-mediated signaling through cGAS acetylation. Acetylation contributes to cGAS activity control and activates IFN-1 production and nuclear factor-κB (NF-κB) signaling via STING. Aspirin and dapsone inhibit the activation of both IFN-1 and NF-κB by targeting cGAS. We define these as anticatalytic mechanisms. It is necessary to alleviate the pathologic course and take the lag time of the odds of achieving viral clearance by day 7 to coordinate innate or adaptive immune cell reactions.
Assuntos
Tratamento Farmacológico da COVID-19 , Interferon Tipo I , Humanos , Acetilação , NF-kappa B/metabolismo , Reposicionamento de Medicamentos , Proteínas de Membrana/metabolismo , SARS-CoV-2 , Nucleotidiltransferases/metabolismo , Interferon Tipo I/metabolismo , Aspirina , Imunidade Inata/genéticaRESUMO
ABSTRACT: The American Journal of Physical Medicine & Rehabilitation has entered its second century of publication. In this centennial review, we chronicle the evolution of the journal from its origin in 1922 as the Archives of Occupational Therapy to the present. In particular, we focus on the contributions to the journal and the field of physical medicine and rehabilitation by Founding Editor-in-Chief William Rush Dunton, Jr, MD, and the rise of publication of randomized controlled studies in the journal, thus fulfilling Dr Dunton's original vision and dream for the field and the journal.
Assuntos
Terapia Ocupacional , Medicina Física e Reabilitação , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Estados UnidosRESUMO
A 66-year-old left-handed male was admitted to our acute inpatient rehabilitation (AIR) unit following a resection of the right occipito-parietal glioblastoma. He presented with symptoms of horizontal oculomotor apraxia, contralateral optic ataxia and left homonymous hemianopsia. We diagnosed this patient with partial Bálint's syndrome (BS)- oculomotor apraxia, optic ataxia but not simultanagnosia. BS is typically caused by bilateral posterior parietal lesions, but we here describe a unique case due toresection of a right intracranial tumor. A short AIR stay allowed our patient to learn how to compensate for visuomotor and visuospatial deficits, and improved his quality of life significantly.
Assuntos
Agnosia , Apraxias , Encefalopatias , Glioblastoma , Humanos , Masculino , Idoso , Agnosia/etiologia , Hemianopsia/complicações , Glioblastoma/complicações , Qualidade de Vida , Ataxia/etiologia , Apraxias/etiologia , Encefalopatias/complicaçõesAssuntos
Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/terapia , Departamentos Hospitalares/organização & administração , Admissão do Paciente/estatística & dados numéricos , Medicina Física e Reabilitação , Pneumonia Viral/epidemiologia , Pneumonia Viral/terapia , COVID-19 , Planejamento Hospitalar , Humanos , Cidade de Nova Iorque/epidemiologia , PandemiasAssuntos
Betacoronavirus , Colchicina/uso terapêutico , Infecções por Coronavirus/complicações , Dapsona/uso terapêutico , Olanzapina/uso terapêutico , Pneumonia Viral/complicações , Síndrome do Desconforto Respiratório/tratamento farmacológico , Adulto , COVID-19 , Quimiotaxia de Leucócito/efeitos dos fármacos , Colchicina/administração & dosagem , Dapsona/administração & dosagem , Humanos , Interleucina-8/fisiologia , Neutrófilos/efeitos dos fármacos , Olanzapina/administração & dosagem , Pandemias , Síndrome do Desconforto Respiratório/etiologia , SARS-CoV-2Assuntos
Transtornos de Deglutição/diagnóstico , Aspiração Respiratória/diagnóstico , Vertigem/diagnóstico , Transtornos de Deglutição/complicações , Transtornos de Deglutição/terapia , Diagnóstico Diferencial , Feminino , Humanos , Ilustração Médica , Pessoa de Meia-Idade , Aspiração Respiratória/etiologia , Vertigem/etiologiaAssuntos
Apraxias , Fala , Apraxias/diagnóstico por imagem , Apraxias/etiologia , Lobo Frontal , HumanosRESUMO
The role and function that proprioception plays in movement and motor learning have been debated since the 19th century but can be difficult to isolate and study. Lesions at various points along the proprioceptive pathway result in afferent paresis that can be significantly disabling. Compensatory mechanisms can help with successful rehabilitation and provide an opportunity to study the role of these mechanisms in sensory feedback. Here, we present two cases of adult patients with complete hemisensory loss after a stroke: one patient with a cortical stroke and the other one with a thalamic stroke. First, we see that that motor learning can occur without proprioception, with the help of visual feedback. Second, proprioception plays an important role in movement: in the upper limb, it can facilitate individual finger movements, and in the lower limb, it maintains sufficient knee flexion to prevent the knee from going into recurvatum (backward bending) during ambulation.
Assuntos
Paresia/reabilitação , Propriocepção , Reabilitação do Acidente Vascular Cerebral , Acidente Vascular Cerebral/fisiopatologia , Idoso , Retroalimentação Sensorial , Feminino , Humanos , Extremidade Inferior/fisiopatologia , Masculino , Pessoa de Meia-Idade , Movimento , Paresia/etiologia , Paresia/fisiopatologia , Acidente Vascular Cerebral/complicações , Resultado do Tratamento , Extremidade Superior/fisiopatologiaRESUMO
This professional opinion describes the use of an off the shelf knee orthotic to correct the gait and functional mobility of a patient with hemisensory loss including proprioception following a stroke and provides supporting video. Interestingly, this case corrects a human analogue of a functional deficit found experimentally in monkeys in the 19th century by Mott and Sherrington.
Assuntos
Delusões/fisiopatologia , Extremidade Inferior/fisiopatologia , Paresia/fisiopatologia , Transtornos da Percepção/fisiopatologia , Acidente Vascular Cerebral/fisiopatologia , Tálamo/patologia , Extremidade Superior/fisiopatologia , Idoso , Delusões/reabilitação , Feminino , Humanos , Paresia/reabilitação , Transtornos da Percepção/etiologia , Transtornos da Percepção/reabilitação , Acidente Vascular Cerebral/complicações , Acidente Vascular Cerebral/patologiaAssuntos
Terapia Combinada/métodos , Neuralgia/terapia , Manejo da Dor/métodos , Acidente Vascular Cerebral/terapia , Doenças Talâmicas/terapia , Vibração , Habituação Psicofisiológica , Humanos , Modalidades de Fisioterapia , Risco , Reabilitação do Acidente Vascular Cerebral , Resultado do TratamentoRESUMO
Post-traumatic stress disorder (PTSD) can follow war trauma, sexual abuse, other traumas, and even be experienced by commanders for the PTSD of their subordinates. Medications and counseling are sometimes not effective, so new treatments are needed. Some years ago, I suggested that animal-assisted therapy (AAT) (pet therapy) might be beneficial for PTSD. A large randomized controlled trial is underway of canine-assisted therapy for PTSD. Randomized controlled trials are most useful in assessing the efficacy of a medical intervention as these trials control for known and unknown biases. However, due to their very nature and rigorous requirements, knowledge gained from randomized controlled trials may need to be supplemented from other kinds of studies. Here, I note that media reports of AAT for PTSD may effectively function as case reports and suggest further studies: For PTSD, these demonstrate that (1) AAT can be dramatically effective in improving PTSD symptoms; (2) there is the potential for benefit from AAT by multiple different animals besides canines for PTSD; and (3) AAT may have a role in preventing suicide in patients with PTSD.