Breast Cancer in Togolese Women: Imaging and Clinicopathological Findings.

BACKGROUND: Breast cancer is the most common cancer in women, and its incidence and mortality rates are expected to increase significantly over the next few years, particularly in developing countries. The aim of this study was to describe the epidemiological, clinical, radiological, histopathological, and prognostic aspects of breast cancer in Togo. MATERIALS AND METHODS: We retrospectively analyzed at our Department of Pathology of Lomé all cases of breast cancer in women confirmed by histology over a period of 20 years (2000-2019). RESULTS: We collected 804 cases of breast cancer in women. The median age was 46.7 years (range, 12-86 years). Patients aged <40 years represented 48.38% of cases, and the left breast was more affected (51.24%). Most women were sexually active (71.52%) and resided in urban areas (66.29%). Carcinomas represented the predominant histological group (796 cases, 99.00%) with a predominance of invasive nonspecific type carcinoma (92.34%). These cancers were diagnosed at late stage III using Nottingham grading (55.10%). The TNM classification showed a predominance of grades T2NxMx (72.45%) and T4N1Mx (17.76%). The luminal B profile (40.85%) was found mostly, and the mutation of BRCA2 and BRCA1 genes was found in 2.61% of cases. Mastectomy was performed in 7.59%, radiotherapy in 3.61%, and chemotherapy in 18.66%. CONCLUSION: Breast cancer is a frequent pathology in Togolese women, predominant in young adults, often diagnosed at a late stage with limited possibilities of treatment. The establishment of early care programs is essential.

Male Breast Cancer in Togo: Imaging and Clinicopathological Findings.

BACKGROUND: Breast cancer in men is a rare condition, often diagnosed late. The purpose of this study was to describe its epidemiological, histopathological, and radiographic aspects in Togo. MATERIALS AND METHODS: This was a descriptive retrospective study on cases of breast cancer in humans diagnosed histologically at the Laboratory of Anatomy Pathological and Imagery of the University Hospital in Lomé, over a period of 25 years (1995 to 2019). The parameters studied were epidemiological, anatomopathological, and imaging. RESULTS: Eighty-two (82) cases were diagnosed, an annual frequency of 3.28 cases. The mean age was 45 ± 2.5 years; the range was 27-63 years. The family history of 47 patients (57.32%) was known. Carcinomas represented the predominant histological group with predominantly nonspecific invasive carcinoma (87.5%). These cancers were diagnosed at late stages (75.71% grade II). They were mainly of luminal B profile (38.75%) and associated with mutations of the BRCA2 and BRCA1 genes in 14.63% of the cases. The lesions were classified ACR 5 in 61.5% (11/18). Two cases of breast angiosarcoma were diagnosed by the identification of CD31 markers and factor VIII in immunohistochemistry. Hormone therapy such as tamoxifen was prescribed in all luminal patients (43 patients). Radiotherapy was administered to 15 patients (18.3%), with acute toxicity in 20% of the cases. After a median follow-up of 36 months, the evolution was complete remission in 27 patients (32.93%). CONCLUSION: Breast cancer in men is rare, often diagnosed late with a poor prognosis.

Qualité des demandes d'examens radiologiques: à propos de 552 demandes évaluées par des radiologues

