RESUMO
A wide variety of novel small-molecule natural products has recently been reported. These compounds were isolated from marine and terrestrial sources, and from a variety of animals, plants and microorganisms. With the breadth of diversity represented in these bioactive small molecules, the future of natural product drug discovery looks bright.
Assuntos
Desenho de Fármacos , Actinobacteria/química , Animais , Anuros , Fungos/química , Myxococcales/química , Plantas/química , Urocordados/químicaRESUMO
Two new 1,2,3,4-tetrahydroanthraquinones, auxarthrol A (compound 1) and auxarthrol B (2), along with three known pyrrolyloctatetraenyl-alpha-pyrone pigments, auxarconjugatin A (3), auxarconjugatin B (4) and rumbrin (5), were isolated from the fungus Auxarthron umbrinum. Structure elucidation of new compounds 1 and 2 was accomplished by spectroscopic data analysis while identification of the known pigments (3-5) was achieved by LC-MS-photodiode array detection.
Assuntos
Antraquinonas/química , Antraquinonas/metabolismo , Fungos/metabolismo , Biotecnologia , Fermentação , Proteínas Fúngicas/química , Proteínas Fúngicas/metabolismo , Espectroscopia de Ressonância Magnética , Pigmentos Biológicos/química , Pigmentos Biológicos/metabolismo , Pironas/química , Pironas/metabolismo , Pirróis/química , Pirróis/metabolismoRESUMO
Two new trichothecenes, 14'-hydroxymytoxin B (1) and 16-hydroxyroridin E (3), were isolated from a fermentation extract of Myrothecium roridum. The structures of 1 and 3 were determined by spectral data interpretation. Both compounds showed potent cytotoxic activity against primary soft-tissue sarcoma cells.
Assuntos
Antineoplásicos/isolamento & purificação , Fungos/química , Tricotecenos/isolamento & purificação , Antineoplásicos/química , Antineoplásicos/farmacologia , Boston , Células Cultivadas/efeitos dos fármacos , Cromatografia Líquida de Alta Pressão , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Concentração Inibidora 50 , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Sarcoma , Tricotecenos/química , Tricotecenos/farmacologia , Células Tumorais Cultivadas/efeitos dos fármacosRESUMO
Three novel cytochalasans, phomacins A, B and C, were isolated from a fermentation broth of the fungus Phoma sp. and purified by HSCCC (high speed countercurrent chromatography) followed by HPLC. The structures were determined by 1D and 2D NMR techniques. All three compounds have shown potent inhibitory activity against the HT29 colonic adenocarcinoma cell line.
