Social cognition in psychosis: Predictors and effects of META-cognitive training.

Social cognition deficits are found in schizophrenia and bipolar disorder, but its neural underpinnings are poorly understood. Given the complexity of psychological functions underlying this kind of cognition, we hypothesized that alterations in global structural connectivity could contribute to those deficits. To test this hypothesis, we studied a group of schizophrenia and bipolar patients with connectomics based on diffusion magnetic resonance imaging and assessments of general and social cognition. The latter was assessed using the Mayer, Salovey and Caruso Emotional Intelligence Test (MSCEIT) for emotional intelligence and the Spanish Group for Schizophrenia Treatment Optimization (Grupo Español para la OPtimización del Tratamiento de la Esquizofrenia, GEOPTE) test for behavioral aspects of social cognition. Graph theory applied to fractional anisotropy for the connections among cortical regions was used to obtain the small-world (SW) index of the structural connectivity network. In addition, we assessed the possibility of predicting the response of social cognition deficits to Meta-cognitive Training based on their possible underpinnings in a subgroup of patients. Patients showed lower scores in emotional intelligence and behavioral social cognition. MSCEIT scores were associated with SW index and working memory, and GEOPTE scores were related to verbal memory. Improvement in social cognition after Meta-cognitive Training was associated with lower scores of the social cognition in the baseline, according to the GEOPTE scale. Our findings support structural connectivity as one of the factors underlying emotional intelligence in schizophrenia, and the use of Meta-cognitive Training to improve social cognition in patients with larger deficits.

Síndrome opsoclonus-mioclonus secundario a intoxicación por duloxetina / Opsoclonus-myoclonus syndrome secondary to duloxetine poisoning

Introducción: El síndrome opsoclonus-mioclonus es una entidad poco frecuente, de origen autoinmune y que puede aparecer a cualquier edad, siendo mucho más frecuente en la edad pediátrica. Su etiología es muy diversa, frecuentemente paraneoplásica o de origen infeccioso. Los casos secundarios a intoxicación por drogas o medicamentos son infrecuentes. Caso clínico: Mujer de 43 años valorada por Psiquiatría de Enlace por sobreingesta de 80 comprimidos de duloxetina 30mg. Acude a Urgencias por un cuadro de inicio brusco de visión borrosa, temblor generalizado, dificultad para caminar y alucinaciones visuales. Ingresa en Neurología por sospecha de síndrome opsoclonus-mioclonus, recibe tratamiento esteroideo precoz, tras el que se observa mejoría clínica y recuperación temprana. Las pruebas complementarias resultan normales, excepto los niveles de duloxetina, que están muy por encima del rango normal. Discusión: El síndrome opsoclonus-mioclonus es un trastorno del movimiento infrecuente, que requiere una correcta evaluación debido a la posibilidad de estar relacionado con neoplasias subyacentes

Introduction: Opsoclonus-myoclonus syndrome is a rare entity of autoimmune origin, which can appear at any age, being much more common in paediatric patients. Its aetiology is very diverse, often of para-neoplastic or of infectious origin. Cases secondary to poisoning by drugs or other kind of medication are uncommon. Clinical case: A 43 year-old woman was examined by Liaison Psychiatry due to an overdose of 80 tablets of duloxetine 30mg. The patient went to the Emergency Service due to a sudden onset of blurred vision, general tremor, difficulty to walk, and visual hallucinations. She was admitted to the Neurology Department due to a clinical suspicion of opsoclonus-myoclonus syndrome. She received early steroid treatment, after which both clinical improvement and early recovery were observed. Complementary tests were normal except for duloxetine levels, which were found to be well above their normal range. Discussion: Opsoclonus-myoclonus syndrome is an uncommon disorder, which requires a correct diagnostic evaluation and analysis, as it could possibly be related to underlying neoplasms