Objectifs : Evaluer la qualité des demandes d'examens radiologiques. Matériels et méthodes : Il s'est agi d'une étude transversale descriptive réalisée dans le service de radiologie du CHU Campus du 1er août au 15 août 2015. Résultats : Au cours de la période d'étude, nous avons colligé 144 demandes d'examens de tomodensitométrie (26,1%) et 408 demandes d'examens de radiographie (73,9%). Les demandeurs étaient des médecins spécialistes dans 25% des cas (102 examens) pour la radiographie et 19,4% des cas (28 examens) pour la tomodensitométrie. Les demandeurs d'examen de radiographie étaient des rhumatologues dans 8,8% des cas (36 examens) et aucun urologue n'avait demandé un examen de radiographie ; les demandeurs d'examen de tomodensitométrie étaient des neurologues dans 19,4% des cas (28 examens) et aucun gynécologue ni pédiatre n'avait demandé un examen de tomodensitométrie. Les demandes sans question et les demandes sans retour étaient les deux principaux types de demandes observés. L'âge et le sexe des patients n'avaient pas été précisés respectivement dans 4,4% (18 cas) et 2,9% (12 cas) des demandes d'examen de radiographie. Les résultats d'examens para-cliniques pouvant être utiles à l'interprétation et au compte-rendu radiologique manquaient sur 384 cas (94,1%) des demandes d'examens de radiographie et sur 140 cas (97,2 %) des demandes d'examens de tomodensitométrie. Sur les demandes d'examen de radiographie, le demandeur ne pouvait être identifié par son nom dans 78 cas (19,1%) et le motif de demande était précisé dans 402 cas (98,5 %) ; sur les demandes d'examen de tomodensitométrie, le demandeur ne pouvait être identifié par un numéro de téléphone dans 96 cas (66,7%). Conclusion : Les demandes d'examen radiologiques sont établies de manière incomplète. L'exercice radiologique suppose cependant une obligation de moyens, avec sérieux, prudence et réflexion

Breast cancer cases of female patients under 35 years of age in Togo: A series of 158 cases.

Breast cancer in young female patients represents a public health problem in developing countries. The objectives of the study were to study the epidemiological and histological characteristics of breast cancer in female patients under 35 years of age. This was a retrospective analytical study of a series of 158 cases of breast cancer in female patients under 35 years of age, conducted at the University Teaching Hospital of Lomé between 2000 and 2015. A total of 158 cases were collected, representing 36.2% (436) of all breast cancer cases. The average age of the patients was 30.9 years (range, 16-35 years). A family history of breast cancer at the 1st or 2nd degree was identified in 13.9% of cases. Genetic mutation studies were carried out for 7 patients, 5 of which revealed mutations (4 BRCA1 and 1 BRCA2). According to the locus, the cancer was located preferentially in the left breast in 88 cases (55.7%). Malignant mammary lesions were epithelial tumors (n=144 cases, 91.1%), infiltrating (n=125 cases, 79.1%) and non-infiltrating (n=19 cases, 12.0%). The other histological groups consisted of 8 cases of sarcomas (5 cases of angiosarcoma, 2 cases of fibrosarcoma and 1 case of Kaposi's sarcoma), 5 cases of lymphomas and one case of melanoma. Not otherwise specified infiltrating ductal carcinomas were SBR II and III in 43.2 and 35.2% of cases, respectively. The tumors classified as T4 were the most frequent (30.4%). Regarding the lymph node status, lymph node metastasis was noted in 22.8% of cases. Studies of hormone receptors were carried out in 23 patients and were positive for 11 patients: Estrogen receptor (ER)+plus progesterone receptor (PR)+(7 patients), ER+PR-(4 patients). Of the aforementioned 8 cases of sarcoma, 5 were angiosarcoma. The lymphomas were predominantly Burkitt's type for 4 cases. Mammary ultrasonography was performed in 45.6% of the patients and 54.4% underwent the combined ultrasonography and mammography. Ultrasound identified one or more sign of malignancy in 67 patients (42.4%), and combined ultrasonography and mammography classified 51.9% of lesions in BIRADS 4 and 5. The incidence of breast cancer in young Togolese patients is high. It is a disease distinguished by a delay in diagnosis, which contributes to the high number of cases that initially diagnosed at an advanced stage, particularly the high histo-prognosis grades of infiltrating ductal carcinoma. These results indicate a genetic origin; therefore, a thorough investigation into genetic mutations should be carried. In addition, further collaborative studies are required to verify these results.

Tuberculous Abscess of the Chest Wall Simulate Pyogenic Abscess.

The chest wall tuberculosis abscesses is rare. We present a case of a 27-year-old immunocompetent male who presented chest wall abscesses. Imaging (chest radiographic, ultrasound, and computed tomography) and Ziehl-Neelsen staining demonstrated chest wall tuberculosis abscesses.

Intravenous Contrast Medium Administration for Computed Tomography Scan in Emergency: A Possible Cause of Contrast-Induced Nephropathy.

