Evaluation of changes in the upper airway after Twin Block treatment in patients with Class II malocclusion.

The purpose of this prospective case control study is to describe in growing patients with mandibular hypoplasia, treatment outcomes following functional therapy in terms of volumetric changes in nasopharynx and oropharynx, that is, upper and lower pharynx. We recruited 60 study participants aged between 8 and 12 years having mandibular Class II malocclusion and a reduced upper airway (UA) size, as determined by McNamara cephalometric analyses. Forty patients received Twin Block treatment, whereas the remaining 20 patients did not receive treatment, thus constituting the control group. The control group included patients who did not start treatment after their first visit but returned for a consultation one or 2 years later. All patients underwent an initial teleradiography examination of the skull and a final teleradiography examination to measure changes using McNamara cephalometric analysis of the UA. Pretreatment and posttreatment changes were assessed using Student's t test for independent samples with a significance level of 0.05. Both anatomical structures analyzed-the upper pharynx (nasopharynx) and lower pharynx (oropharynx)-showed significant increases after treatment regardless of whether the patients were boys or girls. The controls showed a decrease in UA size on average after approximately 2 years of growth. A clear relationship exists between the mandibular advancement achieved with TB treatment and an increased UA size. Therefore, the appliance is considered suitable for improving the respiratory quality of growing patients with a decreased UA size.

Immunohistochemical profile of human pancreatic pacinian corpuscles.

OBJECTIVES: To analyze the immunohistochemical profile of the human pancreatic pacinian corpuscles in comparison with that of the cutaneous pacinian corpuscles. In addition, we studied a Pacinilike corpuscle found in the adventitia of a pancreatic artery. METHODS: We used immunohistochemistry to detect specific antigens for corpuscular constituents, specific antibodies for the identification of Adelta- and C-sensory fibers and for the detection of several growth factor receptors, and some members of the degenerin/epithelial Na channel superfamily of proteins. RESULTS: Approximately 62% of pancreatic pacinian corpuscles have 2 to 10 axonic profiles each enclosed by its own inner core: 1 or 2 of these axonic profiles displayed RT-97 immunoreactivity (specific marker of mechanical axons). The cutaneous pacinian corpuscles showed not more than 2 axonic profiles with identical immunohistochemical characteristics. The expression of glial fibrillary acidic protein, epithelial membrane antigen, and tyrosine receptor kinase B was different between pancreatic and cutaneous pacinian corpuscles; the pattern of distribution of degenerin/epithelial Na channel proteins was identical in both cases. The arterial Pacinilike corpuscles displayed a specific immunohistochemical profile. CONCLUSIONS: Pancreatic pacinian corpuscles slightly differ from the cutaneous ones, and these differences could be related to topography, growth factor requirements, or function of pacinian corpuscles in the pancreas.