RESUMO
Quality of life was evaluated in 11 patients with Chagas' disease 26 to 126 months after submission to heart transplantation. There was an objective improvement in their quality of life, after the transplant.
Assuntos
Doença de Chagas/cirurgia , Transplante de Coração , Qualidade de Vida , Adolescente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
BACKGROUND: Eccrine porocarcinoma is an uncommon neoplasm of the intraepidermal sweat gland duct. METHODS: A case of porocarcinoma of the right heel in a male age 51 years is described with a review of pertinent literature. The surgically excised neoplasm was evaluated by routine histology and transmission electron microscopy. RESULTS: The porocarcinoma showed extensive nuclear pleomorphisms with frequent, multinucleated tumor giant cells, focal epidermotrophic spread within the epidermis, a peripheral, eccrine syringofibroadenoma-like growth pattern, and an origin in a contiguous eccrine poroma. Ultrastructurally, the squamous tumor cells contained rare intracytoplasmic lumens. CONCLUSIONS: The extensive nuclear pleomorphism with frequent tumor giant cells was an unusual feature of the porocarcinoma. Its epidermotrophic spread within the epidermis and its origin in a contiguous eccrine poroma supported the diagnosis of porocarcinoma. The eccrine syringofibroadenoma-like growth pattern in the periphery of the tumor was a unique and previously undescribed feature of the porocarcinoma. The presence of intracytoplasmic lumens in squamous tumor cells mimicked embryonic development of the intraepidermal sweat gland duct.
Assuntos
Acrospiroma/patologia , Carcinoma de Células Escamosas/patologia , Calcanhar/patologia , Neoplasias Cutâneas/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Acrospiroma/cirurgia , Biópsia , Carcinoma de Células Escamosas/cirurgia , Divisão Celular/fisiologia , Calcanhar/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Cutâneas/cirurgia , Neoplasias das Glândulas Sudoríparas/cirurgiaAssuntos
Proteínas Sanguíneas/metabolismo , Gota/sangue , Ciclo Menstrual , Progesterona/sangue , Testosterona/sangue , Ácido Úrico/sangue , Adolescente , Adulto , Alopurinol/uso terapêutico , Criança , Pré-Escolar , Feminino , Gota/tratamento farmacológico , Humanos , Masculino , Menopausa , Prolactina/sangue , Ligação Proteica , Valores de Referência , Fatores SexuaisAssuntos
Proteínas Sanguíneas/metabolismo , Estradiol/farmacologia , Progesterona/farmacologia , Testosterona/farmacologia , Ácido Úrico/sangue , Colorimetria , Anticoncepcionais Orais , Ciclofenil/uso terapêutico , Feminino , Humanos , Técnicas In Vitro , Noretindrona/análogos & derivados , Noretindrona/uso terapêutico , Acetato de Noretindrona , Ligação Proteica , Fatores de Tempo , UltrafiltraçãoRESUMO
Modifications on the binding of uric acid to human plasma proteins have been studied in regularly menstruating females aged 25-30 years with a normal cycle, in comparison with a group of healthy age-matched males and with a group of post-menopausal females. The binding of uric acid to plasma proteins was estimated using micropartition system Amicon. The results obtained demonstrate a significant increase of uric acid binding during ovulatory and mid-luteal phase of menstrual cycle. No modifications are shown in post-menopausal females and in healthy males. No modifications have been shown with the same experiments performed in vitro.