The goal of this study was to assess risk for CIN after CT Scan during an emergency and to identify risk factors for the patient. Prospective review of all patients admitted to the emergency room (ER) of the Teaching Hospital of Lomé (Togo) during a 2-year period. CIN was defined as an increase in serum creatinine by 0.5 mg/dL from admission after undergoing CT Scan with intravenous contrast. A total of 620 patients underwent a CT Scan in the emergency room using intravenous contrast and 672 patients took the CT Scan without intravenous contrast. Out of the patients who received intravenous contrast for CT Scan, three percent of them developed CIN during their admission. Moreover, upon discharge no patient had continued renal impairment. No patient required dialysis during their admission. The multivariate analysis of all patients who had serial creatinine levels (including those who did not receive any contrast load) shows no increased risk for acute kidney injury associated intravenous contrast (odds ratio = 0.619, p value = 0.886); only diabetes remains independent risk factor of acute kidney injury (odds ratio = 6.26, p value = 0.031).

Aspects tomodensitometriques des demences au Togo

Introduction : La demence est une pathologie en rapport avec l'age dont la prevalence est en progression dans le monde; et en particulier dans les pays en developpement. L'objectif de cette etude etait de determiner les aspects tomodensitometriques des demences au Togo. Patients et Methodes : Il s'agit d'une etude prospective et analytique portant sur 144 patients durant la periode allant de janvier 2011 a decembre 2012. Etaient inclus a l'etude; tout patient presentant une deterioration des fonctions superieures et ayant beneficie d'une tomodensitometrie (TDM) cerebrale. L'examen tomodensitometrique avait ete realise sur un scanner de 16 barrettes de marque General Electric; avec des acquisitions volumiques sans et avec injection du produit de contraste (en cas de necessite) suivies de reconstructions coronales. Resultats : Au total 2320 TDM cerebrales avaient ete realisees pendant la periode d'etude dont 144 pour deterioration des fonctions superieures (6;2). La repartition des patients en fonction de l'age montre une predominance masculine (sex ratio = 1;5). La frequence de la pathologie augmentait avec l'age avec une moyenne de 60 ans. Les causes curables avaient ete retrouvees chez 41 patients (28;5); dominees par l'hydrocephalie chronique de l'adulte. Les causes non curables representaient 78 patients (54;2). La TDM etait normale chez 25 patients (17;3). Conclusion : La tomodensitometrie peut etre suffisante dans l'exploration des demences dans les pays en developpement ou l'acces a l'imagerie par resonnance magnetique est limite

[Aseptic osteonecrosis of the femoral head in children with sickle-cell disease]. / Les ostéonécroses aseptiques de la tête fémorale chez l'enfant drépanocytaire.

PURPOSE: To identify the epidemiological, clinical and therapeutic aspects of hip-joint disorders in children with sickle cell disease, to point out the diagnostic problems, and to stress the necessity of early diagnosis for optimal outcome. MATERIAL AND METHODS: This retrospective study, conducted from January 1987 through December 2006, included children with at least one haemoglobin S gene and hospitalised for osteonecrosis of the femoral head. Ficat staging was used. RESULTS: The study included 14 children (12 boys and 2 girls) with a mean age of 14 years, all hospitalised and treated for osteonecrosis of the femoral head during the study period 8 SS and 6 SC. Osteonecrosis of the femoral head was diagnosed at Ficat stage 3 in 8 cases and at stage 4 in 6. Ten children (8 at stage 3 and 2 at stage 4) had orthopaedic treatment (continuous traction for 30 days and then a Thomas's splint for a mean 14 months). Outcome was good for 6 of the stage-3 cases (mean follow-up period 9 years) and poor for the other patients with purely orthopaedic treatment (mean follow-up period 11 years). Four children at stage 4 underwent surgery (varus osteotomy, immobilization in a cast for 8 weeks, and then Thomas's splint for a mean 12 months) with good results (mean follow-up period 10 years). CONCLUSION: Early diagnosis, assisted by computed tomography, magnetic resonance imaging or scintigraphy, makes it possible to provide better treatment and preserve hip function.