Butyric acid glycerides as substitutes for antibiotics as growth enhancers in the diet of nursery piglets.

This study aimed to determine whether the addition of butyric acid glycerides as substitutes to conventional growth promoters can provide adequate zootechnical performance and intestinal health in healthy piglets in the nursery phase. We used 90 male piglets (average weight of 6.5 kg) subdivided into five treatments with six replicates per treatment. The treatments had the same basal diet: NC-negative control (without growth promoter), PC-positive control (with gentamicin, oral), PSB-protected sodium butyrate, FSB-free sodium butyrate, and TRI-tributyrin. In these animals, zootechnical performance was evaluated on days 1, 10, 20 and 39, microbiological analysis on days 14 and 39, hematocrit, blood biochemistry and intestinal histology, intestinal oxidation and antioxidation on day 39. The average daily weight gain was higher in the TRI group on days 21 to 39 in the nursery (P = 0.03), with more significant weight gain from 1 to 39 days (P = 0.05). There were higher leukocyte counts in the PC group than in the TRI group and higher lymphocyte counts in the PC treatment than in the NC or TRI groups. Escherichia coli counts were lower in the PC, followed by the PSB and TRI groups on day 39 (P = 0.01). Lower crypt depths were found in the TRI and FSB groups, followed by PC, than in the NC group (P = 0.01). Higher values for crypt villosity ratio were found in the FSB and TRI groups than in the NC group (P = 0.05). Lower lipid peroxidation was found in analyzes of serum oxidative status (LPO: P = 0.01), associated with greater activities of superoxide dismutase - SOD (P = 0.08), glutathione S-transferase - GST (P = 0.09) in PSB and TRI groups than in the NC group. In conclusion, the use of butyric acid in the form of tributyrin can be used as growth enhancers in piglets in the nursery phase.

Heterogeneous contributions can jeopardize cooperation in the public goods game.

When studying social dilemma games, a crucial question arises regarding the impact of general heterogeneity on cooperation, which has been shown to have positive effects in numerous studies. Here, we demonstrate that heterogeneity in the contribution value for the focal public goods game can jeopardize cooperation. We show that there is an optimal contribution value in the homogeneous case that most benefits cooperation depending on the lattice. In a heterogeneous scenario, where strategy and contribution coevolve, cooperators making contributions higher than the optimal value end up harming those who contribute less. This effect is notably detrimental to cooperation in the square lattice with von Neumann neighborhood, while it can have no impact in other lattices. Furthermore, in parameter regions where a higher-contributing cooperator cannot normally survive alone, the exploitation of lower-value contribution cooperators allows their survival, resembling a parasitic behavior. To obtain these results, we examined the effect of various distributions for the contribution values in the initial condition and we conducted Monte Carlo simulations.

Moderate immigration may promote a peak of cooperation among natives.

In a world of hardening borders, nations may deprive themselves of enjoying the benefits of cooperative immigrants. Here we analyze the effect of efficient cooperative immigrants on a population playing public goods games. We considered a population structured on a square lattice with individuals playing public goods games with their neighbors. The demographics are determined by stochastic birth, death, and migration. The strategies spread through imitation dynamics. Our model shows that cooperation among natives can emerge due to social contagion of good role-model agents that can provide better quality public goods. Only a small fraction of efficient cooperators, among immigrants, is enough to trigger cooperation across the native population. We see that native cooperation achieves its peak at moderate values of immigration rate. Such efficient immigrant cooperators act as nucleation centers for the growth of cooperative clusters, which eventually dominate defection.

An epidemiological model with voluntary quarantine strategies governed by evolutionary game dynamics.

