Assuntos
Dermatoses Faciais/diagnóstico por imagem , Granuloma/diagnóstico por imagem , Ultrassonografia Doppler , Abscesso/diagnóstico , Pré-Escolar , Diagnóstico Diferencial , Cisto Epidérmico/diagnóstico , Granuloma Piogênico/diagnóstico , Humanos , Masculino , Pioderma/diagnóstico por imagem , Remissão EspontâneaAssuntos
DNA/genética , Mutação de Sentido Incorreto , Dermatopatias/congênito , Pele/patologia , Transglutaminases/genética , Biópsia , Pré-Escolar , Análise Mutacional de DNA , Feminino , Humanos , Masculino , Dermatopatias/diagnóstico , Dermatopatias/enzimologia , Dermatopatias/genética , Transglutaminases/metabolismoRESUMO
Toll-like receptors (TLRs) have achieved an extraordinary amount of interest in cancer research due to their role in tumor progression. The aim of this study was to investigate the expression and clinical relevance of TLR3, 4, 7 and 9 in cutaneous malignant melanoma (CMM). The expression levels of TLR3, 4, 7 and 9 were analyzed in tumors from 30 patients with CMM. The analysis was performed by immunohistochemistry, and the results were correlated with various clinicopathological findings and with relapse-free survival. Our results indicate that there was a wide variability in the immunostaining score values for each receptor. Positive staining for TLRs was generally found in tumor cells, especially for TLR4 and TLR9. Nevertheless, a significant percentage of tumors also showed TLR4 expression in mononuclear inflammatory cells (62.1 %) and in fibroblast-like cells (34.5 %). Our results showed no significant association between score values for each TLR and clinicopathological characteristics of patients. However, our results demonstrated that high TLR4 expression was significantly associated with a shortened relapse-free survival (p = 0.001). Therefore, TLR4 expression may be a new prognostic factor of unfavorable evolution in cutaneous malignant melanoma.
Assuntos
Biomarcadores Tumorais/análise , Melanoma/imunologia , Neoplasias Cutâneas/imunologia , Receptor 3 Toll-Like/análise , Receptor 4 Toll-Like/análise , Receptor 7 Toll-Like/análise , Receptor 8 Toll-Like/análise , Adulto , Idoso , Idoso de 80 Anos ou mais , Distribuição de Qui-Quadrado , Intervalo Livre de Doença , Feminino , Humanos , Imuno-Histoquímica , Estimativa de Kaplan-Meier , Masculino , Melanoma/mortalidade , Melanoma/patologia , Melanoma/terapia , Pessoa de Meia-Idade , Neoplasias Cutâneas/mortalidade , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/terapia , Fatores de Tempo , Resultado do Tratamento , Regulação para Cima , Adulto JovemRESUMO
No disponible
Assuntos
Humanos , Feminino , Idoso , Lúpus Eritematoso Sistêmico/complicações , Pneumonia em Organização Criptogênica , Tosse/etiologia , Radiografia TorácicaRESUMO
Pulmonary Langerhans'-cell histiocytosis belongs to a spectrum of diseases characterized by monoclonal proliferation and infiltration of organs by Langerhans' cells. It is an uncommon interstitial lung disease of unknown etiology occurring almost exclusively in cigarette smokers. It s course in adults is variable and unpredictable, ranging from benign self-limiting types with spontaneous regression to slowly progressive malignant disease that leads to respiratory failure and death. We report one patient diagnoses of pulmonary Langerhans' cell histiocytosis who experimented an objective radiographic improvement and disappearance of symptoms after smoking cessation.
