[Is propofol (Diprivan) indicated in emergency surgery?]. / Pokazan li e propofol (Diprivan) v speshnata khirurgiia.

Propofol is an anesthetic characterized by specific pharmacologic qualities, conditioning compliance of the clinical picture with the drug infusional rate, high-degree safety and facilitated anesthesia conduction--qualities by which it bears resemblance to inhalation anesthesia. This is an assessment of the qualities of TIVA with Propofol in poor-risk patients according to ASA, operated on an emergency basis. Proceeding from the obtained results, the inference is reached that continuous Propofol infusion provides for adequate anesthesia control and safety of the patients with heightened anesthesiologic and operative risk.

[Prolonged propofol (Diprivan) infusion for sedation in the critically ill]. / Produlzhitelna infuziia na propofol (Diprivan) za sedirane na kritichni bolni.

Continued sedation has important practical implications on overcoming the physical and psychic stress which in turn, has important practical implications on the well-being of patients in conditions of intensive care unit. It is the purpose of the study to assess the quality and characteristics of sustained sedation with constant propofol (Diprivan) and fentanyl infusion. As a result of the study the inference is reached that sedation with Diprivan and fentanyl, administered as constant infusion, lends itself readily to control, and what is more, it is free of noteworthy side effects. To secure permanent sedation it is necessary to adapt the infusional rate to the clinical signs in compliance with the concrete patient and individual needs.

[Propofol (Diprivan) in emergency anesthesia]. / Propofol (Diprivan) v speshnata anesteziia.

This is an assessment of the effect of propofol (Diprivan) as a hypnotic component of total intravenous anesthesia (TIVA) in conjunction with alfentanyl (Rapifen), securing the antinociceptive component, and atracurium (Tracrium) as myorelaxant. The aforementioned constellation is used with the goal to attain a much better control of TIVA, substantiated both pharmacokinetically and pharmacodynamically. This type of anesthesia is applied to 15 patients presenting acute surgical diseases, classified III-IV degree according to ASA. The technique used and the dosage of drugs, introduced by infusion, are described. The basic respiratory and cardiocirculatory parameters are evaluated. Assessment is done of the quality of analgesia with description of the character of the awakening and recovery phases in terms of time and quality. The preliminary study, covering patients with increased anesthesiological risk, shows that the doses given are appreciably reduced in the period of maintaining anesthesia (4-5 mg/kg/h Propofol, 1-1.5 mg/h Rapifen in patients with mean body weight 70 kg). The prophylaxis against operative stress is estimated as very good. TIVA with Diprivan/Rapifen/Tracrium lends itself readily to control.