During pandemic events, strategies such as social distancing can be fundamental to reduce simultaneous infections and mitigate the disease spreading, which is very relevant to the risk of a healthcare system collapse. Although these strategies can be recommended, or even imposed, their actual implementation may depend on the population perception of the risks associated with a potential infection. The current COVID-19 crisis, for instance, is showing that some individuals are much more prone than others to remain isolated. To better understand these dynamics, we propose an epidemiological SIR model that uses evolutionary game theory for combining in a single process social strategies, individual risk perception, and viral spreading. In particular, we consider a disease spreading through a population, whose agents can choose between self-isolation and a lifestyle careless of any epidemic risk. The strategy adoption is individual and depends on the perceived disease risk compared to the quarantine cost. The game payoff governs the strategy adoption, while the epidemic process governs the agent's health state. At the same time, the infection rate depends on the agent's strategy while the perceived disease risk depends on the fraction of infected agents. Our results show recurrent infection waves, which are usually seen in previous historic epidemic scenarios with voluntary quarantine. In particular, such waves re-occur as the population reduces disease awareness. Notably, the risk perception is found to be fundamental for controlling the magnitude of the infection peak, while the final infection size is mainly dictated by the infection rates. Low awareness leads to a single and strong infection peak, while a greater disease risk leads to shorter, although more frequent, peaks. The proposed model spontaneously captures relevant aspects of a pandemic event, highlighting the fundamental role of social strategies.

Symbiotic behaviour in the public goods game with altruistic punishment.

Finding ways to overcome the temptation to exploit one another is still a challenge in behavioural sciences. In the framework of evolutionary game theory, punishing strategies are frequently used to promote cooperation in competitive environments. Here, we introduce altruistic punishers in the spatial public goods game. This strategy acts as a cooperator in the absence of defectors, otherwise it will punish all defectors in their vicinity while bearing a cost to do so. We observe three distinct behaviours in our model: i) in the absence of punishers, cooperators (who don't punish defectors) are driven to extinction by defectors for most parameter values; ii) clusters of punishers thrive by sharing the punishment costs when these are low; iii) for higher punishment costs, punishers, when alone, are subject to exploitation but in the presence of cooperators can form a symbiotic spatial structure that benefits both. This last observation is our main finding since neither cooperation nor punishment alone can survive the defector strategy in this parameter region and the specificity of the symbiotic spatial configuration shows that lattice topology plays a central role in sustaining cooperation. Results were obtained by means of Monte Carlo simulations on a square lattice and subsequently confirmed by a pairwise comparison of different strategies' payoffs in diverse group compositions, leading to a phase diagram of the possible states.

Criticality and Griffiths phases in random games with quenched disorder.

The perceived risk and reward for a given situation can vary depending on resource availability, accumulated wealth, and other extrinsic factors such as individual backgrounds. Based on this general aspect of everyday life, here we use evolutionary game theory to model a scenario with randomly perturbed payoffs in a prisoner's dilemma game. The perception diversity is modeled by adding a zero-average random noise in the payoff entries and a Monte Carlo simulation is used to obtain the population dynamics. This payoff heterogeneity can promote and maintain cooperation in a competitive scenario where only defectors would survive otherwise. In this work, we give a step further, understanding the role of heterogeneity by investigating the effects of quenched disorder in the critical properties of random games. We observe that payoff fluctuations induce a very slow dynamic, making the cooperation decay behave as power laws with varying exponents, instead of the usual exponential decay after the critical point, showing the emergence of a Griffiths phase. We also find a symmetric Griffiths phase near the defector's extinction point when fluctuations are present, indicating that Griffiths phases may be frequent in evolutionary game dynamics and play a role in the coexistence of different strategies.

Strategy equilibrium in dilemma games with off-diagonal payoff perturbations.

We analyze the strategy equilibrium of dilemma games considering a payoff matrix affected by small and random perturbations on the off-diagonal. Notably, a recent work [Proc. R. Soc. A 476, 20200116 (2020)1364-502110.1098/rspa.2020.0116] reported that while cooperation is sustained by perturbations acting on the main diagonal, a less clear scenario emerges when perturbations act on the off-diagonal. Thus, the second case represents the core of this investigation, aimed at completing the description of the effects that payoff perturbations have on the dynamics of evolutionary games. Our results, achieved by analyzing the proposed model under a variety of configurations as different update rules, suggest that off-diagonal perturbations actually constitute a nontrivial form of noise. In particular, the most interesting effects are detected near the phase transition, as perturbations tend to move the strategy distribution towards nonordered states of equilibrium, supporting cooperation when defection is pervading the population, and supporting defection in the opposite case. To conclude, we identified a form of noise that, under controlled conditions, could be used to enhance cooperation and greatly delay its extinction.

Heterogeneity in evolutionary games: an analysis of the risk perception.

