1.
Crit Rev Oncol Hematol
; 199: 104387, 2024 Jul.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38734279
RESUMO
DNA mismatch repair (MMR) deficiency and the associated microsatellite instability (MSI) phenotype has become a subject of enormous interest in recent years due to the demonstrated efficacy of immune checkpoint inhibitors (ICI) in advanced tumours. Assessing MSI in patients with gastrointestinal tract (GI) cancers is useful to exclude Lynch syndrome, but also to predict benefit for ICI. Following review of the relevant literature, this review article aims to outline the clinicopathologic spectrum of MSI and mismatch repair deficiency (dMMR) in the GI tract, hepatobiliary system and pancreas and discuss the therapeutic consideration in this disease.
Assuntos
Reparo de Erro de Pareamento de DNA , Neoplasias Gastrointestinais , Instabilidade de Microssatélites , Humanos , Neoplasias Gastrointestinais/genética , Neoplasias Gastrointestinais/tratamento farmacológico , Neoplasias Gastrointestinais/patologia , Reparo de Erro de Pareamento de DNA/genética , Inibidores de Checkpoint Imunológico/uso terapêutico
2.
Eur J Cancer Care (Engl)
; 30(6): e13489, 2021 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34278633