Assuntos
Histiocitose de Células de Langerhans/diagnóstico , Adulto , Humanos , Pulmão/diagnóstico por imagem , Pulmão/patologia , Masculino , Radiografia , Remissão Espontânea , Abandono do Hábito de FumarRESUMO
La histiocitosis pulmonar de células de Langerhans forma parte de un espectro de enfermedades caracterizadas por la proliferación monoclonal y la infiltración de distintos órganos por células de Langerhans. Es una enfermedad pulmonar intersticial de etiología desconocida que ocurre casi exclusivamente en pacientes fumadores. El curso de esta enfermedad en adultos es impredecible, oscilando desde formas benignas autolimitadas, hasta formas malignas con evolución progresiva hacia el fallo respiratorio y la muerte. Presentamos el caso de un paciente diagnosticado de histiocitosis pulmonar de células de Langerhans que presentó una mejoría clínica y radiográfica tras abandonar el hábito tabáquico
Pulmonary Langerhans´- cell histiocytosis belongs to a spectrum of diseases characterized by monoclonal proliferation and infiltration of organs by Langerhans´cells. It is an uncommon interstitial lung disease of unknown etiology occurring almost exclusively in cigarette smokers. It´s course in adults is variable and unpredictable, ranging from benign self-limiting types with spontaneous regression to slowly progressive malignant disease that leads to respiratory failure and death. We report one patient diagnoses of pulmonary Langerhans´cell histiocytosis who experimented an objetive radiographic improvement and disappearance of symptoms after smoking cessation
Assuntos
Masculino , Adulto , Humanos , Histiocitose de Células de Langerhans/patologia , Histiocitose de Células de Langerhans/etiologia , Tabagismo/complicações , Tomografia Computadorizada por Raios XRESUMO
Whipple's disease is a rare systemic infectious disease caused by the bacterium Tropheryma whippelii. Early diagnosis is essential. Whipple's disease is potentially fatal but responds dramatically to antibiotic treatment. The diagnosis is confirmed by means of polymerase chain reaction (PCR) technology. This analysis may be useful for monitoring the efficacy of therapy. The recommended treatment al present is administration of cotrimoxazole twice daily for one year. When CNS involvement occurs, it is recommended initial treatment with daily parenteral administration of streptomycin 1 g and 1.2 million units of benzyl penicillin (Penicillin G) over a period of 14 days.
Assuntos
Doença de Whipple/diagnóstico , Idoso , Anemia/etiologia , Artrite Infecciosa/diagnóstico , Artrite Infecciosa/etiologia , Biópsia , DNA Bacteriano/isolamento & purificação , Diarreia/etiologia , Duodenopatias/etiologia , Duodenopatias/microbiologia , Duodenopatias/patologia , Feminino , Ácido Fólico/uso terapêutico , Hemorragia Gastrointestinal/etiologia , Bactérias Gram-Positivas/genética , Bactérias Gram-Positivas/isolamento & purificação , Insuficiência Cardíaca/etiologia , Doenças das Valvas Cardíacas/etiologia , Doenças das Valvas Cardíacas/cirurgia , Humanos , Laparotomia , Masculino , Penicilina G/uso terapêutico , Reação em Cadeia da Polimerase , Estreptomicina/uso terapêutico , Combinação Trimetoprima e Sulfametoxazol/uso terapêutico , Redução de Peso , Doença de Whipple/tratamento farmacológicoRESUMO
La enfermedad de Whipple, también conocida como lipodistrofia intestinal, es un proceso infeccioso, multisistémico y poco frecuente, causado por la bacteria Tropheryma whippelii. El diagnóstico precoz es fundamental porque esta enfermedad es potencialmente letal, pero responde espectacularmente al tratamiento antibiótico. El diagnóstico se confirma con la reacción en cadena de la polimerasa (PCR) que también es útil para monitorizar la respuesta al tratamiento. Actualmente el tratamiento recomendado consiste en la administración de cotrimoxazol oral dos veces al día durante un año. Cuando hay afectación del SNC se aconseja iniciar el tratamiento con la administración intramuscular de 1 gramo de estreptomicina asociado a 1,2 MU de bencil penicilina (penicilina G) de forma diaria durante 14 días
Whipples disease is a rare systemic infectious disease caused by the bacterium Tropheryma whippelii. Early diagnosis is essential. Whipples disease is potentially fatal but responds dramatically to antibiotic treatment. The diagnosis is confirmed by means of polymerase chain reaction (PCR) technology. This analysis may be useful for monitoring the efficacy of therapy. The recommended treatment al present is administration of cotrimoxazole twice daily for one year. When CNS involvement occurs, it is recommended initial treatment with daily parenteral administration of streptomycin 1 g and 1,2 million units of benzyl penicillin (Penicillin G) over a period of 14 days
Assuntos
Adulto , Humanos , Doença de Whipple/diagnóstico , Doença de Whipple/patologia , Combinação Trimetoprima e Sulfametoxazol/síntese química , Combinação Trimetoprima e Sulfametoxazol , Macrófagos/classificação , Doença de Whipple/etiologia , Reação em Cadeia da Polimerase , Macrófagos/fisiologia , Tomografia Computadorizada por Raios X/métodosRESUMO
Anetoderma is a rare elastolytic disorder included within the group of cutaneous atrophies. Its pathogenesis is not yet clearly established, but immunological mechanisms could play an important role in dermal elastolysis. It has been associated with different autoantibodies and autoimmune disorders. We present a case of anetoderma in a systemic lupus erythematosus patient with anti-proliferating-cell-nuclear-antigen and antiphospholipid antibodies, highlighting the peculiarities of such an association.