In this study, we analyse the relationship between heterogeneity and cooperation. Previous investigations suggest that this relation is non-trivial, as some authors found that heterogeneity sustains cooperation, while others obtained different results. Among the possible forms of heterogeneity, we focus on the individual perception of risks and rewards related to a generic event, which can appear in a number of social and biological systems. The modelling approach is based on the framework of evolutionary game theory. To represent this kind of heterogeneity, we implement small and local perturbations on the pay-off matrix of simple two-strategy games, such as the Prisoner's Dilemma. So, while usually the pay-off is considered to be a global and time-invariant structure, i.e. it is the same for all individuals of a population at any time, in our model its value is continuously affected by small variations, in both time and space (i.e. position on a lattice). We found that such perturbations can be beneficial or detrimental to cooperation, depending on their setting. Notably, cooperation is strongly supported when perturbations act on the main diagonal of the pay-off matrix, whereas when they act on the off-diagonal the resulting effect is more difficult to quantify. To conclude, the proposed model shows a rich spectrum of possible equilibria, whose interpretation might offer insights and enrich the description of several systems.

Role-separating ordering in social dilemmas controlled by topological frustration.

''Three is a crowd" is an old proverb that applies as much to social interactions as it does to frustrated configurations in statistical physics models. Accordingly, social relations within a triangle deserve special attention. With this motivation, we explore the impact of topological frustration on the evolutionary dynamics of the snowdrift game on a triangular lattice. This topology provides an irreconcilable frustration, which prevents anticoordination of competing strategies that would be needed for an optimal outcome of the game. By using different strategy updating protocols, we observe complex spatial patterns in dependence on payoff values that are reminiscent to a honeycomb-like organization, which helps to minimize the negative consequence of the topological frustration. We relate the emergence of these patterns to the microscopic dynamics of the evolutionary process, both by means of mean-field approximations and Monte Carlo simulations. For comparison, we also consider the same evolutionary dynamics on the square lattice, where of course the topological frustration is absent. However, with the deletion of diagonal links of the triangular lattice, we can gradually bridge the gap to the square lattice. Interestingly, in this case the level of cooperation in the system is a direct indicator of the level of topological frustration, thus providing a method to determine frustration levels in an arbitrary interaction network.

Stochastic win-stay-lose-shift strategy with dynamic aspirations in evolutionary social dilemmas.

In times of plenty expectations rise, just as in times of crisis they fall. This can be mathematically described as a win-stay-lose-shift strategy with dynamic aspiration levels, where individuals aspire to be as wealthy as their average neighbor. Here we investigate this model in the realm of evolutionary social dilemmas on the square lattice and scale-free networks. By using the master equation and Monte Carlo simulations, we find that cooperators coexist with defectors in the whole phase diagram, even at high temptations to defect. We study the microscopic mechanism that is responsible for the striking persistence of cooperative behavior and find that cooperation spreads through second-order neighbors, rather than by means of network reciprocity that dominates in imitation-based models. For the square lattice the master equation can be solved analytically in the large temperature limit of the Fermi function, while for other cases the resulting differential equations must be solved numerically. Either way, we find good qualitative agreement with the Monte Carlo simulation results. Our analysis also reveals that the evolutionary outcomes are to a large degree independent of the network topology, including the number of neighbors that are considered for payoff determination on lattices, which further corroborates the local character of the microscopic dynamics. Unlike large-scale spatial patterns that typically emerge due to network reciprocity, here local checkerboard-like patterns remain virtually unaffected by differences in the macroscopic properties of the interaction network.

Evolutionary mixed games in structured populations: Cooperation and the benefits of heterogeneity.

Evolutionary games on networks traditionally involve the same game at each interaction. Here we depart from this assumption by considering mixed games, where the game played at each interaction is drawn uniformly at random from a set of two different games. While in well-mixed populations the random mixture of the two games is always equivalent to the average single game, in structured populations this is not always the case. We show that the outcome is, in fact, strongly dependent on the distance of separation of the two games in the parameter space. Effectively, this distance introduces payoff heterogeneity, and the average game is returned only if the heterogeneity is small. For higher levels of heterogeneity the distance to the average game grows, which often involves the promotion of cooperation. The presented results support preceding research that highlights the favorable role of heterogeneity regardless of its origin, and they also emphasize the importance of the population structure in amplifying facilitators of cooperation.