Synthesis, Solid State Structure, and Cytotoxic Activity of a Complex Dimer of Yttrium with Anthranilic Acid against Cancer Cells.

This paper presents the synthesis and isolation of a new binuclear complex of yttrium with anthranilic acid (HA). The complex [Y2(HA)6(H2O)4] Cl6.2C2H5OH (C1) was obtained as single crystals that its X-ray analysis revealed its triclinic P-1 space group in addition to anti-prismatic geometry around each of the yttrium ions. In the complex, the anthranilic acid ligands are bidentate, zwitter ionic and neutral, and the yttrium ions' charge is only compensated by six chloride ions. The cytotoxicity of this complex against human breast cancer MDA-MB-231 cells, prostate cancer PC-3 cells, and bladder cancer T-24 cells was evaluated. This yttrium complex displayed more cytotoxic activity against the bladder cancer cells with an IC50 value of 307.7 µg/ml (223 µM). On the other hand, the activities of complex C1 against the MDA-MB-231 and PC-3 cells were less significant respectively with IC50 values of 1097 µg/ml (796 µM) and 921 µg/ml (669 µM).

Synthesis, X-ray structure and anticancer activity evaluation of a binuclear La(III) complex with anthranilic acid.

A binuclear La(III) complex {[La2(HA)4(H2O)4(C2H5OH)2Cl2]Cl4 (C1)} with 2-aminobenzoic acid (HA) was prepared from the ligand and heptahydrated lanthanum chloride. The complex was characterised by X-ray crystallography that revealed anti-prismatic geometry around both of the lanthanum. In the complex, the four 2-aminobenzoic acid ligands are zwitter ionic and the two lanthanum(III) ions net charge is only counterbalanced by chloride ions. The complex cytotoxicity was determined against human breast (MDA-MB-231), prostate (PC-3) and bladder (T-24) cancer cells. This complex afforded cytotoxicity towards the T-24 bladder cancer cells with an IC50 value of 383.5 µg/mL (319 µM). In contrary, activities by the lanthanum complex with IC50 values of 1124 µg/mL (934 µM) and 739 µg/mL (614 µM) were, respectively, shown against the MDA-MB-231 and PC-3 cancer cells. This means the complex is more cytotoxic against the T-24 cells, despite that its activity is less compared with activities shown by classical drugs.

Ultrasound assisted facile synthesis of Mn(II) and Cu(II) coordination polymers and their use as precursors for α-Mn3O4 and CuO nanoparticles: Synthesis, characterization and catalytic properties.

A self-assembly of pyridine-2,6-dicarboxylate with Cu(II) and Mn(II) under ultrasonic and microwave irradiation gave the two coordination polymers [Cu(PDA)(H2O)1.5]n (1) and [Mn(PDA)(H2O)1.5]n (2). Their structures were characterized using IR, elemental analysis, X-ray diffraction (XRD) and spectroscopic methods. The corresponding α-Mn3O4 and CuO nanoparticles were synthesized by calcination of 1 and 2 in air at 600 °C. Transmission electron microscopy (TEM) reveals a sphere-like morphology for the Mn3O4 nanoparticles. Shrinkage of the particle size from 90 nm (by conventional synthesis of the precursor) to 19 nm (ultrasonic-assisted) takes place, indicating the great effect of ultrasonication. CuO nanoparticles were of semispherical (conventional and ultrasonic-assisted methods) and hexagonal shapes (microwave irradiation) with an average diameter of 7, 15 and 25 nm, respectively. The catalytic performance of the coordination polymers towards degradation of methylene blue and methyl orange in the presence of hydrogen peroxide was studied. Using the same dose, catalyst 1 proved to be more efficient in color removal of both MB and MO than catalyst 2 did. Recycling test for 2 showed that it is a recyclable catalyst with no structural changes over three recycling experiments.