Clinicopathological and immunohistochemical analysis of oral melanocytic nevi and review of the literature.

INTRODUCTION: Oral melanocytic nevi (OMNs) are uncommon benign melanocytic tumors, histologically similar to their cutaneous counterparts. The aim of this study was twofold: to contribute to the epidemiology with a literature review with the first Spanish series of OMNs, and to report on clinicopathological, immunohistochemical and demographic findings. MATERIALS AND METHODS: A retrospective analysis of cases attended over the period 1999-2010 was carried out using data drawn from the pathology unit files at two public hospitals in the Spanish region of Andalusia, serving between them a population of 823.614 inhabitants (11%). RESULTS: Ten cases of OMNs were retrieved, accounting for 0.18% of the total 5499 oral biopsies performed over the period. The female-to-male ratio was 1.5:1; mean patient age was 30. The palate was the most common location (70%). Relative frequencies of histologic types were as follows: subepithelial (40%), common blue (30%), compound (20%) and junctional (10%). Immunohistochemical examination showed strong S-100 protein expression, variable reactivity to HMB-45 and high c-Kit expression by junctional melanocytes. Ki-67 was ≤3 in all cases. CONCLUSIONS: Although this first clinicopathologic analysis of OMNs reported in Spain was based on a small patient series, the results are in line with those reported in larger series and additionally provide new demographic data. Since OMNs and early melanomas are usually detected at routine dental examination, detailed oral exploration should always be performed, and in case of doubt a biopsy should be taken to ensure an accurate diagnosis.

Rabdomioma vaginal / Vaginal rhabdomyoma

Se describe un caso de rabdomioma vaginal detectado en una exploración ginecológica rutinaria como tumoración polipoide. El estudio histopatológico después de su exéresis completa mostró las características histológicas e inmunohistoquímicas de la tumoración. Se trata de un tipo de tumor poco frecuente y comportamiento benigno que responde al tratamiento de escisión quirúrgica con márgenes libres. En el seguimiento a los 20 meses no se ha observado recidiva tumoral (AU)

Morphometric study of bone marrow in chronic lymphocytic leukemia.

A morphometric study utilizing the point counting method was carried out on bone marrow biopsies of 44 patients with chronic lymphocytic leukemia (CLL) in order to correlate the objective volume of the lymphocytic infiltration with the histologic patterns (nodular, interstitial, mixed and diffuse) and the clinical stages (A, B and C). The prognostic significance of isolated lymphocytic tumor cell burden was also analyzed. The results suggest that there is a significant correlation between the amount of tumoral lymphoid tissue (VL greater than 60% versus VL less than 60%) and the interstitial and diffuse histologic patterns, as well as with the clinical stages A and C. However, the lymphoid burden did not correlate with the nodular and mixed patterns, nor with the clinical stage B. When patients with VL greater than 60% were compared with those with VL less than 60%, the difference in cumulative survival rates was not significant after the fourth year.

[Pathological anatomy of neoplasms of the pancreas. II. Tumors of the endocrine pancreas]. / Anatomiá patológica de las neoplasias del páncreas. II. Tumores del páncreas endocrino.

The authors make a review of the endocrine pancreas cell and its tumors, describing the main histochemical, immunohistochemical, ultrastructural and clinical features.

[Pathological anatomy of neoplasms of the pancreas. I. Tumors of the exocrine pancreas]. / Anatomía patológica de las neoplasias del páncreas. I. Tumores del páncreas exocrino.

The authors make a review of the exocrine pancreas tumors describing the main clinical, pathological and histogenetic features. The benign neoplasms develop generally from the ductal epithelium and may be cystic or mucinous, the last type suffering some times a malignant transformation. The malignant tumors are very common; histogenetically they may be ductal, acinar or of uncertain origin. Tumor localization, size and invasion are to be taken into consideration for the prognosis.